pLKO-puro FLAG SREBP1 Citations (14)
Originally described in: mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway.Peterson TR, Sengupta SS, Harris TE, Carmack AE, Kang SA, Balderas E, Guertin DA, Madden KL, Carpenter AE, Finck BN, Sabatini DM Cell. 2011 Aug 5;146(3):408-20. PubMed Journal
Articles Citing pLKO-puro FLAG SREBP1
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| Myostatin induces insulin resistance via Casitas B-lineage lymphoma b (Cblb)-mediated degradation of insulin receptor substrate 1 (IRS1) protein in response to high calorie diet intake. Bonala S, Lokireddy S, McFarlane C, Patnam S, Sharma M, Kambadur R. J Biol Chem. 2014 Mar 14;289(11):7654-70. doi: 10.1074/jbc.M113.529925. Epub 2014 Jan 22. PubMed |
| Single amino acid change in STING leads to constitutive active signaling. Tang ED, Wang CY. PLoS One. 2015 Mar 19;10(3):e0120090. doi: 10.1371/journal.pone.0120090. eCollection 2015. PubMed |
| Genomic deletion of malic enzyme 2 confers collateral lethality in pancreatic cancer. Dey P, Baddour J, Muller F, Wu CC, Wang H, Liao WT, Lan Z, Chen A, Gutschner T, Kang Y, Fleming J, Satani N, Zhao D, Achreja A, Yang L, Lee J, Chang E, Genovese G, Viale A, Ying H, Draetta G, Maitra A, Wang YA, Nagrath D, DePinho RA. Nature. 2017 Feb 2;542(7639):119-123. doi: 10.1038/nature21052. Epub 2017 Jan 18. PubMed |
Skin-specific regulation of SREBP processing and lipid biosynthesis by glycerol kinase 5.
Zhang D, Tomisato W, Su L, Sun L, Choi JH, Zhang Z, Wang KW, Zhan X, Choi M, Li X, Tang M, Castro-Perez JM, Hildebrand S, Murray AR, Moresco EMY, Beutler B.
Proc Natl Acad Sci U S A. 2017 Jun 27;114(26):E5197-E5206. doi: 10.1073/pnas.1705312114. Epub 2017 Jun 12.
PubMed
Associated Plasmids |
| Nutrient sensor O-GlcNAc transferase controls cancer lipid metabolism via SREBP-1 regulation. Sodi VL, Bacigalupa ZA, Ferrer CM, Lee JV, Gocal WA, Mukhopadhyay D, Wellen KE, Ivan M, Reginato MJ. Oncogene. 2018 Feb 15;37(7):924-934. doi: 10.1038/onc.2017.395. Epub 2017 Oct 23. PubMed |
| High glucose induces the apoptosis of HUVECs in mitochondria dependent manner by enhancing VDAC1 expression. Zhang J, Guo Y, Ge W, Zhou X, Pan M. Pharmazie. 2018 Dec 1;73(12):725-728. doi: 10.1691/ph.2018.8544. PubMed |
Extracellular matrix mechanical cues regulate lipid metabolism through Lipin-1 and SREBP.
Romani P, Brian I, Santinon G, Pocaterra A, Audano M, Pedretti S, Mathieu S, Forcato M, Bicciato S, Manneville JB, Mitro N, Dupont S.
Nat Cell Biol. 2019 Mar;21(3):338-347. doi: 10.1038/s41556-018-0270-5. Epub 2019 Feb 4.
PubMed
Associated Plasmids |
| Cholesterol Pathway Inhibition Induces TGF-beta Signaling to Promote Basal Differentiation in Pancreatic Cancer. Gabitova-Cornell L, Surumbayeva A, Peri S, Franco-Barraza J, Restifo D, Weitz N, Ogier C, Goldman AR, Hartman TR, Francescone R, Tan Y, Nicolas E, Shah N, Handorf EA, Cai KQ, O'Reilly AM, Sloma I, Chiaverelli R, Moffitt RA, Khazak V, Fang CY, Golemis EA, Cukierman E, Astsaturov I. Cancer Cell. 2020 Oct 12;38(4):567-583.e11. doi: 10.1016/j.ccell.2020.08.015. Epub 2020 Sep 24. PubMed |
| The fatty acid elongase ELOVL6 regulates bortezomib resistance in multiple myeloma. Lipchick BC, Utley A, Han Z, Moparthy S, Yun DH, Bianchi-Smiraglia A, Wolff DW, Fink E, Liu L, Furdui CM, Lee J, Lee KP, Nikiforov MA. Blood Adv. 2021 Apr 13;5(7):1933-1946. doi: 10.1182/bloodadvances.2020002578. PubMed |
MED1 is a lipogenesis coactivator required for postnatal adipose expansion.
Jang Y, Park YK, Lee JE, Wan D, Tran N, Gavrilova O, Ge K.
Genes Dev. 2021 Apr 22. pii: gad.347583.120. doi: 10.1101/gad.347583.120.
PubMed
Associated Plasmids |
| MUC1-C Dictates JUN and BAF-Mediated Chromatin Remodeling at Enhancer Signatures in Cancer Stem Cells. Bhattacharya A, Fushimi A, Yamashita N, Hagiwara M, Morimoto Y, Rajabi H, Long MD, Abdulla M, Ahmad R, Street K, Liu S, Liu T, Kufe D. Mol Cancer Res. 2022 Apr 1;20(4):556-567. doi: 10.1158/1541-7786.MCR-21-0672. PubMed |
| SREBP1 regulates Lgals3 activation in response to cholesterol loading. Li J, Shen H, Owens GK, Guo LW. Mol Ther Nucleic Acids. 2022 May 18;28:892-909. doi: 10.1016/j.omtn.2022.05.028. eCollection 2022 Jun 14. PubMed |
| The SREBP-dependent regulation of cyclin D1 coordinates cell proliferation and lipid synthesis. Aldaalis A, Bengoechea-Alonso MT, Ericsson J. Front Oncol. 2022 Aug 24;12:942386. doi: 10.3389/fonc.2022.942386. eCollection 2022. PubMed |
| Loss of the Fbw7 tumor suppressor rewires cholesterol metabolism in cancer cells leading to activation of the PI3K-AKT signalling axis. Bengoechea-Alonso MT, Aldaalis A, Ericsson J. Front Oncol. 2022 Sep 13;12:990672. doi: 10.3389/fonc.2022.990672. eCollection 2022. PubMed |
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