pLX304 Citations (121)
Originally described in: A public genome-scale lentiviral expression library of human ORFs.Yang X, Boehm JS, Yang X, Salehi-Ashtiani K, Hao T, Shen Y, Lubonja R, Thomas SR, Alkan O, Bhimdi T, Green TM, Johannessen CM, Silver SJ, Nguyen C, Murray RR, Hieronymus H, Balcha D, Fan C, Lin C, Ghamsari L, Vidal M, Hahn WC, Hill DE, Root DE Nat Methods. 2011 Jun 26;8(8):659-61. doi: 10.1038/nmeth.1638 PubMed Journal
Articles Citing pLX304
| Articles |
|---|
| A melanocyte lineage program confers resistance to MAP kinase pathway inhibition. Johannessen CM, Johnson LA, Piccioni F, Townes A, Frederick DT, Donahue MK, Narayan R, Flaherty KT, Wargo JA, Root DE, Garraway LA. Nature. 2013 Dec 5;504(7478):138-42. doi: 10.1038/nature12688. Epub 2013 Nov 3. PubMed |
| The FOS transcription factor family differentially controls trophoblast migration and invasion. Renaud SJ, Kubota K, Rumi MA, Soares MJ. J Biol Chem. 2014 Feb 21;289(8):5025-39. doi: 10.1074/jbc.M113.523746. Epub 2013 Dec 30. PubMed |
| Reversible and adaptive resistance to BRAF(V600E) inhibition in melanoma. Sun C, Wang L, Huang S, Heynen GJ, Prahallad A, Robert C, Haanen J, Blank C, Wesseling J, Willems SM, Zecchin D, Hobor S, Bajpe PK, Lieftink C, Mateus C, Vagner S, Grernrum W, Hofland I, Schlicker A, Wessels LF, Beijersbergen RL, Bardelli A, Di Nicolantonio F, Eggermont AM, Bernards R. Nature. 2014 Apr 3;508(7494):118-22. doi: 10.1038/nature13121. Epub 2014 Mar 26. PubMed |
| PHLDA1 expression is controlled by an estrogen receptor-NFkappaB-miR-181 regulatory loop and is essential for formation of ER+ mammospheres. Kastrati I, Canestrari E, Frasor J. Oncogene. 2015 Apr 30;34(18):2309-16. doi: 10.1038/onc.2014.180. Epub 2014 Jun 23. PubMed |
| NALP3 inflammasome upregulation and CASP1 cleavage of the glucocorticoid receptor cause glucocorticoid resistance in leukemia cells. Paugh SW, Bonten EJ, Savic D, Ramsey LB, Thierfelder WE, Gurung P, Malireddi RK, Actis M, Mayasundari A, Min J, Coss DR, Laudermilk LT, Panetta JC, McCorkle JR, Fan Y, Crews KR, Stocco G, Wilkinson MR, Ferreira AM, Cheng C, Yang W, Karol SE, Fernandez CA, Diouf B, Smith C, Hicks JK, Zanut A, Giordanengo A, Crona D, Bianchi JJ, Holmfeldt L, Mullighan CG, den Boer ML, Pieters R, Jeha S, Dunwell TL, Latif F, Bhojwani D, Carroll WL, Pui CH, Myers RM, Guy RK, Kanneganti TD, Relling MV, Evans WE. Nat Genet. 2015 Jun;47(6):607-14. doi: 10.1038/ng.3283. Epub 2015 May 4. PubMed |
| Development of novel cellular histone-binding and chromatin-displacement assays for bromodomain drug discovery. Zhan Y, Kost-Alimova M, Shi X, Leo E, Bardenhagen JP, Shepard HE, Appikonda S, Vangamudi B, Zhao S, Tieu TN, Jiang S, Heffernan TP, Marszalek JR, Toniatti C, Draetta G, Tyler J, Barton M, Jones P, Palmer WS, Geck Do MK, Andersen JN. Epigenetics Chromatin. 2015 Sep 21;8:37. doi: 10.1186/s13072-015-0026-4. eCollection 2015. PubMed |
| Poly(A)-specific ribonuclease (PARN) mediates 3'-end maturation of the telomerase RNA component. Moon DH, Segal M, Boyraz B, Guinan E, Hofmann I, Cahan P, Tai AK, Agarwal S. Nat Genet. 2015 Dec;47(12):1482-8. doi: 10.1038/ng.3423. Epub 2015 Oct 19. PubMed |
| Targeting mitochondrial RNA polymerase in acute myeloid leukemia. Bralha FN, Liyanage SU, Hurren R, Wang X, Son MH, Fung TA, Chingcuanco FB, Tung AY, Andreazza AC, Psarianos P, Schimmer AD, Salmena L, Laposa RR. Oncotarget. 2015 Nov 10;6(35):37216-28. doi: 10.18632/oncotarget.6129. PubMed |
| Functional genetic screens for enhancer elements in the human genome using CRISPR-Cas9. Korkmaz G, Lopes R, Ugalde AP, Nevedomskaya E, Han R, Myacheva K, Zwart W, Elkon R, Agami R. Nat Biotechnol. 2016 Feb;34(2):192-8. doi: 10.1038/nbt.3450. Epub 2016 Jan 11. PubMed |
| Microtubules Inhibit E-Cadherin Adhesive Activity by Maintaining Phosphorylated p120-Catenin in a Colon Carcinoma Cell Model. Maiden SL, Petrova YI, Gumbiner BM. PLoS One. 2016 Feb 4;11(2):e0148574. doi: 10.1371/journal.pone.0148574. eCollection 2016. PubMed |
The acetyllysine reader BRD3R promotes human nuclear reprogramming and regulates mitosis.
Shao Z, Zhang R, Khodadadi-Jamayran A, Chen B, Crowley MR, Festok MA, Crossman DK, Townes TM, Hu K.
Nat Commun. 2016 Mar 7;7:10869. doi: 10.1038/ncomms10869.
PubMed
Associated Plasmids |
| Roles for E-cadherin cell surface regulation in cancer. Petrova YI, Schecterson L, Gumbiner BM. Mol Biol Cell. 2016 Nov 1;27(21):3233-3244. Epub 2016 Aug 31. PubMed |
| IKKbeta promotes metabolic adaptation to glutamine deprivation via phosphorylation and inhibition of PFKFB3. Reid MA, Lowman XH, Pan M, Tran TQ, Warmoes MO, Ishak Gabra MB, Yang Y, Locasale JW, Kong M. Genes Dev. 2016 Aug 15;30(16):1837-51. doi: 10.1101/gad.287235.116. Epub 2016 Sep 1. PubMed |
PROTOCADHERIN 7 Acts through SET and PP2A to Potentiate MAPK Signaling by EGFR and KRAS during Lung Tumorigenesis.
Zhou X, Updegraff BL, Guo Y, Peyton M, Girard L, Larsen JE, Xie XJ, Zhou Y, Hwang TH, Xie Y, Rodriguez-Canales J, Villalobos P, Behrens C, Wistuba II, Minna JD, O'Donnell KA.
Cancer Res. 2017 Jan 1;77(1):187-197. doi: 10.1158/0008-5472.CAN-16-1267-T. Epub 2016 Nov 7.
PubMed
Associated Plasmids |
| P21-activated kinase 1 regulates resistance to BRAF inhibition in human cancer cells. Babagana M, Johnson S, Slabodkin H, Bshara W, Morrison C, Kandel ES. Mol Carcinog. 2017 Jan 4. doi: 10.1002/mc.22611. PubMed |
| Highly Expandable Human iPS Cell-Derived Neural Progenitor Cells (NPC) and Neurons for Central Nervous System Disease Modeling and High-Throughput Screening. Cheng C, Fass DM, Folz-Donahue K, MacDonald ME, Haggarty SJ. Curr Protoc Hum Genet. 2017 Jan 11;92:21.8.1-21.8.21. doi: 10.1002/cphg.33. PubMed |
| PARP-1 Controls the Adipogenic Transcriptional Program by PARylating C/EBPbeta and Modulating Its Transcriptional Activity. Luo X, Ryu KW, Kim DS, Nandu T, Medina CJ, Gupte R, Gibson BA, Soccio RE, Yu Y, Gupta RK, Kraus WL. Mol Cell. 2017 Jan 19;65(2):260-271. doi: 10.1016/j.molcel.2016.11.015. PubMed |
| ApoE2, ApoE3, and ApoE4 Differentially Stimulate APP Transcription and Abeta Secretion. Huang YA, Zhou B, Wernig M, Sudhof TC. Cell. 2017 Jan 26;168(3):427-441.e21. doi: 10.1016/j.cell.2016.12.044. Epub 2017 Jan 19. PubMed |
| Creation of Novel Protein Variants with CRISPR/Cas9-Mediated Mutagenesis: Turning a Screening By-Product into a Discovery Tool. Donovan KF, Hegde M, Sullender M, Vaimberg EW, Johannessen CM, Root DE, Doench JG. PLoS One. 2017 Jan 24;12(1):e0170445. doi: 10.1371/journal.pone.0170445. eCollection 2017. PubMed |
| Delete_Profiling Subcellular Protein Phosphatase Responses to Coxsackievirus B3 Infection of Cardiomyocytes. Shah M, Smolko CM, Kinicki S, Chapman ZD, Brautigan DL, Janes KA. Mol Cell Proteomics. 2017 Apr;16(4 suppl 1):S244-S262. doi: 10.1074/mcp.O116.063487. Epub 2017 Feb 7. PubMed |
| SRC-2-mediated coactivation of anti-tumorigenic target genes suppresses MYC-induced liver cancer. Suresh S, Durakoglugil D, Zhou X, Zhu B, Comerford SA, Xing C, Xie XJ, York B, O'Donnell KA. PLoS Genet. 2017 Mar 8;13(3):e1006650. doi: 10.1371/journal.pgen.1006650. eCollection 2017 Mar. PubMed |
| HER2-positive breast cancer cells expressing elevated FAM83A are sensitive to FAM83A loss. Bartel CA, Jackson MW. PLoS One. 2017 May 2;12(5):e0176778. doi: 10.1371/journal.pone.0176778. eCollection 2017. PubMed |
| Exploiting AR-Regulated Drug Transport to Induce Sensitivity to the Survivin Inhibitor YM155. Nyquist MD, Corella A, Burns J, Coleman I, Gao S, Tharakan R, Riggan L, Cai C, Corey E, Nelson PS, Mostaghel EA. Mol Cancer Res. 2017 May;15(5):521-531. doi: 10.1158/1541-7786.MCR-16-0315-T. PubMed |
| Interleukin-like EMT inducer regulates partial phenotype switching in MITF-low melanoma cell lines. Noguchi K, Dalton AC, Howley BV, McCall BJ, Yoshida A, Diehl JA, Howe PH. PLoS One. 2017 May 17;12(5):e0177830. doi: 10.1371/journal.pone.0177830. eCollection 2017. PubMed |
| Systematic and Quantitative Assessment of Hydrogen Peroxide Reactivity With Cysteines Across Human Proteomes. Fu L, Liu K, Sun M, Tian C, Sun R, Morales Betanzos C, Tallman KA, Porter NA, Yang Y, Guo D, Liebler DC, Yang J. Mol Cell Proteomics. 2017 Oct;16(10):1815-1828. doi: 10.1074/mcp.RA117.000108. Epub 2017 Aug 21. PubMed |
| Procyanidin B2 3,3''-di-O-gallate induces oxidative stress-mediated cell death in prostate cancer cells via inhibiting MAP kinase phosphatase activity and activating ERK1/2 and AMPK. Kumar R, Deep G, Wempe MF, Surek J, Kumar A, Agarwal R, Agarwal C. Mol Carcinog. 2018 Jan;57(1):57-69. doi: 10.1002/mc.22731. Epub 2017 Sep 22. PubMed |
| Chromatin accessibility underlies synthetic lethality of SWI/SNF subunits in ARID1A-mutant cancers. Kelso TWR, Porter DK, Amaral ML, Shokhirev MN, Benner C, Hargreaves DC. Elife. 2017 Oct 2;6. pii: 30506. doi: 10.7554/eLife.30506. PubMed |
| Diverse Viruses Require the Calcium Transporter SPCA1 for Maturation and Spread. Hoffmann HH, Schneider WM, Blomen VA, Scull MA, Hovnanian A, Brummelkamp TR, Rice CM. Cell Host Microbe. 2017 Oct 11;22(4):460-470.e5. doi: 10.1016/j.chom.2017.09.002. PubMed |
| Cancer-specific PERK signaling drives invasion and metastasis through CREB3L1. Feng YX, Jin DX, Sokol ES, Reinhardt F, Miller DH, Gupta PB. Nat Commun. 2017 Oct 20;8(1):1079. doi: 10.1038/s41467-017-01052-y. PubMed |
| Interferon regulatory factor 8 regulates caspase-1 expression to facilitate Epstein-Barr virus reactivation in response to B cell receptor stimulation and chemical induction. Lv DW, Zhang K, Li R. PLoS Pathog. 2018 Jan 22;14(1):e1006868. doi: 10.1371/journal.ppat.1006868. eCollection 2018 Jan. PubMed |
| Chaperone-Independent Peripheral Quality Control of CFTR by RFFL E3 Ligase. Okiyoneda T, Veit G, Sakai R, Aki M, Fujihara T, Higashi M, Susuki-Miyata S, Miyata M, Fukuda N, Yoshida A, Xu H, Apaja PM, Lukacs GL. Dev Cell. 2018 Mar 26;44(6):694-708.e7. doi: 10.1016/j.devcel.2018.02.001. Epub 2018 Mar 1. PubMed |
| A multiplatform approach identifies miR-152-3p as a common epigenetically regulated onco-suppressor in prostate cancer targeting TMEM97. Ramalho-Carvalho J, Goncalves CS, Graca I, Bidarra D, Pereira-Silva E, Salta S, Godinho MI, Gomez A, Esteller M, Costa BM, Henrique R, Jeronimo C. Clin Epigenetics. 2018 Mar 27;10:40. doi: 10.1186/s13148-018-0475-2. eCollection 2018. PubMed |
| Cancer Cells Co-opt the Neuronal Redox-Sensing Channel TRPA1 to Promote Oxidative-Stress Tolerance. Takahashi N, Chen HY, Harris IS, Stover DG, Selfors LM, Bronson RT, Deraedt T, Cichowski K, Welm AL, Mori Y, Mills GB, Brugge JS. Cancer Cell. 2018 Jun 11;33(6):985-1003.e7. doi: 10.1016/j.ccell.2018.05.001. Epub 2018 May 24. PubMed |
| Targeting wild-type KRAS-amplified gastroesophageal cancer through combined MEK and SHP2 inhibition. Wong GS, Zhou J, Liu JB, Wu Z, Xu X, Li T, Xu D, Schumacher SE, Puschhof J, McFarland J, Zou C, Dulak A, Henderson L, Xu P, O'Day E, Rendak R, Liao WL, Cecchi F, Hembrough T, Schwartz S, Szeto C, Rustgi AK, Wong KK, Diehl JA, Jensen K, Graziano F, Ruzzo A, Fereshetian S, Mertins P, Carr SA, Beroukhim R, Nakamura K, Oki E, Watanabe M, Baba H, Imamura Y, Catenacci D, Bass AJ. Nat Med. 2018 Jul;24(7):968-977. doi: 10.1038/s41591-018-0022-x. Epub 2018 May 28. PubMed |
| Genome-scale analysis identifies paralog lethality as a vulnerability of chromosome 1p loss in cancer. Viswanathan SR, Nogueira MF, Buss CG, Krill-Burger JM, Wawer MJ, Malolepsza E, Berger AC, Choi PS, Shih J, Taylor AM, Tanenbaum B, Pedamallu CS, Cherniack AD, Tamayo P, Strathdee CA, Lage K, Carr SA, Schenone M, Bhatia SN, Vazquez F, Tsherniak A, Hahn WC, Meyerson M. Nat Genet. 2018 Jul;50(7):937-943. doi: 10.1038/s41588-018-0155-3. Epub 2018 Jun 28. PubMed |
| CUEDC1 is a primary target of ERalpha essential for the growth of breast cancer cells. Lopes R, Korkmaz G, Revilla SA, van Vliet R, Nagel R, Custers L, Kim Y, van Breugel PC, Zwart W, Moumbeini B, Manber Z, Elkon R, Agami R. Cancer Lett. 2018 Nov 1;436:87-95. doi: 10.1016/j.canlet.2018.08.018. Epub 2018 Aug 23. PubMed |
| Emerin Deregulation Links Nuclear Shape Instability to Metastatic Potential. Reis-Sobreiro M, Chen JF, Novitskaya T, You S, Morley S, Steadman K, Gill NK, Eskaros A, Rotinen M, Chu CY, Chung LWK, Tanaka H, Yang W, Knudsen BS, Tseng HR, Rowat AC, Posadas EM, Zijlstra A, Di Vizio D, Freeman MR. Cancer Res. 2018 Nov 1;78(21):6086-6097. doi: 10.1158/0008-5472.CAN-18-0608. Epub 2018 Aug 28. PubMed |
| Differential Splicing of ANP32A in Birds Alters Its Ability to Stimulate RNA Synthesis by Restricted Influenza Polymerase. Baker SF, Ledwith MP, Mehle A. Cell Rep. 2018 Sep 4;24(10):2581-2588.e4. doi: 10.1016/j.celrep.2018.08.012. PubMed |
| The Hippo pathway effector TAZ induces TEAD-dependent liver inflammation and tumors. Hagenbeek TJ, Webster JD, Kljavin NM, Chang MT, Pham T, Lee HJ, Klijn C, Cai AG, Totpal K, Ravishankar B, Yang N, Lee DH, Walsh KB, Hatzivassiliou G, de la Cruz CC, Gould SE, Wu X, Lee WP, Yang S, Zhang Z, Gu Q, Ji Q, Jackson EL, Lim DS, Dey A. Sci Signal. 2018 Sep 11;11(547). pii: 11/547/eaaj1757. doi: 10.1126/scisignal.aaj1757. PubMed |
| Systematic genetic mapping of necroptosis identifies SLC39A7 as modulator of death receptor trafficking. Fauster A, Rebsamen M, Willmann KL, Cesar-Razquin A, Girardi E, Bigenzahn JW, Schischlik F, Scorzoni S, Bruckner M, Konecka J, Hormann K, Heinz LX, Boztug K, Superti-Furga G. Cell Death Differ. 2018 Sep 20. pii: 10.1038/s41418-018-0192-6. doi: 10.1038/s41418-018-0192-6. PubMed |
| Multi-level Proteomics Identifies CT45 as a Chemosensitivity Mediator and Immunotherapy Target in Ovarian Cancer. Coscia F, Lengyel E, Duraiswamy J, Ashcroft B, Bassani-Sternberg M, Wierer M, Johnson A, Wroblewski K, Montag A, Yamada SD, Lopez-Mendez B, Nilsson J, Mund A, Mann M, Curtis M. Cell. 2018 Sep 20;175(1):159-170.e16. doi: 10.1016/j.cell.2018.08.065. PubMed |
| Mannose impairs tumour growth and enhances chemotherapy. Gonzalez PS, O'Prey J, Cardaci S, Barthet VJA, Sakamaki JI, Beaumatin F, Roseweir A, Gay DM, Mackay G, Malviya G, Kania E, Ritchie S, Baudot AD, Zunino B, Mrowinska A, Nixon C, Ennis D, Hoyle A, Millan D, McNeish IA, Sansom OJ, Edwards J, Ryan KM. Nature. 2018 Nov;563(7733):719-723. doi: 10.1038/s41586-018-0729-3. Epub 2018 Nov 21. PubMed |
| The splicing factor RBM25 controls MYC activity in acute myeloid leukemia. Ge Y, Schuster MB, Pundhir S, Rapin N, Bagger FO, Sidiropoulos N, Hashem N, Porse BT. Nat Commun. 2019 Jan 11;10(1):172. doi: 10.1038/s41467-018-08076-y. PubMed |
| The integral function of the endocytic recycling compartment is regulated by RFFL-mediated ubiquitylation of Rab11 effectors. Sakai R, Fukuda R, Unida S, Aki M, Ono Y, Endo A, Kusumi S, Koga D, Fukushima T, Komada M, Okiyoneda T. J Cell Sci. 2019 Feb 7;132(3). pii: jcs.228007. doi: 10.1242/jcs.228007. PubMed |
| L1 drives IFN in senescent cells and promotes age-associated inflammation. De Cecco M, Ito T, Petrashen AP, Elias AE, Skvir NJ, Criscione SW, Caligiana A, Brocculi G, Adney EM, Boeke JD, Le O, Beausejour C, Ambati J, Ambati K, Simon M, Seluanov A, Gorbunova V, Slagboom PE, Helfand SL, Neretti N, Sedivy JM. Nature. 2019 Feb;566(7742):73-78. doi: 10.1038/s41586-018-0784-9. Epub 2019 Feb 6. PubMed |
| miR-101 suppresses the development of MLL-rearranged acute myeloid leukemia. Gonzales-Aloy E, Connerty P, Salik B, Liu B, Woo AJ, Haber M, Norris MD, Wang J, Wang JY. Haematologica. 2019 Jul;104(7):e296-e299. doi: 10.3324/haematol.2018.209437. Epub 2019 Feb 21. PubMed |
| CHD4 regulates the DNA damage response and RAD51 expression in glioblastoma. McKenzie LD, LeClair JW, Miller KN, Strong AD, Chan HL, Oates EL, Ligon KL, Brennan CW, Chheda MG. Sci Rep. 2019 Mar 14;9(1):4444. doi: 10.1038/s41598-019-40327-w. PubMed |
| Comprehensive profiling of the STE20 kinase family defines features essential for selective substrate targeting and signaling output. Miller CJ, Lou HJ, Simpson C, van de Kooij B, Ha BH, Fisher OS, Pirman NL, Boggon TJ, Rinehart J, Yaffe MB, Linding R, Turk BE. PLoS Biol. 2019 Mar 21;17(3):e2006540. doi: 10.1371/journal.pbio.2006540. eCollection 2019 Mar. PubMed |
| Prohibitin promotes de-differentiation and is a potential therapeutic target in neuroblastoma. MacArthur IC, Bei Y, Garcia HD, Ortiz MV, Toedling J, Klironomos F, Rolff J, Eggert A, Schulte JH, Kentsis A, Henssen AG. JCI Insight. 2019 Apr 18;5. pii: 127130. doi: 10.1172/jci.insight.127130. PubMed |
| EWSR1-FLI1 Activation of the Cancer/Testis Antigen FATE1 Promotes Ewing Sarcoma Survival. Gallegos ZR, Taus P, Gibbs ZA, McGlynn K, Gomez NC, Davis I, Whitehurst AW. Mol Cell Biol. 2019 Jun 27;39(14). pii: MCB.00138-19. doi: 10.1128/MCB.00138-19. Print 2019 Jul 15. PubMed |
| Genomic and Transcriptomic Determinants of Therapy Resistance and Immune Landscape Evolution during Anti-EGFR Treatment in Colorectal Cancer. Woolston A, Khan K, Spain G, Barber LJ, Griffiths B, Gonzalez-Exposito R, Hornsteiner L, Punta M, Patil Y, Newey A, Mansukhani S, Davies MN, Furness A, Sclafani F, Peckitt C, Jimenez M, Kouvelakis K, Ranftl R, Begum R, Rana I, Thomas J, Bryant A, Quezada S, Wotherspoon A, Khan N, Fotiadis N, Marafioti T, Powles T, Lise S, Calvo F, Guettler S, von Loga K, Rao S, Watkins D, Starling N, Chau I, Sadanandam A, Cunningham D, Gerlinger M. Cancer Cell. 2019 Jul 8;36(1):35-50.e9. doi: 10.1016/j.ccell.2019.05.013. PubMed |
| Conserved Herpesvirus Protein Kinases Target SAMHD1 to Facilitate Virus Replication. Zhang K, Lv DW, Li R. Cell Rep. 2019 Jul 9;28(2):449-459.e5. doi: 10.1016/j.celrep.2019.04.020. PubMed |
| Syndecan-4 regulates extravillous trophoblast migration by coordinating protein kinase C activation. Jeyarajah MJ, Jaju Bhattad G, Kops BF, Renaud SJ. Sci Rep. 2019 Jul 15;9(1):10175. doi: 10.1038/s41598-019-46599-6. PubMed |
| The transporters SLC35A1 and SLC30A1 play opposite roles in cell survival upon VSV virus infection. Moskovskich A, Goldmann U, Kartnig F, Lindinger S, Konecka J, Fiume G, Girardi E, Superti-Furga G. Sci Rep. 2019 Jul 18;9(1):10471. doi: 10.1038/s41598-019-46952-9. PubMed |
| Differential Signaling Mediated by ApoE2, ApoE3, and ApoE4 in Human Neurons Parallels Alzheimer's Disease Risk. Huang YA, Zhou B, Nabet AM, Wernig M, Sudhof TC. J Neurosci. 2019 Sep 11;39(37):7408-7427. doi: 10.1523/JNEUROSCI.2994-18.2019. Epub 2019 Jul 22. PubMed |
| A CRISPR Screen Identifies the Cell Polarity Determinant Crumbs 3 as an Adeno-associated Virus Restriction Factor in Hepatocytes. Madigan VJ, Tyson TO, Yuziuk JA, Pillai M, Moller-Tank S, Asokan A. J Virol. 2019 Oct 15;93(21). pii: JVI.00943-19. doi: 10.1128/JVI.00943-19. Print 2019 Nov 1. PubMed |
Dualism of FGF and TGF-beta Signaling in Heterogeneous Cancer-Associated Fibroblast Activation with ETV1 as a Critical Determinant.
Bordignon P, Bottoni G, Xu X, Popescu AS, Truan Z, Guenova E, Kofler L, Jafari P, Ostano P, Rocken M, Neel V, Dotto GP.
Cell Rep. 2019 Aug 27;28(9):2358-2372.e6. doi: 10.1016/j.celrep.2019.07.092.
PubMed
Associated Plasmids |
| The Hippo Pathway Effector TAZ Regulates Ferroptosis in Renal Cell Carcinoma. Yang WH, Ding CC, Sun T, Rupprecht G, Lin CC, Hsu D, Chi JT. Cell Rep. 2019 Sep 3;28(10):2501-2508.e4. doi: 10.1016/j.celrep.2019.07.107. PubMed |
| SMARCD1 is a transcriptional target of specific non-hotspot mutant p53 forms. Adduri RSR, George SA, Kavadipula P, Bashyam MD. J Cell Physiol. 2020 May;235(5):4559-4570. doi: 10.1002/jcp.29332. Epub 2019 Oct 21. PubMed |
| DUSP10 Is a Regulator of YAP1 Activity Promoting Cell Proliferation and Colorectal Cancer Progression. Jimenez-Martinez M, Ostale CM, van der Burg LR, Galan-Martinez J, Hardwick JCH, Lopez-Perez R, Hawinkels LJAC, Stamatakis K, Fresno M. Cancers (Basel). 2019 Nov 9;11(11). pii: cancers11111767. doi: 10.3390/cancers11111767. PubMed |
| EPS8 Facilitates Uncoating of Influenza A Virus. Larson GP, Tran V, Yu S, Cai Y, Higgins CA, Smith DM, Baker SF, Radoshitzky SR, Kuhn JH, Mehle A. Cell Rep. 2019 Nov 19;29(8):2175-2183.e4. doi: 10.1016/j.celrep.2019.10.064. PubMed |
| Low-Level Saturated Fatty Acid Palmitate Benefits Liver Cells by Boosting Mitochondrial Metabolism via CDK1-SIRT3-CPT2 Cascade. Liu L, Xie B, Fan M, Candas-Green D, Jiang JX, Wei R, Wang Y, Chen HW, Hu Y, Li JJ. Dev Cell. 2020 Jan 27;52(2):196-209.e9. doi: 10.1016/j.devcel.2019.11.012. Epub 2019 Dec 19. PubMed |
| Protein arginine methyltransferase 5 promotes cholesterol biosynthesis-mediated Th17 responses and autoimmunity. Webb LM, Sengupta S, Edell C, Piedra-Quintero ZL, Amici SA, Miranda JN, Bevins M, Kennemer A, Laliotis G, Tsichlis PN, Guerau-de-Arellano M. J Clin Invest. 2020 Apr 1;130(4):1683-1698. doi: 10.1172/JCI131254. PubMed |
A widespread role for SLC transmembrane transporters in resistance to cytotoxic drugs.
Girardi E, Cesar-Razquin A, Lindinger S, Papakostas K, Konecka J, Hemmerich J, Kickinger S, Kartnig F, Gurtl B, Klavins K, Sedlyarov V, Ingles-Prieto A, Fiume G, Koren A, Lardeau CH, Kumaran Kandasamy R, Kubicek S, Ecker GF, Superti-Furga G.
Nat Chem Biol. 2020 Apr;16(4):469-478. doi: 10.1038/s41589-020-0483-3. Epub 2020 Mar 9.
PubMed
Associated Plasmids |
| Targeting Hippo-Dependent and Hippo-Independent YAP1 Signaling for the Treatment of Childhood Rhabdomyosarcoma. Slemmons KK, Yeung C, Baumgart JT, Juarez JOM, McCalla A, Helman LJ. Cancer Res. 2020 Jul 15;80(14):3046-3056. doi: 10.1158/0008-5472.CAN-19-3853. Epub 2020 Apr 30. PubMed |
| Laminin-511 and alpha6 integrins regulate the expression of CXCR4 to promote endothelial morphogenesis. Xu H, Pumiglia K, LaFlamme SE. J Cell Sci. 2020 Jun 11;133(11). pii: jcs.246595. doi: 10.1242/jcs.246595. PubMed |
| SHP2 inhibition diminishes KRASG12C cycling and promotes tumor microenvironment remodeling. Fedele C, Li S, Teng KW, Foster CJR, Peng D, Ran H, Mita P, Geer MJ, Hattori T, Koide A, Wang Y, Tang KH, Leinwand J, Wang W, Diskin B, Deng J, Chen T, Dolgalev I, Ozerdem U, Miller G, Koide S, Wong KK, Neel BG. J Exp Med. 2021 Jan 4;218(1). pii: 211451. doi: 10.1084/jem.20201414. PubMed |
| SHOC2 Is a Critical Modulator of Sensitivity to EGFR-TKIs in Non-Small Cell Lung Cancer Cells. Terai H, Hamamoto J, Emoto K, Masuda T, Manabe T, Kuronuma S, Kobayashi K, Masuzawa K, Ikemura S, Nakayama S, Kawada I, Suzuki Y, Takeuchi O, Suzuki Y, Ohtsuki S, Yasuda H, Soejima K, Fukunaga K. Mol Cancer Res. 2021 Feb;19(2):317-328. doi: 10.1158/1541-7786.MCR-20-0664. Epub 2020 Oct 26. PubMed |
| TMEM41B Is a Pan-flavivirus Host Factor. Hoffmann HH, Schneider WM, Rozen-Gagnon K, Miles LA, Schuster F, Razooky B, Jacobson E, Wu X, Yi S, Rudin CM, MacDonald MR, McMullan LK, Poirier JT, Rice CM. Cell. 2021 Jan 7;184(1):133-148.e20. doi: 10.1016/j.cell.2020.12.005. Epub 2020 Dec 9. PubMed |
| NAD(+) boosting reduces age-associated amyloidosis and restores mitochondrial homeostasis in muscle. Romani M, Sorrentino V, Oh CM, Li H, de Lima TI, Zhang H, Shong M, Auwerx J. Cell Rep. 2021 Jan 19;34(3):108660. doi: 10.1016/j.celrep.2020.108660. PubMed |
| Modulating HSF1 levels impacts expression of the estrogen receptor alpha and antiestrogen response. Silveira MA, Tav C, Berube-Simard FA, Cuppens T, Leclercq M, Fournier E, Cote MC, Droit A, Bilodeau S. Life Sci Alliance. 2021 Feb 16;4(5). pii: 4/5/e202000811. doi: 10.26508/lsa.202000811. Print 2021 May. PubMed |
| Distinct genetic pathways define pre-malignant versus compensatory clonal hematopoiesis in Shwachman-Diamond syndrome. Kennedy AL, Myers KC, Bowman J, Gibson CJ, Camarda ND, Furutani E, Muscato GM, Klein RH, Ballotti K, Liu S, Harris CE, Galvin A, Malsch M, Dale D, Gansner JM, Nakano TA, Bertuch A, Vlachos A, Lipton JM, Castillo P, Connelly J, Churpek J, Edwards JR, Hijiya N, Ho RH, Hofmann I, Huang JN, Keel S, Lamble A, Lau BW, Norkin M, Stieglitz E, Stock W, Walkovich K, Boettcher S, Brendel C, Fleming MD, Davies SM, Weller EA, Bahl C, Carter SL, Shimamura A, Lindsley RC. Nat Commun. 2021 Feb 26;12(1):1334. doi: 10.1038/s41467-021-21588-4. PubMed |
| Peroxisomal-derived ether phospholipids link nucleotides to respirasome assembly. Bennett CF, O'Malley KE, Perry EA, Balsa E, Latorre-Muro P, Riley CL, Luo C, Jedrychowski M, Gygi SP, Puigserver P. Nat Chem Biol. 2021 Jun;17(6):703-710. doi: 10.1038/s41589-021-00772-z. Epub 2021 Mar 15. PubMed |
| The tumor suppressor kinase DAPK3 drives tumor-intrinsic immunity through the STING-IFN-beta pathway. Takahashi M, Lio CJ, Campeau A, Steger M, Ay F, Mann M, Gonzalez DJ, Jain M, Sharma S. Nat Immunol. 2021 Apr;22(4):485-496. doi: 10.1038/s41590-021-00896-3. Epub 2021 Mar 25. PubMed |
| Squamous cell carcinoma subverts adjacent histologically normal epithelium to promote lateral invasion. Singh P, Banerjee R, Piao S, Costa de Medeiros M, Bellile E, Liu M, Damodaran Puthiya Veettil D, Schmitd LB, Russo N, Danella E, Inglehart RC, Pineault KM, Wellik DM, Wolf G, D'Silva NJ. J Exp Med. 2021 Jun 7;218(6). pii: 211968. doi: 10.1084/jem.20200944. PubMed |
| Ferroptotic cell death triggered by conjugated linolenic acids is mediated by ACSL1. Beatty A, Singh T, Tyurina YY, Tyurin VA, Samovich S, Nicolas E, Maslar K, Zhou Y, Cai KQ, Tan Y, Doll S, Conrad M, Subramanian A, Bayir H, Kagan VE, Rennefahrt U, Peterson JR. Nat Commun. 2021 Apr 14;12(1):2244. doi: 10.1038/s41467-021-22471-y. PubMed |
| Pathways and signatures of mutagenesis at targeted DNA nicks. Zhang Y, Davis L, Maizels N. PLoS Genet. 2021 Apr 15;17(4):e1009329. doi: 10.1371/journal.pgen.1009329. eCollection 2021 Apr. PubMed |
| Unrestrained poly-ADP-ribosylation provides insights into chromatin regulation and human disease. Prokhorova E, Agnew T, Wondisford AR, Tellier M, Kaminski N, Beijer D, Holder J, Groslambert J, Suskiewicz MJ, Zhu K, Reber JM, Krassnig SC, Palazzo L, Murphy S, Nielsen ML, Mangerich A, Ahel D, Baets J, O'Sullivan RJ, Ahel I. Mol Cell. 2021 Jun 17;81(12):2640-2655.e8. doi: 10.1016/j.molcel.2021.04.028. Epub 2021 May 20. PubMed |
| NORAD-induced Pumilio phase separation is required for genome stability. Elguindy MM, Mendell JT. Nature. 2021 Jul;595(7866):303-308. doi: 10.1038/s41586-021-03633-w. Epub 2021 Jun 9. PubMed |
| AKT3-mediated IWS1 phosphorylation promotes the proliferation of EGFR-mutant lung adenocarcinomas through cell cycle-regulated U2AF2 RNA splicing. Laliotis GI, Chavdoula E, Paraskevopoulou MD, Kaba A, La Ferlita A, Singh S, Anastas V, Nair KA 2nd, Orlacchio A, Taraslia V, Vlachos I, Capece M, Hatzigeorgiou A, Palmieri D, Tsatsanis C, Alaimo S, Sehgal L, Carbone DP, Coppola V, Tsichlis PN. Nat Commun. 2021 Jul 30;12(1):4624. doi: 10.1038/s41467-021-24795-1. PubMed |
| Electrophysiological engineering of heart-derived cells with calcium-dependent potassium channels improves cell therapy efficacy for cardioprotection. Vigneault P, Parent S, Kanda P, Michie C, Davis DR, Nattel S. Nat Commun. 2021 Aug 16;12(1):4963. doi: 10.1038/s41467-021-25180-8. PubMed |
| Epigenetic Regulation of Fanconi Anemia Genes Implicates PRMT5 Blockage as a Strategy for Tumor Chemosensitization. Du C, Li SW, Singh SX, Roso K, Sun MA, Pirozzi CJ, Yang R, Li JL, He Y. Mol Cancer Res. 2021 Dec;19(12):2046-2056. doi: 10.1158/1541-7786.MCR-21-0093. Epub 2021 Sep 14. PubMed |
| Disruption of pancreatic stellate cell myofibroblast phenotype promotes pancreatic tumor invasion. Murray ER, Menezes S, Henry JC, Williams JL, Alba-Castellon L, Baskaran P, Quetier I, Desai A, Marshall JJT, Rosewell I, Tatari M, Rajeeve V, Khan F, Wang J, Kotantaki P, Tyler EJ, Singh N, Reader CS, Carter EP, Hodivala-Dilke K, Grose RP, Kocher HM, Gavara N, Pearce O, Cutillas P, Marshall JF, Cameron AJM. Cell Rep. 2022 Jan 25;38(4):110227. doi: 10.1016/j.celrep.2021.110227. PubMed |
| Tousled-like kinase 2 targets ASF1 histone chaperones through client mimicry. Simon B, Lou HJ, Huet-Calderwood C, Shi G, Boggon TJ, Turk BE, Calderwood DA. Nat Commun. 2022 Feb 8;13(1):749. doi: 10.1038/s41467-022-28427-0. PubMed |
| The Ubiquitin Ligase RNF34 Participates in the Peripheral Quality Control of CFTR (RNF34 Role in CFTR PeriQC). Taniguchi S, Ito Y, Kiritani H, Maruo A, Sakai R, Ono Y, Fukuda R, Okiyoneda T. Front Mol Biosci. 2022 Mar 9;9:840649. doi: 10.3389/fmolb.2022.840649. eCollection 2022. PubMed |
| The AMPK-related kinase NUAK2 suppresses glutathione peroxidase 4 expression and promotes ferroptotic cell death in breast cancer cells. Singh T, Beatty A, Peterson JR. Cell Death Discov. 2022 May 6;8(1):253. doi: 10.1038/s41420-022-01044-y. PubMed |
| Liver ductal organoids reconstruct intrahepatic biliary trees in decellularized liver grafts. Tomofuji K, Fukumitsu K, Kondo J, Horie H, Makino K, Wakama S, Ito T, Oshima Y, Ogiso S, Ishii T, Inoue M, Hatano E. Biomaterials. 2022 Jun 1;287:121614. doi: 10.1016/j.biomaterials.2022.121614. PubMed |
| Supramolecular assembly of GSK3alpha as a cellular response to amino acid starvation. Hinze L, Schreek S, Zeug A, Ibrahim NK, Fehlhaber B, Loxha L, Cinar B, Ponimaskin E, Degar J, McGuckin C, Chiosis G, Eckert C, Cario G, Bornhauser B, Bourquin JP, Stanulla M, Gutierrez A. Mol Cell. 2022 Aug 4;82(15):2858-2870.e8. doi: 10.1016/j.molcel.2022.05.025. Epub 2022 Jun 21. PubMed |
| Integrated regulation of stress responses, autophagy and survival by altered intracellular iron stores. Wang Y, Wang M, Liu Y, Tao H, Banerjee S, Srinivasan S, Nemeth E, Czaja MJ, He P. Redox Biol. 2022 Jul 14;55:102407. doi: 10.1016/j.redox.2022.102407. PubMed |
| TGFBR3 supports anoikis through suppressing ATF4 signaling. Hsu YJ, Yin YJ, Tsai KF, Jian CC, Liang ZW, Hsu CY, Wang CC. J Cell Sci. 2022 Sep 1;135(17):jcs258396. doi: 10.1242/jcs.258396. Epub 2022 Aug 30. PubMed |
| Alternative splicing liberates a cryptic cytoplasmic isoform of mitochondrial MECR that antagonizes influenza virus. Baker SF, Meistermann H, Tzouros M, Baker A, Golling S, Polster JS, Ledwith MP, Gitter A, Augustin A, Javanbakht H, Mehle A. PLoS Biol. 2022 Dec 21;20(12):e3001934. doi: 10.1371/journal.pbio.3001934. eCollection 2022 Dec. PubMed |
| Mitochondrial redox adaptations enable alternative aspartate synthesis in SDH-deficient cells. Hart ML, Quon E, Vigil ABG, Engstrom IA, Newsom OJ, Davidsen K, Hoellerbauer P, Carlisle SM, Sullivan LB. Elife. 2023 Mar 8;12:e78654. doi: 10.7554/eLife.78654. PubMed |
| VCP/p97, a pleiotropic protein regulator of the DNA damage response and proteostasis, is a potential therapeutic target in KRAS-mutant pancreatic cancer. Lee YS, Klomp JE, Stalnecker CA, Goodwin CM, Gao Y, Droby GN, Vaziri C, Bryant KL, Der CJ, Cox AD. Genes Cancer. 2023 Mar 10;14:30-49. doi: 10.18632/genesandcancer.231. eCollection 2023. PubMed |
| Lysyl oxidase regulates epithelial differentiation and barrier integrity in eosinophilic esophagitis. Sasaki M, Hara T, Wang JX, Zhou Y, Kennedy KV, Umeweni NN, Alston MA, Spergel ZC, Nakagawa R, Mcmillan EA, Whelan KA, Karakasheva TA, Hamilton KE, Ruffner MA, Muir AB. bioRxiv. 2023 Mar 28:2023.03.27.534387. doi: 10.1101/2023.03.27.534387. Preprint. PubMed |
| Hepatocyte differentiation from mouse liver ductal organoids by transducing 4 liver-specific transcription factors. Tomofuji K, Kondo J, Onuma K, Coppo R, Horie H, Oyama K, Miyoshi E, Fukumitsu K, Ishii T, Hatano E, Inoue M. Hepatol Commun. 2023 Apr 14;7(5):e0134. doi: 10.1097/HC9.0000000000000134. eCollection 2023 May 1. PubMed |
| Enveloped viruses pseudotyped with mammalian myogenic cell fusogens target skeletal muscle for gene delivery. Hindi SM, Petrany MJ, Greenfeld E, Focke LC, Cramer AAW, Whitt MA, Khairallah RJ, Ward CW, Chamberlain JS, Podbilewicz B, Prasad V, Millay DP. Cell. 2023 May 11;186(10):2062-2077.e17. doi: 10.1016/j.cell.2023.03.033. Epub 2023 Apr 18. PubMed |
| Vangl-dependent Wnt/planar cell polarity signaling mediates collective breast carcinoma motility and distant metastasis. VanderVorst K, Dreyer CA, Hatakeyama J, Bell GRR, Learn JA, Berg AL, Hernandez M, Lee H, Collins SR, Carraway KL 3rd. Breast Cancer Res. 2023 May 5;25(1):52. doi: 10.1186/s13058-023-01651-2. PubMed |
| SELENOP modifies sporadic colorectal carcinogenesis and WNT signaling activity through LRP5/6 interactions. Pilat JM, Brown RE, Chen Z, Berle NJ, Othon AP, Washington MK, Anant SA, Kurokawa S, Ng VH, Thompson JJ, Jacobse J, Goettel JA, Lee E, Choksi YA, Lau KS, Short SP, Williams CS. J Clin Invest. 2023 Jul 3;133(13):e165988. doi: 10.1172/JCI165988. PubMed |
| Patient Specific Targeting of the T-cell Receptor Variable Region as a Therapeutic Strategy in Clonal T-Cell Diseases. Lucero OM, Lee JA, Bowman J, Johnson K, Sapparapu G, Thomas JK, Fan G, Chang BH, Thiel-Klare K, Eide CA, Okada C, Palazzolo M, Lind E, Kosaka Y, Druker BJ, Lydon N, Bowers PM. Clin Cancer Res. 2023 May 18:CCR-22-0906. doi: 10.1158/1078-0432.CCR-22-0906. PubMed |
| Intracellular pH dynamics regulates intestinal stem cell lineage specification. Liu Y, Reyes E, Castillo-Azofeifa D, Klein OD, Nystul T, Barber DL. Nat Commun. 2023 Jun 23;14(1):3745. doi: 10.1038/s41467-023-39312-9. PubMed |
| Regulation of LRRK2 mRNA stability by ATIC and its substrate AICAR through ARE-mediated mRNA decay in Parkinson's disease. Liu Q, Zhu D, Li N, Chen S, Hu L, Yu J, Xiong Y. EMBO J. 2023 Aug 1;42(15):e113410. doi: 10.15252/embj.2022113410. Epub 2023 Jun 27. PubMed |
| Melanoma-intrinsic NR2F6 activity regulates antitumor immunity. Kim H, Feng Y, Murad R, Pozniak J, Pelz C, Chen Y, Dalal B, Sears R, Sergienko E, Jackson M, Ruppin E, Herlyn M, Harris C, Marine JC, Klepsch V, Baier G, Ronai ZA. Sci Adv. 2023 Jul 7;9(27):eadf6621. doi: 10.1126/sciadv.adf6621. Epub 2023 Jul 5. PubMed |
| Role of Nudt2 in Anchorage-Independent Growth and Cell Migration of Human Melanoma. Hidmi S, Nechushtan H, Razin E, Tshori S. Int J Mol Sci. 2023 Jun 22;24(13):10513. doi: 10.3390/ijms241310513. PubMed |
| Genome-wide CRISPR screens define determinants of epithelial-mesenchymal transition mediated immune evasion by pancreatic cancer cells. Gu Y, Zhang Z, Camps MGM, Ossendorp F, Wijdeven RH, Ten Dijke P. Sci Adv. 2023 Jul 14;9(28):eadf9915. doi: 10.1126/sciadv.adf9915. Epub 2023 Jul 14. PubMed |
| Inhibition of Abelson Tyrosine-Protein Kinase 2 Suppresses the Development of Alcohol-Associated Liver Disease by Decreasing PPARgamma Expression. Malnassy G, Keating CR, Gad S, Bridgeman B, Perera A, Hou W, Cotler SJ, Ding X, Choudhry M, Sun Z, Koleske AJ, Qiu W. Cell Mol Gastroenterol Hepatol. 2023;16(5):685-709. doi: 10.1016/j.jcmgh.2023.07.006. Epub 2023 Jul 15. PubMed |
| TIGIT can inhibit T cell activation via ligation-induced nanoclusters, independent of CD226 co-stimulation. Worboys JD, Vowell KN, Hare RK, Ambrose AR, Bertuzzi M, Conner MA, Patel FP, Zammit WH, Gali-Moya J, Hazime KS, Jones KL, Rey C, Jonjic S, Rovis TL, Tannahill GM, Cruz De Matos GDS, Waight JD, Davis DM. Nat Commun. 2023 Aug 18;14(1):5016. doi: 10.1038/s41467-023-40755-3. PubMed |
| Genome-Wide CRISPR Screens Identify Multiple Synthetic Lethal Targets That Enhance KRASG12C Inhibitor Efficacy. Mukhopadhyay S, Huang HY, Lin Z, Ranieri M, Li S, Sahu S, Liu Y, Ban Y, Guidry K, Hu H, Lopez A, Sherman F, Tan YJ, Lee YT, Armstrong AP, Dolgalev I, Sahu P, Zhang T, Lu W, Gray NS, Christensen JG, Tang TT, Velcheti V, Khodadadi-Jamayran A, Wong KK, Neel BG. Cancer Res. 2023 Dec 15;83(24):4095-4111. doi: 10.1158/0008-5472.CAN-23-2729. PubMed |
| Multidimensional quantitative phenotypic and molecular analysis reveals neomorphic behaviors of p53 missense mutants. Pal A, Gonzalez-Malerva L, Eaton S, Xu C, Zhang Y, Grief D, Sakala L, Nwekwo L, Zeng J, Christensen G, Gupta C, Streitwieser E, Singharoy A, Park JG, LaBaer J. NPJ Breast Cancer. 2023 Sep 29;9(1):78. doi: 10.1038/s41523-023-00582-7. PubMed |
| HOXC6 drives a therapeutically targetable pancreatic cancer growth and metastasis pathway by regulating MSK1 and PPP2R2B. Malvi P, Chava S, Cai G, Hu K, Zhu LJ, Edwards YJK, Green MR, Gupta R, Wajapeyee N. Cell Rep Med. 2023 Nov 21;4(11):101285. doi: 10.1016/j.xcrm.2023.101285. Epub 2023 Nov 10. PubMed |
| Adipose Triglyceride Lipase Is a Therapeutic Target in Advanced Prostate Cancer That Promotes Metabolic Plasticity. Awad D, Cao PHA, Pulliam TL, Spradlin M, Subramani E, Tellman TV, Ribeiro CF, Muzzioli R, Jewell BE, Pakula H, Ackroyd JJ, Murray MM, Han JJ, Leng M, Jain A, Piyarathna B, Liu J, Song X, Zhang J, Klekers AR, Drake JM, Ittmann MM, Coarfa C, Piwnica-Worms D, Farach-Carson MC, Loda M, Eberlin LS, Frigo DE. Cancer Res. 2024 Mar 4;84(5):703-724. doi: 10.1158/0008-5472.CAN-23-0555. PubMed |
| Targeting ABCA12-controlled ceramide homeostasis inhibits breast cancer stem cell function and chemoresistance. Cui J, Christin JR, Reisz JA, Cendali FI, Sanawar R, Coutinho De Miranda M, D'Alessandro A, Guo W. Sci Adv. 2023 Dec;9(48):eadh1891. doi: 10.1126/sciadv.adh1891. Epub 2023 Dec 1. PubMed |
| UBE3C Facilitates the ER-Associated and Peripheral Degradation of Misfolded CFTR. Kamada Y, Tateishi H, Nakayamada U, Hinata D, Iwasaki A, Zhu J, Fukuda R, Okiyoneda T. Cells. 2023 Nov 30;12(23):2741. doi: 10.3390/cells12232741. PubMed |
| Combined BET and MEK Inhibition synergistically suppresses melanoma by targeting YAP1. Hu R, Hou H, Li Y, Zhang M, Li X, Chen Y, Guo Y, Sun H, Zhao S, Liao M, Cao D, Yan Q, Chen X, Yin M. Theranostics. 2024 Jan 1;14(2):593-607. doi: 10.7150/thno.85437. eCollection 2024. PubMed |
| c-Fos regulated by TMPO/ERK axis promotes 5-FU resistance via inducing NANOG transcription in colon cancer. Gui Y, Qian X, Ding Y, Chen Q, Fangyu Ye, Ye Y, Hou Y, Yu J, Zhao L. Cell Death Dis. 2024 Jan 17;15(1):61. doi: 10.1038/s41419-024-06451-w. PubMed |
| Lysyl Oxidase Regulates Epithelial Differentiation and Barrier Integrity in Eosinophilic Esophagitis. Sasaki M, Hara T, Wang JX, Zhou Y, Kennedy KV, Umeweni CN, Alston MA, Spergel ZC, Ishikawa S, Teranishi R, Nakagawa R, Mcmillan EA, Whelan KA, Karakasheva TA, Hamilton KE, Ruffner MA, Muir AB. Cell Mol Gastroenterol Hepatol. 2024;17(6):923-937. doi: 10.1016/j.jcmgh.2024.01.025. Epub 2024 Feb 9. PubMed |
An engineered biosensor enables dynamic aspartate measurements in living cells.
Davidsen K, Marvin JS, Aggarwal A, Brown TA, Sullivan LB.
eLife. 2024 Feb 23;12:RP90024. doi: 10.7554/eLife.90024.
PubMed
Associated Plasmids |
| Targeting Tryptophan Catabolism in Ovarian Cancer to Attenuate Macrophage Infiltration and PD-L1 Expression. Crump LS, Floyd JL, Kuo LW, Post MD, Bickerdike M, O'Neill K, Sompel K, Jordan KR, Corr BR, Marjon N, Woodruff ER, Richer JK, Bitler BG. Cancer Res Commun. 2024 Mar 18;4(3):822-833. doi: 10.1158/2767-9764.CRC-23-0513. PubMed |
| Context-dependent roles for ubiquitous mitochondrial creatine kinase CKMT1 in breast cancer progression. Ayyappan V, Jenkinson NM, Tressler CM, Tan Z, Cheng M, Shen XE, Guerrero A, Sonkar K, Cai R, Adelaja O, Roy S, Meeker A, Argani P, Glunde K. Cell Rep. 2024 Apr 23;43(4):114121. doi: 10.1016/j.celrep.2024.114121. Epub 2024 Apr 12. PubMed |
| Ligand-based virtual-screening identified a novel CFTR ligand which improves the defective cell surface expression of misfolded ABC transporters. Taniguchi S, Berenger F, Doi Y, Mimura A, Yamanishi Y, Okiyoneda T. Front Pharmacol. 2024 Apr 11;15:1370676. doi: 10.3389/fphar.2024.1370676. eCollection 2024. PubMed |
| A Novel Class of Human ADAM8 Inhibitory Antibodies for Treatment of Triple-Negative Breast Cancer. Mineva ND, Pianetti S, Das SG, Srinivasan S, Billiald NM, Sonenshein GE. Pharmaceutics. 2024 Apr 13;16(4):536. doi: 10.3390/pharmaceutics16040536. PubMed |
| ALK inhibitors suppress HCC and synergize with anti-PD-1 therapy and ABT-263 in preclinical models. Bugide S, Reddy DS, Malvi P, Gupta R, Wajapeyee N. iScience. 2024 Apr 23;27(5):109800. doi: 10.1016/j.isci.2024.109800. eCollection 2024 May 17. PubMed |
If you have published an article using this material, please email us at [email protected] to have your article added to this page.