Tet-pLKO-puro Citations (352)

Originally described in: Single-vector inducible lentiviral RNAi system for oncology target validation.
Wiederschain D, Wee S, Chen L, Loo A, Yang G, Huang A, Chen Y, Caponigro G, Yao YM, Lengauer C, Sellers WR, Benson JD Cell Cycle. 2009 Feb 1. 8(3):498-504. PubMed Journal

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Articles Citing Tet-pLKO-puro

Articles
Bone morphogenetic protein 7 in dormancy and metastasis of prostate cancer stem-like cells in bone. Kobayashi A, Okuda H, Xing F, Pandey PR, Watabe M, Hirota S, Pai SK, Liu W, Fukuda K, Chambers C, Wilber A, Watabe K. J Exp Med. 2011 Dec 19;208(13):2641-55. doi: 10.1084/jem.20110840. Epub 2011 Nov 28. PubMed
Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer. Rudin CM, Durinck S, Stawiski EW, Poirier JT, Modrusan Z, Shames DS, Bergbower EA, Guan Y, Shin J, Guillory J, Rivers CS, Foo CK, Bhatt D, Stinson J, Gnad F, Haverty PM, Gentleman R, Chaudhuri S, Janakiraman V, Jaiswal BS, Parikh C, Yuan W, Zhang Z, Koeppen H, Wu TD, Stern HM, Yauch RL, Huffman KE, Paskulin DD, Illei PB, Varella-Garcia M, Gazdar AF, de Sauvage FJ, Bourgon R, Minna JD, Brock MV, Seshagiri S. Nat Genet. 2012 Oct;44(10):1111-6. doi: 10.1038/ng.2405. Epub 2012 Sep 2. PubMed Associated Plasmids Tet-pLKO-puro-SOX2 Tet-pLKO-puro-Scrambled
Cysteine 70 of ankyrin-G is S-palmitoylated and is required for function of ankyrin-G in membrane domain assembly. He M, Jenkins P, Bennett V. J Biol Chem. 2012 Dec 21;287(52):43995-4005. doi: 10.1074/jbc.M112.417501. Epub 2012 Nov 5. PubMed
Inhibition of TWIST1 leads to activation of oncogene-induced senescence in oncogene-driven non-small cell lung cancer. Burns TF, Dobromilskaya I, Murphy SC, Gajula RP, Thiyagarajan S, Chatley SN, Aziz K, Cho YJ, Tran PT, Rudin CM. Mol Cancer Res. 2013 Apr;11(4):329-38. doi: 10.1158/1541-7786.MCR-12-0456. Epub 2013 Jan 30. PubMed
RNAi screens in mice identify physiological regulators of oncogenic growth. Beronja S, Janki P, Heller E, Lien WH, Keyes BE, Oshimori N, Fuchs E. Nature. 2013 Sep 12;501(7466):185-90. doi: 10.1038/nature12464. Epub 2013 Aug 14. PubMed
Sal-like 4 (SALL4) suppresses CDH1 expression and maintains cell dispersion in basal-like breast cancer. Itou J, Matsumoto Y, Yoshikawa K, Toi M. FEBS Lett. 2013 Sep 17;587(18):3115-21. doi: 10.1016/j.febslet.2013.07.049. Epub 2013 Aug 14. PubMed
Inhibiting glutamine uptake represents an attractive new strategy for treating acute myeloid leukemia. Willems L, Jacque N, Jacquel A, Neveux N, Maciel TT, Lambert M, Schmitt A, Poulain L, Green AS, Uzunov M, Kosmider O, Radford-Weiss I, Moura IC, Auberger P, Ifrah N, Bardet V, Chapuis N, Lacombe C, Mayeux P, Tamburini J, Bouscary D. Blood. 2013 Nov 14;122(20):3521-32. doi: 10.1182/blood-2013-03-493163. Epub 2013 Sep 6. PubMed
MUC1-C oncoprotein activates ERK-->C/EBPbeta signaling and induction of aldehyde dehydrogenase 1A1 in breast cancer cells. Alam M, Ahmad R, Rajabi H, Kharbanda A, Kufe D. J Biol Chem. 2013 Oct 25;288(43):30892-903. doi: 10.1074/jbc.M113.477158. Epub 2013 Sep 16. PubMed
Chromatin modifications sequentially enhance ErbB2 expression in ErbB2-positive breast cancers. Mungamuri SK, Murk W, Grumolato L, Bernstein E, Aaronson SA. Cell Rep. 2013 Oct 31;5(2):302-13. doi: 10.1016/j.celrep.2013.09.009. Epub 2013 Oct 10. PubMed
Genomic occupancy of Runx2 with global expression profiling identifies a novel dimension to control of osteoblastogenesis. Wu H, Whitfield TW, Gordon JA, Dobson JR, Tai PW, van Wijnen AJ, Stein JL, Stein GS, Lian JB. Genome Biol. 2014 Mar 21;15(3):R52. doi: 10.1186/gb-2014-15-3-r52. PubMed
Counteracting activities of OCT4 and KLF4 during reprogramming to pluripotency. Tiemann U, Marthaler AG, Adachi K, Wu G, Fischedick GU, Arauzo-Bravo MJ, Scholer HR, Tapia N. Stem Cell Reports. 2014 Feb 20;2(3):351-65. doi: 10.1016/j.stemcr.2014.01.005. eCollection 2014 Mar 11. PubMed
Protein and nucleotide biosynthesis are coupled by a single rate-limiting enzyme, PRPS2, to drive cancer. Cunningham JT, Moreno MV, Lodi A, Ronen SM, Ruggero D. Cell. 2014 May 22;157(5):1088-103. doi: 10.1016/j.cell.2014.03.052. PubMed
Quantitative phosphoproteomics reveals novel phosphorylation events in insulin signaling regulated by protein phosphatase 1 regulatory subunit 12A. Zhang X, Ma D, Caruso M, Lewis M, Qi Y, Yi Z. J Proteomics. 2014 Sep 23;109:63-75. doi: 10.1016/j.jprot.2014.06.010. Epub 2014 Jun 25. PubMed
Ash2L enables P53-dependent apoptosis by favoring stable transcription pre-initiation complex formation on its pro-apoptotic target promoters. Mungamuri SK, Wang S, Manfredi JJ, Gu W, Aaronson SA. Oncogene. 2015 May 7;34(19):2461-70. doi: 10.1038/onc.2014.198. Epub 2014 Jul 14. PubMed
SOX2 is a cancer-specific regulator of tumour initiating potential in cutaneous squamous cell carcinoma. Siegle JM, Basin A, Sastre-Perona A, Yonekubo Y, Brown J, Sennett R, Rendl M, Tsirigos A, Carucci JA, Schober M. Nat Commun. 2014 Jul 31;5:4511. doi: 10.1038/ncomms5511. PubMed
The polyomavirus middle T-antigen oncogene activates the Hippo pathway tumor suppressor Lats in a Src-dependent manner. Shanzer M, Ricardo-Lax I, Keshet R, Reuven N, Shaul Y. Oncogene. 2014 Nov 3. doi: 10.1038/onc.2014.347. PubMed
Targeting CREB inhibits radiation-induced neuroendocrine differentiation and increases radiation-induced cell death in prostate cancer cells. Suarez CD, Deng X, Hu CD. Am J Cancer Res. 2014 Nov 19;4(6):850-61. eCollection 2014. PubMed
A THEMIS:SHP1 complex promotes T-cell survival. Paster W, Bruger AM, Katsch K, Gregoire C, Roncagalli R, Fu G, Gascoigne NR, Nika K, Cohnen A, Feller SM, Simister PC, Molder KC, Cordoba SP, Dushek O, Malissen B, Acuto O. EMBO J. 2015 Feb 3;34(3):393-409. doi: 10.15252/embj.201387725. Epub 2014 Dec 22. PubMed
RELB Alters Proliferation of Human Pluripotent Stem Cells via IMP3- and LIN28-Mediated Modulation of the Expression of IGF2 and Other Cell-Cycle Regulators. Thakar NY, Ovchinnikov DA, Hastie ML, Gorman J, Wolvetang EJ. Stem Cells Dev. 2015 May 5. PubMed
HIF2alpha-Dependent Lipid Storage Promotes Endoplasmic Reticulum Homeostasis in Clear-Cell Renal Cell Carcinoma. Qiu B, Ackerman D, Sanchez DJ, Li B, Ochocki JD, Grazioli A, Bobrovnikova-Marjon E, Diehl JA, Keith B, Simon MC. Cancer Discov. 2015 Jun;5(6):652-67. doi: 10.1158/2159-8290.CD-14-1507. Epub 2015 Mar 31. PubMed
Caveolin-1 is transcribed from a hypermethylated promoter to mediate colonocyte differentiation and apoptosis. Dasgupta N, Kumar Thakur B, Ta A, Das S. Exp Cell Res. 2015 Jun 10;334(2):323-36. doi: 10.1016/j.yexcr.2015.03.020. Epub 2015 Apr 1. PubMed
Co-activation of AMPK and mTORC1 Induces Cytotoxicity in Acute Myeloid Leukemia. Sujobert P, Poulain L, Paubelle E, Zylbersztejn F, Grenier A, Lambert M, Townsend EC, Brusq JM, Nicodeme E, Decrooqc J, Nepstad I, Green AS, Mondesir J, Hospital MA, Jacque N, Christodoulou A, Desouza TA, Hermine O, Foretz M, Viollet B, Lacombe C, Mayeux P, Weinstock DM, Moura IC, Bouscary D, Tamburini J. Cell Rep. 2015 Jun 9;11(9):1446-57. doi: 10.1016/j.celrep.2015.04.063. Epub 2015 May 21. PubMed
Secreted Frizzled-Related Protein 3 (SFRP3) Is Required for Tumorigenesis of PAX3-FOXO1-Positive Alveolar Rhabdomyosarcoma. Kephart JJ, Tiller RG, Crose LE, Slemmons KK, Chen PH, Hinson AR, Bentley RC, Chi JT, Linardic CM. Clin Cancer Res. 2015 Nov 1;21(21):4868-80. doi: 10.1158/1078-0432.CCR-14-1797. Epub 2015 Jun 12. PubMed
Transcription Factor ATF4 Induces NLRP1 Inflammasome Expression during Endoplasmic Reticulum Stress. D'Osualdo A, Anania VG, Yu K, Lill JR, Kaufman RJ, Matsuzawa S, Reed JC. PLoS One. 2015 Jun 18;10(6):e0130635. doi: 10.1371/journal.pone.0130635. eCollection 2015. PubMed
Deficiency in mTORC1-controlled C/EBPbeta-mRNA translation improves metabolic health in mice. Zidek LM, Ackermann T, Hartleben G, Eichwald S, Kortman G, Kiehntopf M, Leutz A, Sonenberg N, Wang ZQ, von Maltzahn J, Muller C, Calkhoven CF. EMBO Rep. 2015 Aug;16(8):1022-36. doi: 10.15252/embr.201439837. Epub 2015 Jun 25. PubMed
A long non-coding RNA, LncMyoD, regulates skeletal muscle differentiation by blocking IMP2-mediated mRNA translation. Gong C, Li Z, Ramanujan K, Clay I, Zhang Y, Lemire-Brachat S, Glass DJ. Dev Cell. 2015 Jul 27;34(2):181-91. doi: 10.1016/j.devcel.2015.05.009. Epub 2015 Jul 2. PubMed
Targeting glutaminolysis has antileukemic activity in acute myeloid leukemia and synergizes with BCL-2 inhibition. Jacque N, Ronchetti AM, Larrue C, Meunier G, Birsen R, Willems L, Saland E, Decroocq J, Thiago TT, Lambert M, Poulain L, Hospital MA, Sujobert P, Joseph L, Chapuis N, Lacombe C, Moura IC, Demo S, Sarry JE, Recher C, Mayeux P, Tamburini J, Bouscary D. Blood. 2015 Sep 10;126(11):1346-56. doi: 10.1182/blood-2015-01-621870. Epub 2015 Jul 17. PubMed
alpha-5 Laminin Synthesized by Human Pluripotent Stem Cells Promotes Self-Renewal. Laperle A, Hsiao C, Lampe M, Mortier J, Saha K, Palecek SP, Masters KS. Stem Cell Reports. 2015 Aug 11;5(2):195-206. doi: 10.1016/j.stemcr.2015.06.009. Epub 2015 Jul 30. PubMed
Targeting the mRNA-binding protein HuR impairs malignant characteristics of pancreatic ductal adenocarcinoma cells. Jimbo M, Blanco FF, Huang YH, Telonis AG, Screnci BA, Cosma GL, Alexeev V, Gonye GE, Yeo CJ, Sawicki JA, Winter JM, Brody JR. Oncotarget. 2015 Sep 29;6(29):27312-31. doi: 10.18632/oncotarget.4743. PubMed
Pim kinases modulate resistance to FLT3 tyrosine kinase inhibitors in FLT3-ITD acute myeloid leukemia. Green AS, Maciel TT, Hospital MA, Yin C, Mazed F, Townsend EC, Pilorge S, Lambert M, Paubelle E, Jacquel A, Zylbersztejn F, Decroocq J, Poulain L, Sujobert P, Jacque N, Adam K, So JC, Kosmider O, Auberger P, Hermine O, Weinstock DM, Lacombe C, Mayeux P, Vanasse GJ, Leung AY, Moura IC, Bouscary D, Tamburini J. Sci Adv. 2015 Sep 18;1(8):e1500221. doi: 10.1126/sciadv.1500221. eCollection 2015 Sep. PubMed
Human pluripotent stem cell culture density modulates YAP signaling. Hsiao C, Lampe M, Nillasithanukroh S, Han W, Lian X, Palecek SP. Biotechnol J. 2016 Jan 14. doi: 10.1002/biot.201500374. PubMed
Assessment of costimulation and coinhibition in a triple parameter T cell reporter line: Simultaneous measurement of NF-kappaB, NFAT and AP-1. Jutz S, Leitner J, Schmetterer K, Doel-Perez I, Majdic O, Grabmeier-Pfistershammer K, Paster W, Huppa JB, Steinberger P. J Immunol Methods. 2016 Jan 15. pii: S0022-1759(16)30007-2. doi: 10.1016/j.jim.2016.01.007. PubMed Associated Plasmids pSIRV-NFAT-eGFP pSIRV-NF-kB-eCFP pSIRV-AP-1-mCherry
Endoplasmic reticulum stress drives proteinuria-induced kidney lesions via Lipocalin 2. El Karoui K, Viau A, Dellis O, Bagattin A, Nguyen C, Baron W, Burtin M, Broueilh M, Heidet L, Mollet G, Druilhe A, Antignac C, Knebelmann B, Friedlander G, Bienaime F, Gallazzini M, Terzi F. Nat Commun. 2016 Jan 20;7:10330. doi: 10.1038/ncomms10330. PubMed
PRDX2 and PRDX4 are negative regulators of hypoxia-inducible factors under conditions of prolonged hypoxia. Luo W, Chen I, Chen Y, Alkam D, Wang Y, Semenza GL. Oncotarget. 2016 Feb 9;7(6):6379-97. doi: 10.18632/oncotarget.7142. PubMed
Functional interactions of the cystine/glutamate antiporter, CD44v and MUC1-C oncoprotein in triple-negative breast cancer cells. Hasegawa M, Takahashi H, Rajabi H, Alam M, Suzuki Y, Yin L, Tagde A, Maeda T, Hiraki M, Sukhatme VP, Kufe D. Oncotarget. 2016 Mar 15;7(11):11756-69. doi: 10.18632/oncotarget.7598. PubMed
Activation of PKA leads to mesenchymal-to-epithelial transition and loss of tumor-initiating ability. Pattabiraman DR, Bierie B, Kober KI, Thiru P, Krall JA, Zill C, Reinhardt F, Tam WL, Weinberg RA. Science. 2016 Mar 4;351(6277):aad3680. doi: 10.1126/science.aad3680. PubMed Associated Plasmids pLIX402 PHF2 pLIX402 caPHF2 7TFP CDH1 mutant reporter 7TFP CDH1 reporter
USP7 Enforces Heterochromatinization of p53 Target Promoters by Protecting SUV39H1 from MDM2-Mediated Degradation. Mungamuri SK, Qiao RF, Yao S, Manfredi JJ, Gu W, Aaronson SA. Cell Rep. 2016 Mar 22;14(11):2528-37. doi: 10.1016/j.celrep.2016.02.049. Epub 2016 Mar 10. PubMed
DEPTOR promotes survival of cervical squamous cell carcinoma cells and its silencing induces apoptosis through downregulating PI3K/AKT and by up-regulating p38 MAP kinase. Srinivas KP, Viji R, Dan VM, Sajitha IS, Prakash R, Rahul PV, Santhoshkumar TR, Lakshmi S, Pillai MR. Oncotarget. 2016 Apr 26;7(17):24154-71. doi: 10.18632/oncotarget.8131. PubMed
Identification of PRKDC (Protein Kinase, DNA-Activated, Catalytic Polypeptide) as an essential gene for colorectal cancer (CRCs) cells. Sun S, Cheng S, Zhu Y, Zhang P, Liu N, Xu T, Sun C, Lv Y. Gene. 2016 Jun 10;584(1):90-6. doi: 10.1016/j.gene.2016.03.020. Epub 2016 Mar 15. PubMed
ISL1 and JMJD3 synergistically control cardiac differentiation of embryonic stem cells. Wang Y, Li Y, Guo C, Lu Q, Wang W, Jia Z, Chen P, Ma K, Reinberg D, Zhou C. Nucleic Acids Res. 2016 Apr 21. pii: gkw301. PubMed
MUC1-C Stabilizes MCL-1 in the Oxidative Stress Response of Triple-Negative Breast Cancer Cells to BCL-2 Inhibitors. Hiraki M, Suzuki Y, Alam M, Hinohara K, Hasegawa M, Jin C, Kharbanda S, Kufe D. Sci Rep. 2016 May 24;6:26643. doi: 10.1038/srep26643. PubMed
TCF7L1 Modulates Colorectal Cancer Growth by Inhibiting Expression of the Tumor-Suppressor Gene EPHB3. Murphy M, Chatterjee SS, Jain S, Katari M, DasGupta R. Sci Rep. 2016 Jun 23;6:28299. doi: 10.1038/srep28299. PubMed
Sur8 mediates tumorigenesis and metastasis in colorectal cancer. Lee YM, Kaduwal S, Lee KH, Park JC, Jeong WJ, Choi KY. Exp Mol Med. 2016 Jul 29;48(7):e249. doi: 10.1038/emm.2016.58. PubMed
Stratification and therapeutic potential of PML in metastatic breast cancer. Martin-Martin N, Piva M, Urosevic J, Aldaz P, Sutherland JD, Fernandez-Ruiz S, Arreal L, Torrano V, Cortazar AR, Planet E, Guiu M, Radosevic-Robin N, Garcia S, Macias I, Salvador F, Domenici G, Rueda OM, Zabala-Letona A, Arruabarrena-Aristorena A, Zuniga-Garcia P, Caro-Maldonado A, Valcarcel-Jimenez L, Sanchez-Mosquera P, Varela-Rey M, Martinez-Chantar ML, Anguita J, Ibrahim YH, Scaltriti M, Lawrie CH, Aransay AM, Iovanna JL, Baselga J, Caldas C, Barrio R, Serra V, Vivanco Md, Matheu A, Gomis RR, Carracedo A. Nat Commun. 2016 Aug 24;7:12595. doi: 10.1038/ncomms12595. PubMed
MUC1-C Represses the Crumbs Complex Polarity Factor CRB3 and Downregulates the Hippo Pathway. Alam M, Bouillez A, Tagde A, Ahmad R, Rajabi H, Maeda T, Hiraki M, Suzuki Y, Kufe D. Mol Cancer Res. 2016 Dec;14(12):1266-1276. Epub 2016 Sep 22. PubMed
c-MYC drives histone demethylase PHF8 during neuroendocrine differentiation and in castration-resistant prostate cancer. Maina PK, Shao P, Liu Q, Fazli L, Tyler S, Nasir M, Dong X, Qi HH. Oncotarget. 2016 Nov 15;7(46):75585-75602. doi: 10.18632/oncotarget.12310. PubMed
Tumors overexpressing RNF168 show altered DNA repair and responses to genotoxic treatments, genomic instability and resistance to proteotoxic stress. Chroma K, Mistrik M, Moudry P, Gursky J, Liptay M, Strauss R, Skrott Z, Vrtel R, Bartkova J, Kramara J, Bartek J. Oncogene. 2016 Nov 14. doi: 10.1038/onc.2016.392. PubMed
Mitochondrial Sirtuin Network Reveals Dynamic SIRT3-Dependent Deacetylation in Response to Membrane Depolarization. Yang W, Nagasawa K, Munch C, Xu Y, Satterstrom K, Jeong S, Hayes SD, Jedrychowski MP, Vyas FS, Zaganjor E, Guarani V, Ringel AE, Gygi SP, Harper JW, Haigis MC. Cell. 2016 Nov 3;167(4):985-1000.e21. doi: 10.1016/j.cell.2016.10.016. Epub 2016 Oct 27. PubMed
Identification of MYST3 as a novel epigenetic activator of ERalpha frequently amplified in breast cancer. Yu L, Liang Y, Cao X, Wang X, Gao H, Lin SY, Schiff R, Wang XS, Li K. Oncogene. 2016 Nov 28. doi: 10.1038/onc.2016.433. PubMed
MUC1-C activates BMI1 in human cancer cells. Hiraki M, Maeda T, Bouillez A, Alam M, Tagde A, Hinohara K, Suzuki Y, Markert T, Miyo M, Komura K, Ahmad R, Rajabi H, Kufe D. Oncogene. 2016 Nov 28. doi: 10.1038/onc.2016.439. PubMed
Core binding factor (CBF) is required for Epstein-Barr virus EBNA3 proteins to regulate target gene expression. Paschos K, Bazot Q, Ho G, Parker GA, Lees J, Barton G, Allday MJ. Nucleic Acids Res. 2016 Nov 29. pii: gkw1167. PubMed
Identification of apilimod as a first-in-class PIKfyve kinase inhibitor for treatment of B-cell non-Hodgkin lymphoma. Gayle S, Landrette S, Beeharry N, Conrad C, Hernandez M, Beckett P, Ferguson SM, Mandelkern T, Zheng M, Xu T, Rothberg J, Lichenstein H. Blood. 2017 Mar 30;129(13):1768-1778. doi: 10.1182/blood-2016-09-736892. Epub 2017 Jan 19. PubMed
Snail reprograms glucose metabolism by repressing phosphofructokinase PFKP allowing cancer cell survival under metabolic stress. Kim NH, Cha YH, Lee J, Lee SH, Yang JH, Yun JS, Cho ES, Zhang X, Nam M, Kim N, Yuk YS, Cha SY, Lee Y, Ryu JK, Park S, Cheong JH, Kang SW, Kim SY, Hwang GS, Yook JI, Kim HS. Nat Commun. 2017 Feb 8;8:14374. doi: 10.1038/ncomms14374. PubMed
Copy-number and gene dependency analysis reveals partial copy loss of wild-type SF3B1 as a novel cancer vulnerability. Paolella BR, Gibson WJ, Urbanski LM, Alberta JA, Zack TI, Bandopadhayay P, Nichols CA, Agarwalla PK, Brown MS, Lamothe R, Yu Y, Choi PS, Obeng EA, Heckl D, Wei G, Wang B, Tsherniak A, Vazquez F, Weir BA, Root DE, Cowley GS, Buhrlage SJ, Stiles CD, Ebert BL, Hahn WC, Reed R, Beroukhim R. Elife. 2017 Feb 8;6. doi: 10.7554/eLife.23268. PubMed
A screening strategy for the discovery of drugs that reduce C/EBPbeta-LIP translation with potential calorie restriction mimetic properties. Zaini MA, Muller C, Ackermann T, Reinshagen J, Kortman G, Pless O, Calkhoven CF. Sci Rep. 2017 Feb 15;7:42603. doi: 10.1038/srep42603. PubMed
HOXC8 regulates self-renewal, differentiation and transformation of breast cancer stem cells. Shah M, Cardenas R, Wang B, Persson J, Mongan NP, Grabowska A, Allegrucci C. Mol Cancer. 2017 Feb 16;16(1):38. doi: 10.1186/s12943-017-0605-z. PubMed
MELK expression in ovarian cancer correlates with poor outcome and its inhibition by OTSSP167 abrogates proliferation and viability of ovarian cancer cells. Kohler RS, Kettelhack H, Knipprath-Meszaros AM, Fedier A, Schoetzau A, Jacob F, Heinzelmann-Schwarz V. Gynecol Oncol. 2017 Apr;145(1):159-166. doi: 10.1016/j.ygyno.2017.02.016. Epub 2017 Feb 14. PubMed
A streamlined method for the design and cloning of shRNAs into an optimized Dox-inducible lentiviral vector. Frank SB, Schulz VV, Miranti CK. BMC Biotechnol. 2017 Feb 28;17(1):24. doi: 10.1186/s12896-017-0341-x. PubMed Associated Plasmids EZ-Tet-pLKO-Puro EZ-Tet-pLKO-Hygro EZ-Tet-pLKO-Blast
High mTORC1 activity drives glycolysis addiction and sensitivity to G6PD inhibition in acute myeloid leukemia cells. Poulain L, Sujobert P, Zylbersztejn F, Barreau S, Stuani L, Lambert M, Palama TL, Chesnais V, Birsen R, Vergez F, Farge T, Chenevier-Gobeaux C, Fraisse M, Bouillaud F, Debeissat C, Herault O, Recher C, Lacombe C, Fontenay M, Mayeux P, Maciel TT, Portais JC, Sarry JE, Tamburini J, Bouscary D, Chapuis N. Leukemia. 2017 Nov;31(11):2326-2335. doi: 10.1038/leu.2017.81. Epub 2017 Mar 10. PubMed
Niclosamide is a potential therapeutic for familial adenomatosis polyposis by disrupting Axin-GSK3 interaction. Ahn SY, Kim NH, Lee K, Cha YH, Yang JH, Cha SY, Cho ES, Lee Y, Cha JS, Cho HS, Jeon Y, Yuk YS, Cho S, No KT, Kim HS, Lee H, Choi J, Yook JI. Oncotarget. 2017 May 9;8(19):31842-31855. doi: 10.18632/oncotarget.16252. PubMed
TCF7L1 promotes skin tumorigenesis independently of beta-catenin through induction of LCN2. Ku AT, Shaver TM, Rao AS, Howard JM, Rodriguez CN, Miao Q, Garcia G, Le D, Yang D, Borowiak M, Cohen DN, Chitsazzadeh V, Diwan AH, Tsai KY, Nguyen H. Elife. 2017 May 3;6. pii: e23242. doi: 10.7554/eLife.23242. PubMed
mTORC1-independent autophagy regulates receptor tyrosine kinase phosphorylation in colorectal cancer cells via an mTORC2-mediated mechanism. Lampada A, O'Prey J, Szabadkai G, Ryan KM, Hochhauser D, Salomoni P. Cell Death Differ. 2017 Jun;24(6):1045-1062. doi: 10.1038/cdd.2017.41. Epub 2017 May 5. PubMed
A clinical drug library screen identifies clobetasol propionate as an NRF2 inhibitor with potential therapeutic efficacy in KEAP1 mutant lung cancer. Choi EJ, Jung BJ, Lee SH, Yoo HS, Shin EA, Ko HJ, Chang S, Kim SY, Jeon SM. Oncogene. 2017 Sep 14;36(37):5285-5295. doi: 10.1038/onc.2017.153. Epub 2017 May 15. PubMed
Role of NF-E2 related factor 2 (Nrf2) on chemotherapy resistance in acute myeloid leukemia (AML) and the effect of pharmacological inhibition of Nrf2. Karathedath S, Rajamani BM, Musheer Aalam SM, Abraham A, Varatharajan S, Krishnamurthy P, Mathews V, Velayudhan SR, Balasubramanian P. PLoS One. 2017 May 15;12(5):e0177227. doi: 10.1371/journal.pone.0177227. eCollection 2017. PubMed
Nuclear Pores Regulate Muscle Development and Maintenance by Assembling a Localized Mef2C Complex. Raices M, Bukata L, Sakuma S, Borlido J, Hernandez LS, Hart DO, D'Angelo MA. Dev Cell. 2017 Jun 5;41(5):540-554.e7. doi: 10.1016/j.devcel.2017.05.007. PubMed
Cyclosporine A-Mediated IL-6 Expression Promotes Neural Induction in Pluripotent Stem Cells. Ashwini A, Naganur SS, Smitha B, Sheshadri P, Prasanna J, Kumar A. Mol Neurobiol. 2017 Jun 16. doi: 10.1007/s12035-017-0633-0. PubMed
Posttranscriptional upregulation of IDH1 by HuR establishes a powerful survival phenotype in pancreatic cancer cells. Zarei M, Lal S, Parker SJ, Nevler A, Vaziri-Gohar A, Dukleska K, Mambelli-Lisboa NC, Moffat C, Blanco FF, Chand SN, Jimbo M, Cozzitorto JA, Jiang W, Yeo CJ, Londin E, Seifert EL, Metallo CM, Brody JR, Winter JM. Cancer Res. 2017 Jun 26. pii: canres.0015.2017. doi: 10.1158/0008-5472.CAN-17-0015. PubMed
mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer. Zabala-Letona A, Arruabarrena-Aristorena A, Martin-Martin N, Fernandez-Ruiz S, Sutherland JD, Clasquin M, Tomas-Cortazar J, Jimenez J, Torres I, Quang P, Ximenez-Embun P, Bago R, Ugalde-Olano A, Loizaga-Iriarte A, Lacasa-Viscasillas I, Unda M, Torrano V, Cabrera D, van Liempd SM, Cendon Y, Castro E, Murray S, Revandkar A, Alimonti A, Zhang Y, Barnett A, Lein G, Pirman D, Cortazar AR, Arreal L, Prudkin L, Astobiza I, Valcarcel-Jimenez L, Zuniga-Garcia P, Fernandez-Dominguez I, Piva M, Caro-Maldonado A, Sanchez-Mosquera P, Castillo-Martin M, Serra V, Beraza N, Gentilella A, Thomas G, Azkargorta M, Elortza F, Farras R, Olmos D, Efeyan A, Anguita J, Munoz J, Falcon-Perez JM, Barrio R, Macarulla T, Mato JM, Martinez-Chantar ML, Cordon-Cardo C, Aransay AM, Marks K, Baselga J, Tabernero J, Nuciforo P, Manning BD, Marjon K, Carracedo A. Nature. 2017 Jul 6;547(7661):109-113. doi: 10.1038/nature22964. Epub 2017 Jun 28. PubMed
Huwe1 sustains normal ovarian epithelial cell transformation and tumor growth through the histone H1.3-H19 cascade. Yang D, Sun B, Zhang X, Cheng D, Yu X, Yan L, Li L, An S, Jiang H, Lasorella A, Iavarone A, Zhang S, Zou F, Zhao X. Cancer Res. 2017 Jul 7. pii: canres.2597.2016. doi: 10.1158/0008-5472.CAN-16-2597. PubMed
Histone demethylase PHF8 regulates hypoxia signaling through HIF1alpha and H3K4me3. Maina PK, Shao P, Jia X, Liu Q, Umesalma S, Marin M, Long D Jr, Concepcion-Roman S, Qi HH. Biochim Biophys Acta Gene Regul Mech. 2017 Sep;1860(9):1002-1012. doi: 10.1016/j.bbagrm.2017.07.005. Epub 2017 Jul 20. PubMed
MUC1-C activates EZH2 expression and function in human cancer cells. Rajabi H, Hiraki M, Tagde A, Alam M, Bouillez A, Christensen CL, Samur M, Wong KK, Kufe D. Sci Rep. 2017 Aug 7;7(1):7481. doi: 10.1038/s41598-017-07850-0. PubMed
PDI is an essential redox-sensitive activator of PERK during the unfolded protein response (UPR). Kranz P, Neumann F, Wolf A, Classen F, Pompsch M, Ocklenburg T, Baumann J, Janke K, Baumann M, Goepelt K, Riffkin H, Metzen E, Brockmeier U. Cell Death Dis. 2017 Aug 10;8(8):e2986. doi: 10.1038/cddis.2017.369. PubMed
RSK2 is a new Pim2 target with pro-survival functions in FLT3-ITD-positive acute myeloid leukemia. Hospital MA, Jacquel A, Mazed F, Saland E, Larrue C, Mondesir J, Birsen R, Green AS, Lambert M, Sujobert P, Gautier EF, Salnot V, Le Gall M, Decroocq J, Poulain L, Jacque N, Fontenay M, Kosmider O, Recher C, Auberger P, Mayeux P, Bouscary D, Sarry JE, Tamburini J. Leukemia. 2018 Mar;32(3):597-605. doi: 10.1038/leu.2017.284. Epub 2017 Sep 15. PubMed
A Novel Notch-YAP Circuit Drives Stemness and Tumorigenesis in Embryonal Rhabdomyosarcoma. Slemmons KK, Crose LES, Riedel S, Sushnitha M, Belyea B, Linardic CM. Mol Cancer Res. 2017 Dec;15(12):1777-1791. doi: 10.1158/1541-7786.MCR-17-0004. Epub 2017 Sep 18. PubMed
MELK is not necessary for the proliferation of basal-like breast cancer cells. Huang HT, Seo HS, Zhang T, Wang Y, Jiang B, Li Q, Buckley DL, Nabet B, Roberts JM, Paulk J, Dastjerdi S, Winter GE, McLauchlan H, Moran J, Bradner JE, Eck MJ, Dhe-Paganon S, Zhao JJ, Gray NS. Elife. 2017 Sep 19;6. pii: e26693. doi: 10.7554/eLife.26693. PubMed Associated Plasmids tet-pLKO-sgRNA-puro
Merkel cell polyomavirus recruits MYCL to the EP400 complex to promote oncogenesis. Cheng J, Park DE, Berrios C, White EA, Arora R, Yoon R, Branigan T, Xiao T, Westerling T, Federation A, Zeid R, Strober B, Swanson SK, Florens L, Bradner JE, Brown M, Howley PM, Padi M, Washburn MP, DeCaprio JA. PLoS Pathog. 2017 Oct 13;13(10):e1006668. doi: 10.1371/journal.ppat.1006668. eCollection 2017 Oct. PubMed
Targeting MUC1-C suppresses polycomb repressive complex 1 in multiple myeloma. Tagde A, Markert T, Rajabi H, Hiraki M, Alam M, Bouillez A, Avigan D, Anderson K, Kufe D. Oncotarget. 2017 Aug 10;8(41):69237-69249. doi: 10.18632/oncotarget.20144. eCollection 2017 Sep 19. PubMed
SGK1 Is a Critical Component of an AKT-Independent Pathway Essential for PI3K-Mediated Tumor Development and Maintenance. Orlacchio A, Ranieri M, Brave M, Arciuch VA, Forde T, De Martino D, Anderson KE, Hawkins P, Di Cristofano A. Cancer Res. 2017 Dec 15;77(24):6914-6926. doi: 10.1158/0008-5472.CAN-17-2105. Epub 2017 Oct 20. PubMed
PAX2 maintains the differentiation of mouse oviductal epithelium and inhibits the transition to a stem cell-like state. Alwosaibai K, Abedini A, Al-Hujaily EM, Tang Y, Garson K, Collins O, Vanderhyden BC. Oncotarget. 2017 Aug 10;8(44):76881-76897. doi: 10.18632/oncotarget.20173. eCollection 2017 Sep 29. PubMed
NUPR1 maintains autolysosomal efflux by activating SNAP25 transcription in cancer cells. Mu Y, Yan X, Li D, Zhao D, Wang L, Wang X, Gao D, Yang J, Zhang H, Li Y, Sun Y, Wei Y, Zhang Z, Chang X, Yao Z, Tian S, Zhang K, Terada LS, Ma Z, Liu Z. Autophagy. 2018;14(4):654-670. doi: 10.1080/15548627.2017.1338556. Epub 2017 Dec 31. PubMed
Aberrant Activation of a Gastrointestinal Transcriptional Circuit in Prostate Cancer Mediates Castration Resistance. Shukla S, Cyrta J, Murphy DA, Walczak EG, Ran L, Agrawal P, Xie Y, Chen Y, Wang S, Zhan Y, Li D, Wong EWP, Sboner A, Beltran H, Mosquera JM, Sher J, Cao Z, Wongvipat J, Koche RP, Gopalan A, Zheng D, Rubin MA, Scher HI, Chi P, Chen Y. Cancer Cell. 2017 Dec 11;32(6):792-806.e7. doi: 10.1016/j.ccell.2017.10.008. Epub 2017 Nov 16. PubMed
Kruppel-like Factor 5, Increased in Pancreatic Ductal Adenocarcinoma, Promotes Proliferation, Acinar-to-Ductal Metaplasia, Pancreatic Intraepithelial Neoplasia, and Tumor Growth in Mice. He P, Yang JW, Yang VW, Bialkowska AB. Gastroenterology. 2018 Apr;154(5):1494-1508.e13. doi: 10.1053/j.gastro.2017.12.005. Epub 2017 Dec 15. PubMed
MUC1-C Induces PD-L1 and Immune Evasion in Triple-Negative Breast Cancer. Maeda T, Hiraki M, Jin C, Rajabi H, Tagde A, Alam M, Bouillez A, Hu X, Suzuki Y, Miyo M, Hata T, Hinohara K, Kufe D. Cancer Res. 2018 Jan 1;78(1):205-215. doi: 10.1158/0008-5472.CAN-17-1636. Epub 2017 Dec 20. PubMed
Oncogenic KRAS Regulates Amino Acid Homeostasis and Asparagine Biosynthesis via ATF4 and Alters Sensitivity to L-Asparaginase. Gwinn DM, Lee AG, Briones-Martin-Del-Campo M, Conn CS, Simpson DR, Scott AI, Le A, Cowan TM, Ruggero D, Sweet-Cordero EA. Cancer Cell. 2018 Jan 8;33(1):91-107.e6. doi: 10.1016/j.ccell.2017.12.003. PubMed
HNRNPH1 is required for rhabdomyosarcoma cell growth and survival. Li Y, Bakke J, Finkelstein D, Zeng H, Wu J, Chen T. Oncogenesis. 2018 Jan 24;7(1):9. doi: 10.1038/s41389-017-0024-4. PubMed
PAX3-FOXO1 drives miR-486-5p and represses miR-221 contributing to pathogenesis of alveolar rhabdomyosarcoma. Hanna JA, Garcia MR, Lardennois A, Leavey PJ, Maglic D, Fagnan A, Go JC, Roach J, Wang YD, Finkelstein D, Hatley ME. Oncogene. 2018 Apr;37(15):1991-2007. doi: 10.1038/s41388-017-0081-3. Epub 2018 Jan 25. PubMed
Inducibly decreased MITF levels do not affect proliferation and phenotype switching but reduce differentiation of melanoma cells. Vlckova K, Vachtenheim J, Reda J, Horak P, Ondrusova L. J Cell Mol Med. 2018 Apr;22(4):2240-2251. doi: 10.1111/jcmm.13506. Epub 2018 Jan 25. PubMed
EGFRvIII expression triggers a metabolic dependency and therapeutic vulnerability sensitive to autophagy inhibition. Jutten B, Keulers TG, Peeters HJM, Schaaf MBE, Savelkouls KGM, Compter I, Clarijs R, Schijns OEMG, Ackermans L, Teernstra OPM, Zonneveld MI, Colaris RME, Dubois L, Vooijs MA, Bussink J, Sotelo J, Theys J, Lammering G, Rouschop KMA. Autophagy. 2018;14(2):283-295. doi: 10.1080/15548627.2017.1409926. Epub 2018 Jan 29. PubMed
Truncated SALL1 Impedes Primary Cilia Function in Townes-Brocks Syndrome. Bozal-Basterra L, Martin-Ruiz I, Pirone L, Liang Y, Sigurethsson JO, Gonzalez-Santamarta M, Giordano I, Gabicagogeascoa E, de Luca A, Rodriguez JA, Wilkie AOM, Kohlhase J, Eastwood D, Yale C, Olsen JV, Rauchman M, Anderson KV, Sutherland JD, Barrio R. Am J Hum Genet. 2018 Feb 1;102(2):249-265. doi: 10.1016/j.ajhg.2017.12.017. PubMed
Antiviral and anti-inflammatory activity of budesonide against human rhinovirus infection mediated via autophagy activation. Kim SR, Song JH, Ahn JH, Lee GS, Ahn H, Yoon SI, Kang SG, Kim PH, Jeon SM, Choi EJ, Shin S, Cha Y, Cho S, Kim DE, Chang SY, Ko HJ. Antiviral Res. 2018 Mar;151:87-96. doi: 10.1016/j.antiviral.2018.01.012. Epub 2018 Feb 3. PubMed
Low-dose statin treatment increases prostate cancer aggressiveness. Caro-Maldonado A, Camacho L, Zabala-Letona A, Torrano V, Fernandez-Ruiz S, Zamacola-Bascaran K, Arreal L, Valcarcel-Jimenez L, Martin-Martin N, Flores JM, Cortazar AR, Zuniga-Garcia P, Arruabarrena-Aristorena A, Guillaumond F, Cabrera D, Falcon-Perez JM, Aransay AM, Gomez-Munoz A, Olivan M, Morote J, Carracedo A. Oncotarget. 2017 Oct 31;9(2):1494-1504. doi: 10.18632/oncotarget.22217. eCollection 2018 Jan 5. PubMed
The Transcriptional Coactivator TAZ Is a Potent Mediator of Alveolar Rhabdomyosarcoma Tumorigenesis. Deel MD, Slemmons KK, Hinson AR, Genadry KC, Burgess BA, Crose LES, Kuprasertkul N, Oristian KM, Bentley RC, Linardic CM. Clin Cancer Res. 2018 Jun 1;24(11):2616-2630. doi: 10.1158/1078-0432.CCR-17-1207. Epub 2018 Mar 7. PubMed
Genomic positional conservation identifies topological anchor point RNAs linked to developmental loci. Amaral PP, Leonardi T, Han N, Vire E, Gascoigne DK, Arias-Carrasco R, Buscher M, Pandolfini L, Zhang A, Pluchino S, Maracaja-Coutinho V, Nakaya HI, Hemberg M, Shiekhattar R, Enright AJ, Kouzarides T. Genome Biol. 2018 Mar 15;19(1):32. doi: 10.1186/s13059-018-1405-5. PubMed
Targeting MUC1-C suppresses BCL2A1 in triple-negative breast cancer. Hiraki M, Maeda T, Mehrotra N, Jin C, Alam M, Bouillez A, Hata T, Tagde A, Keating A, Kharbanda S, Singh H, Kufe D. Signal Transduct Target Ther. 2018 May 12;3:13. doi: 10.1038/s41392-018-0013-x. eCollection 2018. PubMed
Targetable vulnerabilities in T- and NK-cell lymphomas identified through preclinical models. Ng SY, Yoshida N, Christie AL, Ghandi M, Dharia NV, Dempster J, Murakami M, Shigemori K, Morrow SN, Van Scoyk A, Cordero NA, Stevenson KE, Puligandla M, Haas B, Lo C, Meyers R, Gao G, Cherniack A, Louissaint A Jr, Nardi V, Thorner AR, Long H, Qiu X, Morgan EA, Dorfman DM, Fiore D, Jang J, Epstein AL, Dogan A, Zhang Y, Horwitz SM, Jacobsen ED, Santiago S, Ren JG, Guerlavais V, Annis DA, Aivado M, Saleh MN, Mehta A, Tsherniak A, Root D, Vazquez F, Hahn WC, Inghirami G, Aster JC, Weinstock DM, Koch R. Nat Commun. 2018 May 22;9(1):2024. doi: 10.1038/s41467-018-04356-9. PubMed
Recurrent 8q24 rearrangement in blastic plasmacytoid dendritic cell neoplasm: association with immunoblastoid cytomorphology, MYC expression, and drug response. Sakamoto K, Katayama R, Asaka R, Sakata S, Baba S, Nakasone H, Koike S, Tsuyama N, Dobashi A, Sasaki M, Ichinohasama R, Takakuwa E, Yamazaki R, Takizawa J, Maeda T, Narita M, Izutsu K, Kanda Y, Ohshima K, Takeuchi K. Leukemia. 2018 Dec;32(12):2590-2603. doi: 10.1038/s41375-018-0154-5. Epub 2018 May 23. PubMed
Bidirectional regulation of adenosine-to-inosine (A-to-I) RNA editing by DEAH box helicase 9 (DHX9) in cancer. Hong H, An O, Chan THM, Ng VHE, Kwok HS, Lin JS, Qi L, Han J, Tay DJT, Tang SJ, Yang H, Song Y, Bellido Molias F, Tenen DG, Chen L. Nucleic Acids Res. 2018 Sep 6;46(15):7953-7969. doi: 10.1093/nar/gky396. PubMed
PPARgamma is dispensable for clear cell renal cell carcinoma progression. Sanchez DJ, Steger DJ, Skuli N, Bansal A, Simon MC. Mol Metab. 2018 Aug;14:139-149. doi: 10.1016/j.molmet.2018.05.013. Epub 2018 May 21. PubMed
Dishevelled has a YAP nuclear export function in a tumor suppressor context-dependent manner. Lee Y, Kim NH, Cho ES, Yang JH, Cha YH, Kang HE, Yun JS, Cho SB, Lee SH, Paclikova P, Radaszkiewicz TW, Bryja V, Kang CG, Yuk YS, Cha SY, Kim SY, Kim HS, Yook JI. Nat Commun. 2018 Jun 12;9(1):2301. doi: 10.1038/s41467-018-04757-w. PubMed
DDX3 Activates CBC-eIF3-Mediated Translation of uORF-Containing Oncogenic mRNAs to Promote Metastasis in HNSCC. Chen HH, Yu HI, Yang MH, Tarn WY. Cancer Res. 2018 Aug 15;78(16):4512-4523. doi: 10.1158/0008-5472.CAN-18-0282. Epub 2018 Jun 19. PubMed
Human Cytomegalovirus Immediate Early 1 Protein Causes Loss of SOX2 from Neural Progenitor Cells by Trapping Unphosphorylated STAT3 in the Nucleus. Wu CC, Jiang X, Wang XZ, Liu XJ, Li XJ, Yang B, Ye HQ, Harwardt T, Jiang M, Xia HM, Wang W, Britt WJ, Paulus C, Nevels M, Luo MH. J Virol. 2018 Aug 16;92(17). pii: JVI.00340-18. doi: 10.1128/JVI.00340-18. Print 2018 Sep 1. PubMed
Differential effects of GLI2 and GLI3 in regulating cervical cancer malignancy in vitro and in vivo. Zhu H, Xia L, Shen Q, Zhao M, Gu X, Bouamar H, Wang B, Sun LZ, Zhu X. Lab Invest. 2018 Nov;98(11):1384-1396. doi: 10.1038/s41374-018-0089-5. Epub 2018 Jul 2. PubMed Associated Plasmids pTet-GLI2shR pTet-ctl
Oncogenic addiction to high 26S proteasome level. Tsvetkov P, Adler J, Myers N, Biran A, Reuven N, Shaul Y. Cell Death Dis. 2018 Jul 10;9(7):773. doi: 10.1038/s41419-018-0806-4. PubMed
Targeted Enhancer Activation by a Subunit of the Integrator Complex. Barbieri E, Trizzino M, Welsh SA, Owens TA, Calabretta B, Carroll M, Sarma K, Gardini A. Mol Cell. 2018 Jul 5;71(1):103-116.e7. doi: 10.1016/j.molcel.2018.05.031. Epub 2018 Jun 28. PubMed
HUWE1 controls the development of non-small cell lung cancer through down-regulation of p53. Yang D, Cheng D, Tu Q, Yang H, Sun B, Yan L, Dai H, Luo J, Mao B, Cao Y, Yu X, Jiang H, Zhao X. Theranostics. 2018 Jun 6;8(13):3517-3529. doi: 10.7150/thno.24401. eCollection 2018. PubMed
Positive cofactor 4 (PC4) contributes to the regulation of replication-dependent canonical histone gene expression. Brzek A, Cichocka M, Dolata J, Juzwa W, Schumperli D, Raczynska KD. BMC Mol Biol. 2018 Jul 27;19(1):9. doi: 10.1186/s12867-018-0110-y. PubMed
OCT4 directly regulates stemness and extracellular matrix-related genes in human germ cell tumours. Song B, Kim DK, Shin J, Bae SH, Kim HY, Won B, Kim JK, Youn HD, Kim ST, Kang SW, Jang H. Biochem Biophys Res Commun. 2018 Sep 10;503(3):1980-1986. doi: 10.1016/j.bbrc.2018.07.145. Epub 2018 Aug 3. PubMed
Triglycerides Promote Lipid Homeostasis during Hypoxic Stress by Balancing Fatty Acid Saturation. Ackerman D, Tumanov S, Qiu B, Michalopoulou E, Spata M, Azzam A, Xie H, Simon MC, Kamphorst JJ. Cell Rep. 2018 Sep 4;24(10):2596-2605.e5. doi: 10.1016/j.celrep.2018.08.015. PubMed
Targeting LRP8 inhibits breast cancer stem cells in triple-negative breast cancer. Lin CC, Lo MC, Moody R, Jiang H, Harouaka R, Stevers N, Tinsley S, Gasparyan M, Wicha M, Sun D. Cancer Lett. 2018 Dec 1;438:165-173. doi: 10.1016/j.canlet.2018.09.022. Epub 2018 Sep 15. PubMed
Tumor-Stroma Mechanics Coordinate Amino Acid Availability to Sustain Tumor Growth and Malignancy. Bertero T, Oldham WM, Grasset EM, Bourget I, Boulter E, Pisano S, Hofman P, Bellvert F, Meneguzzi G, Bulavin DV, Estrach S, Feral CC, Chan SY, Bozec A, Gaggioli C. Cell Metab. 2019 Jan 8;29(1):124-140.e10. doi: 10.1016/j.cmet.2018.09.012. Epub 2018 Oct 4. PubMed
MYC Interacts with the G9a Histone Methyltransferase to Drive Transcriptional Repression and Tumorigenesis. Tu WB, Shiah YJ, Lourenco C, Mullen PJ, Dingar D, Redel C, Tamachi A, Ba-Alawi W, Aman A, Al-Awar R, Cescon DW, Haibe-Kains B, Arrowsmith CH, Raught B, Boutros PC, Penn LZ. Cancer Cell. 2018 Oct 8;34(4):579-595.e8. doi: 10.1016/j.ccell.2018.09.001. PubMed Associated Plasmids pcDNA3.1 MYC pcDNA3.1 MYC dBR pcDNA3.1 MYC dHLH pcDNA3.1 MYC dLZ pcDNA3.1 His-V5 Myc More ...
Tumor-Derived cGAMP Triggers a STING-Mediated Interferon Response in Non-tumor Cells to Activate the NK Cell Response. Marcus A, Mao AJ, Lensink-Vasan M, Wang L, Vance RE, Raulet DH. Immunity. 2018 Oct 16;49(4):754-763.e4. doi: 10.1016/j.immuni.2018.09.016. PubMed
TRPS1 Is a Lineage-Specific Transcriptional Dependency in Breast Cancer. Witwicki RM, Ekram MB, Qiu X, Janiszewska M, Shu S, Kwon M, Trinh A, Frias E, Ramadan N, Hoffman G, Yu K, Xie Y, McAllister G, McDonald R, Golji J, Schlabach M, deWeck A, Keen N, Chan HM, Ruddy D, Rejtar T, Sovath S, Silver S, Sellers WR, Jagani Z, Hogarty MD, Roberts C, Brown M, Stegmaier K, Long H, Shivdasani RA, Pellman D, Polyak K. Cell Rep. 2018 Oct 30;25(5):1255-1267.e5. doi: 10.1016/j.celrep.2018.10.023. PubMed
Predicting Novel Therapies and Targets: Regulation of Notch3 by the Bromodomain Protein BRD4. Villar-Prados A, Wu SY, Court KA, Ma S, LaFargue C, Chowdhury MA, Engelhardt MI, Ivan C, Ram PT, Wang Y, Baggerly K, Rodriguez-Aguayo C, Lopez-Berestein G, Ming-Yang S, Maloney DJ, Yoshioka M, Strovel JW, Roszik J, Sood AK. Mol Cancer Ther. 2019 Feb;18(2):421-436. doi: 10.1158/1535-7163.MCT-18-0365. Epub 2018 Nov 12. PubMed
Plasminogen Activator Inhibitor-1 Promotes the Recruitment and Polarization of Macrophages in Cancer. Kubala MH, Punj V, Placencio-Hickok VR, Fang H, Fernandez GE, Sposto R, DeClerck YA. Cell Rep. 2018 Nov 20;25(8):2177-2191.e7. doi: 10.1016/j.celrep.2018.10.082. PubMed
Janus Kinase 1 Plays a Critical Role in Mammary Cancer Progression. Wehde BL, Radler PD, Shrestha H, Johnson SJ, Triplett AA, Wagner KU. Cell Rep. 2018 Nov 20;25(8):2192-2207.e5. doi: 10.1016/j.celrep.2018.10.063. PubMed
Inhibitor of Differentiation-1 Sustains Mutant KRAS-Driven Progression, Maintenance, and Metastasis of Lung Adenocarcinoma via Regulation of a FOSL1 Network. Roman M, Lopez I, Guruceaga E, Baraibar I, Ecay M, Collantes M, Nadal E, Vallejo A, Cadenas S, Miguel ME, Jang JH, Martin-Uriz PS, Castro-Labrador L, Vilas-Zornoza A, Lara-Astiaso D, Ponz-Sarvise M, Rolfo C, Santos ES, Raez LE, Taverna S, Behrens C, Weder W, Wistuba II, Vicent S, Gil-Bazo I. Cancer Res. 2019 Feb 1;79(3):625-638. doi: 10.1158/0008-5472.CAN-18-1479. Epub 2018 Dec 18. PubMed
RNA interference screen identifies NAA10 as a regulator of PXR transcription. Oladimeji PO, Wright WC, Wu J, Chen T. Biochem Pharmacol. 2019 Feb;160:92-109. doi: 10.1016/j.bcp.2018.12.012. Epub 2018 Dec 16. PubMed
Anti-Human Rhinovirus 1B Activity of Dexamethasone viaGCR-Dependent Autophagy Activation. Lee JS, Kim SR, Song JH, Lee YP, Ko HJ. Osong Public Health Res Perspect. 2018 Dec;9(6):334-339. doi: 10.24171/j.phrp.2018.9.6.07. PubMed
SHP2 Drives Adaptive Resistance to ERK Signaling Inhibition in Molecularly Defined Subsets of ERK-Dependent Tumors. Ahmed TA, Adamopoulos C, Karoulia Z, Wu X, Sachidanandam R, Aaronson SA, Poulikakos PI. Cell Rep. 2019 Jan 2;26(1):65-78.e5. doi: 10.1016/j.celrep.2018.12.013. PubMed
Functional Genomics Reveals Synthetic Lethality between Phosphogluconate Dehydrogenase and Oxidative Phosphorylation. Sun Y, Bandi M, Lofton T, Smith M, Bristow CA, Carugo A, Rogers N, Leonard P, Chang Q, Mullinax R, Han J, Shi X, Seth S, Meyers BA, Miller M, Miao L, Ma X, Feng N, Giuliani V, Geck Do M, Czako B, Palmer WS, Mseeh F, Asara JM, Jiang Y, Morlacchi P, Zhao S, Peoples M, Tieu TN, Warmoes MO, Lorenzi PL, Muller FL, DePinho RA, Draetta GF, Toniatti C, Jones P, Heffernan TP, Marszalek JR. Cell Rep. 2019 Jan 8;26(2):469-482.e5. doi: 10.1016/j.celrep.2018.12.043. PubMed
BRCA2 deficiency instigates cGAS-mediated inflammatory signaling and confers sensitivity to tumor necrosis factor-alpha-mediated cytotoxicity. Heijink AM, Talens F, Jae LT, van Gijn SE, Fehrmann RSN, Brummelkamp TR, van Vugt MATM. Nat Commun. 2019 Jan 9;10(1):100. doi: 10.1038/s41467-018-07927-y. PubMed
Requirement for PRC1 subunit BMI1 in host gene activation by Epstein-Barr virus protein EBNA3C. Paschos K, Bazot Q, Lees J, Farrell PJ, Allday MJ. Nucleic Acids Res. 2019 Jan 15. pii: 5289486. doi: 10.1093/nar/gky1323. PubMed
Loss of BCAA Catabolism during Carcinogenesis Enhances mTORC1 Activity and Promotes Tumor Development and Progression. Ericksen RE, Lim SL, McDonnell E, Shuen WH, Vadiveloo M, White PJ, Ding Z, Kwok R, Lee P, Radda GK, Toh HC, Hirschey MD, Han W. Cell Metab. 2019 May 7;29(5):1151-1165.e6. doi: 10.1016/j.cmet.2018.12.020. Epub 2019 Jan 17. PubMed
Wild-Type p53 Promotes Cancer Metabolic Switch by Inducing PUMA-Dependent Suppression of Oxidative Phosphorylation. Kim J, Yu L, Chen W, Xu Y, Wu M, Todorova D, Tang Q, Feng B, Jiang L, He J, Chen G, Fu X, Xu Y. Cancer Cell. 2019 Feb 11;35(2):191-203.e8. doi: 10.1016/j.ccell.2018.12.012. Epub 2019 Jan 31. PubMed
De Novo PITX1 Expression Controls Bi-Stable Transcriptional Circuits to Govern Self-Renewal and Differentiation in Squamous Cell Carcinoma. Sastre-Perona A, Hoang-Phou S, Leitner MC, Okuniewska M, Meehan S, Schober M. Cell Stem Cell. 2019 Mar 7;24(3):390-404.e8. doi: 10.1016/j.stem.2019.01.003. Epub 2019 Jan 31. PubMed
Sequence-dependent cross-resistance of combined radiotherapy plus BRAF(V600E) inhibition in melanoma. Shannan B, Matschke J, Chauvistre H, Vogel F, Klein D, Meier F, Westphal D, Bruns J, Rauschenberg R, Utikal J, Forschner A, Berking C, Terheyden P, Dabrowski E, Gutzmer R, Rafei-Shamsabadi D, Meiss F, Heinzerling L, Zimmer L, Livingstone E, Varaljai R, Hoewner A, Horn S, Klode J, Stuschke M, Scheffler B, Marchetto A, Sannino G, Grunewald TGP, Schadendorf D, Jendrossek V, Roesch A. Eur J Cancer. 2019 Mar;109:137-153. doi: 10.1016/j.ejca.2018.12.024. Epub 2019 Feb 2. PubMed
Identification of different gene expressions between diffuse- and intestinal-type spheroid-forming gastric cancer cells. Lee JW, Sung JS, Park YS, Chung S, Kim YH. Gastric Cancer. 2019 Feb 6. pii: 10.1007/s10120-019-00935-x. doi: 10.1007/s10120-019-00935-x. PubMed
Targeting the CALCB/RAMP1 axis inhibits growth of Ewing sarcoma. Dallmayer M, Li J, Ohmura S, Alba Rubio R, Baldauf MC, Holting TLB, Musa J, Knott MML, Stein S, Cidre-Aranaz F, Wehweck FS, Romero-Perez L, Gerke JS, Orth MF, Marchetto A, Kirchner T, Bach H, Sannino G, Grunewald TGP. Cell Death Dis. 2019 Feb 11;10(2):116. doi: 10.1038/s41419-019-1372-0. PubMed
C/EBPbeta Is a Transcriptional Regulator of Wee1 at the G(2)/M Phase of the Cell Cycle. Lee JH, Sung JY, Choi EK, Yoon HK, Kang BR, Hong EK, Park BK, Kim YN, Rho SB, Yoon K. Cells. 2019 Feb 11;8(2). pii: cells8020145. doi: 10.3390/cells8020145. PubMed
The prognostic landscape of interactive biological processes presents treatment responses in cancer. He B, Gao R, Lv D, Wen Y, Song L, Wang X, Lin S, Huang Q, Deng Z, Wang Z, Yan M, Zheng F, Lam EW, Kelley KW, Li Z, Liu Q. EBioMedicine. 2019 Mar;41:120-133. doi: 10.1016/j.ebiom.2019.01.064. Epub 2019 Feb 22. PubMed
NAA40 contributes to colorectal cancer growth by controlling PRMT5 expression. Demetriadou C, Pavlou D, Mpekris F, Achilleos C, Stylianopoulos T, Zaravinos A, Papageorgis P, Kirmizis A. Cell Death Dis. 2019 Mar 11;10(3):236. doi: 10.1038/s41419-019-1487-3. PubMed
The fraction of CD117/c-KIT-expressing erythroid precursors predicts ESA response in low-risk myelodysplastic syndromes. Raimbault A, Itzykson R, Willems L, Rousseau A, Chapuis N, Mathis S, Clauser S, Radford-Weiss I, Bouscary D, Fontenay M, Kosmider O, Bardet V. Cytometry B Clin Cytom. 2019 May;96(3):215-222. doi: 10.1002/cyto.b.21781. Epub 2019 Apr 9. PubMed
The homeobox transcription factor MEIS2 is a regulator of cancer cell survival and IMiDs activity in Multiple Myeloma: modulation by Bromodomain and Extra-Terminal (BET) protein inhibitors. Abruzzese MP, Bilotta MT, Fionda C, Zingoni A, Soriani A, Petrucci MT, Ricciardi MR, Molfetta R, Paolini R, Santoni A, Cippitelli M. Cell Death Dis. 2019 Apr 11;10(4):324. doi: 10.1038/s41419-019-1562-9. PubMed
Genome-wide CRISPR knockout screens identify NCAPG as an essential oncogene for hepatocellular carcinoma tumor growth. Wang Y, Gao B, Tan PY, Handoko YA, Sekar K, Deivasigamani A, Seshachalam VP, OuYang HY, Shi M, Xie C, Goh BKP, Ooi LL, Man Hui K. FASEB J. 2019 Aug;33(8):8759-8770. doi: 10.1096/fj.201802213RR. Epub 2019 Apr 25. PubMed
METTL1 Promotes let-7 MicroRNA Processing via m7G Methylation. Pandolfini L, Barbieri I, Bannister AJ, Hendrick A, Andrews B, Webster N, Murat P, Mach P, Brandi R, Robson SC, Migliori V, Alendar A, d'Onofrio M, Balasubramanian S, Kouzarides T. Mol Cell. 2019 Jun 20;74(6):1278-1290.e9. doi: 10.1016/j.molcel.2019.03.040. Epub 2019 Apr 25. PubMed
Myo1f, an Unconventional Long-Tailed Myosin, Is a New Partner for the Adaptor 3BP2 Involved in Mast Cell Migration. Navines-Ferrer A, Ainsua-Enrich E, Serrano-Candelas E, Sayos J, Martin M. Front Immunol. 2019 May 9;10:1058. doi: 10.3389/fimmu.2019.01058. eCollection 2019. PubMed
BAP1 Loss Is Associated with DNA Methylomic Repatterning in Highly Aggressive Class 2 Uveal Melanomas. Field MG, Kuznetsov JN, Bussies PL, Cai LZ, Alawa KA, Decatur CL, Kurtenbach S, Harbour JW. Clin Cancer Res. 2019 Sep 15;25(18):5663-5673. doi: 10.1158/1078-0432.CCR-19-0366. Epub 2019 Jul 8. PubMed
How to Choose the Right Inducible Gene Expression System for Mammalian Studies? Kallunki T, Barisic M, Jaattela M, Liu B. Cells. 2019 Jul 30;8(8). pii: cells8080796. doi: 10.3390/cells8080796. PubMed
Novel p97/VCP inhibitor induces endoplasmic reticulum stress and apoptosis in both bortezomib-sensitive and -resistant multiple myeloma cells. Nishimura N, Radwan MO, Amano M, Endo S, Fujii E, Hayashi H, Ueno S, Ueno N, Tatetsu H, Hata H, Okamoto Y, Otsuka M, Mitsuya H, Matsuoka M, Okuno Y. Cancer Sci. 2019 Oct;110(10):3275-3287. doi: 10.1111/cas.14154. Epub 2019 Aug 14. PubMed
p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas. Hsieh MH, Choe JH, Gadhvi J, Kim YJ, Arguez MA, Palmer M, Gerold H, Nowak C, Do H, Mazambani S, Knighton JK, Cha M, Goodwin J, Kang MK, Jeong JY, Lee SY, Faubert B, Xuan Z, Abel ED, Scafoglio C, Shackelford DB, Minna JD, Singh PK, Shulaev V, Bleris L, Hoyt K, Kim J, Inoue M, DeBerardinis RJ, Kim TH, Kim JW. Cell Rep. 2019 Aug 13;28(7):1860-1878.e9. doi: 10.1016/j.celrep.2019.07.027. PubMed
FAK-Copy-Gain Is a Predictive Marker for Sensitivity to FAK Inhibition in Breast Cancer. Kim YH, Kim HK, Kim HY, Gawk H, Bae SH, Sim HW, Kang EK, Seoh JY, Jang H, Hong KM. Cancers (Basel). 2019 Sep 2;11(9). pii: cancers11091288. doi: 10.3390/cancers11091288. PubMed Associated Plasmids pLKO.1-Teton-puro-shFAK #1 pLKO.1-Teton-puro-shFAK #2
MUC1-C Activates the NuRD Complex to Drive Dedifferentiation of Triple-Negative Breast Cancer Cells. Hata T, Rajabi H, Takahashi H, Yasumizu Y, Li W, Jin C, Long MD, Hu Q, Liu S, Fushimi A, Yamashita N, Kui L, Hong D, Yamamoto M, Miyo M, Hiraki M, Maeda T, Suzuki Y, Samur MK, Kufe D. Cancer Res. 2019 Nov 15;79(22):5711-5722. doi: 10.1158/0008-5472.CAN-19-1034. Epub 2019 Sep 13. PubMed
ER-lysosome contacts enable cholesterol sensing by mTORC1 and drive aberrant growth signalling in Niemann-Pick type C. Lim CY, Davis OB, Shin HR, Zhang J, Berdan CA, Jiang X, Counihan JL, Ory DS, Nomura DK, Zoncu R. Nat Cell Biol. 2019 Oct;21(10):1206-1218. doi: 10.1038/s41556-019-0391-5. Epub 2019 Sep 23. PubMed Associated Plasmids pGEX-KG-D4H*-mCherry pLJM1-FLAG-GFP-Tmem192 pLJM1-Tmem192-mRFP-3xHA pLJM1-Lyso-FLAG-GFP-Sac1-Cat-WT pLJM1-Lyso-FLAG-GFP-Sac1-Cat-CS More ...
Targeting PML in triple negative breast cancer elicits growth suppression and senescence. Arreal L, Piva M, Fernandez S, Revandkar A, Schaub-Clerigue A, Villanueva J, Zabala-Letona A, Pujana M, Astobiza I, Cortazar AR, Hermanova I, Bozal-Basterra L, Arruabarrena-Aristorena A, Crespo JR, Valcarcel-Jimenez L, Zuniga-Garcia P, Canals F, Torrano V, Barrio R, Sutherland JD, Alimonti A, Martin-Martin N, Carracedo A. Cell Death Differ. 2019 Oct 1. pii: 10.1038/s41418-019-0407-5. doi: 10.1038/s41418-019-0407-5. PubMed
PGC1alpha Suppresses Prostate Cancer Cell Invasion through ERRalpha Transcriptional Control. Valcarcel-Jimenez L, Macchia A, Crosas-Molist E, Schaub-Clerigue A, Camacho L, Martin-Martin N, Cicogna P, Viera-Bardon C, Fernandez-Ruiz S, Rodriguez-Hernandez I, Hermanova I, Astobiza I, Cortazar AR, Corres-Mendizabal J, Gomez-Munoz A, Sanz-Moreno V, Torrano V, Carracedo A. Cancer Res. 2019 Dec 15;79(24):6153-6165. doi: 10.1158/0008-5472.CAN-19-1231. Epub 2019 Oct 8. PubMed
LCP1 triggers mTORC2/AKT activity and is pharmacologically targeted by enzastaurin in hypereosinophilia. Ma G, Gezer D, Herrmann O, Feldberg K, Schemionek M, Jawhar M, Reiter A, Brummendorf TH, Koschmieder S, Chatain N. Mol Carcinog. 2020 Jan;59(1):87-103. doi: 10.1002/mc.23131. Epub 2019 Nov 6. PubMed
The Leukemogenic TCF3-HLF Complex Rewires Enhancers Driving Cellular Identity and Self-Renewal Conferring EP300 Vulnerability. Huang Y, Mouttet B, Warnatz HJ, Risch T, Rietmann F, Frommelt F, Ngo QA, Dobay MP, Marovca B, Jenni S, Tsai YC, Matzk S, Amstislavskiy V, Schrappe M, Stanulla M, Gstaiger M, Bornhauser B, Yaspo ML, Bourquin JP. Cancer Cell. 2019 Dec 9;36(6):630-644.e9. doi: 10.1016/j.ccell.2019.10.004. Epub 2019 Nov 14. PubMed Associated Plasmids pL40C_PGKintron_Cas9_Green FpG5.BFP.Reporter
IL-36gamma drives skin toxicity induced by EGFR/MEK inhibition and commensal Cutibacterium acnes. Satoh TK, Mellett M, Meier-Schiesser B, Fenini G, Otsuka A, Beer HD, Rordorf T, Maul JT, Hafner J, Navarini AA, Contassot E, French LE. J Clin Invest. 2020 Feb 4. pii: 128678. doi: 10.1172/JCI128678. PubMed
Cationic Amino Acid Transporter-1-Mediated Arginine Uptake Is Essential for Chronic Lymphocytic Leukemia Cell Proliferation and Viability. Werner A, Pieh D, Echchannaoui H, Rupp J, Rajalingam K, Theobald M, Closs EI, Munder M. Front Oncol. 2019 Nov 20;9:1268. doi: 10.3389/fonc.2019.01268. eCollection 2019. PubMed
A TAZ-AXL-ABL2 Feed-Forward Signaling Axis Promotes Lung Adenocarcinoma Brain Metastasis. Hoj JP, Mayro B, Pendergast AM. Cell Rep. 2019 Dec 10;29(11):3421-3434.e8. doi: 10.1016/j.celrep.2019.11.018. PubMed
NAMPT Inhibition Suppresses Cancer Stem-like Cells Associated with Therapy-Induced Senescence in Ovarian Cancer. Nacarelli T, Fukumoto T, Zundell JA, Fatkhutdinov N, Jean S, Cadungog MG, Borowsky ME, Zhang R. Cancer Res. 2020 Feb 15;80(4):890-900. doi: 10.1158/0008-5472.CAN-19-2830. Epub 2019 Dec 19. PubMed
Contribution of synergism between PHF8 and HER2 signalling to breast cancer development and drug resistance. Liu Q, Borcherding NC, Shao P, Maina PK, Zhang W, Qi HH. EBioMedicine. 2020 Jan;51:102612. doi: 10.1016/j.ebiom.2019.102612. Epub 2020 Jan 7. PubMed
Reprogramming fatty acyl specificity of lipid kinases via C1 domain engineering. Ware TB, Franks CE, Granade ME, Zhang M, Kim KB, Park KS, Gahlmann A, Harris TE, Hsu KL. Nat Chem Biol. 2020 Feb;16(2):170-178. doi: 10.1038/s41589-019-0445-9. Epub 2020 Jan 13. PubMed
Epigenetic Silencing of CDR1as Drives IGF2BP3-Mediated Melanoma Invasion and Metastasis. Hanniford D, Ulloa-Morales A, Karz A, Berzoti-Coelho MG, Moubarak RS, Sanchez-Sendra B, Kloetgen A, Davalos V, Imig J, Wu P, Vasudevaraja V, Argibay D, Lilja K, Tabaglio T, Monteagudo C, Guccione E, Tsirigos A, Osman I, Aifantis I, Hernando E. Cancer Cell. 2020 Jan 13;37(1):55-70.e15. doi: 10.1016/j.ccell.2019.12.007. PubMed
MUC1-C regulates lineage plasticity driving progression to neuroendocrine prostate cancer. Yasumizu Y, Rajabi H, Jin C, Hata T, Pitroda S, Long MD, Hagiwara M, Li W, Hu Q, Liu S, Yamashita N, Fushimi A, Kui L, Samur M, Yamamoto M, Zhang Y, Zhang N, Hong D, Maeda T, Kosaka T, Wong KK, Oya M, Kufe D. Nat Commun. 2020 Jan 17;11(1):338. doi: 10.1038/s41467-019-14219-6. PubMed
Stress-induced lncRNA LASTR fosters cancer cell fitness by regulating the activity of the U4/U6 recycling factor SART3. De Troyer L, Zhao P, Pastor T, Baietti MF, Barra J, Vendramin R, Dok R, Lechat B, Najm P, Van Haver D, Impens F, Leucci E, Sablina AA. Nucleic Acids Res. 2020 Mar 18;48(5):2502-2517. doi: 10.1093/nar/gkz1237. PubMed
Prostaglandin E2 and its receptor EP2 trigger signaling that contributes to YAP-mediated cell competition. Ishihara E, Nagaoka Y, Okuno T, Kofuji S, Ishigami-Yuasa M, Kagechika H, Kamimura K, Terai S, Yokomizo T, Sugimoto Y, Fujita Y, Suzuki A, Nishina H. Genes Cells. 2020 Mar;25(3):197-214. doi: 10.1111/gtc.12750. Epub 2020 Feb 7. PubMed
MTR4 drives liver tumorigenesis by promoting cancer metabolic switch through alternative splicing. Yu L, Kim J, Jiang L, Feng B, Ying Y, Ji KY, Tang Q, Chen W, Mai T, Dou W, Zhou J, Xiang LY, He YF, Yang D, Li Q, Fu X, Xu Y. Nat Commun. 2020 Feb 5;11(1):708. doi: 10.1038/s41467-020-14437-3. PubMed
Synergistic lethality between PARP-trapping and alantolactone-induced oxidative DNA damage in homologous recombination-proficient cancer cells. Wang H, Zhang S, Song L, Qu M, Zou Z. Oncogene. 2020 Apr;39(14):2905-2920. doi: 10.1038/s41388-020-1191-x. Epub 2020 Feb 6. PubMed
Topoisomerase 1 cleavage complex enables pattern recognition and inflammation during senescence. Zhao B, Liu P, Fukumoto T, Nacarelli T, Fatkhutdinov N, Wu S, Lin J, Aird KM, Tang HY, Liu Q, Speicher DW, Zhang R. Nat Commun. 2020 Feb 19;11(1):908. doi: 10.1038/s41467-020-14652-y. PubMed
Association of BRCA Mutations and BRCAness Status With Anticancer Drug Sensitivities in Triple-Negative Breast Cancer Cell Lines Teraoka S, Muguruma M, Takano N, Miyahara K, Kawate T, Kaise H, Yamada K, Miyazawa K, Ishikawa T. J Surg Res. 2020 Jun;250:200-208. doi: 10.1016/j.jss.2019.12.040. Epub 2020 Feb 21. PubMed
MYC Regulation of D2HGDH and L2HGDH Influences the Epigenome and Epitranscriptome. Qiu Z, Lin AP, Jiang S, Elkashef SM, Myers J, Srikantan S, Sasi B, Cao JZ, Godley LA, Rakheja D, Lyu Y, Zheng S, Madesh M, Shiio Y, Dahia PLM, Aguiar RCT. Cell Chem Biol. 2020 May 21;27(5):538-550.e7. doi: 10.1016/j.chembiol.2020.02.002. Epub 2020 Feb 25. PubMed
KDM6A-Mediated Expression of the Long Noncoding RNA DINO Causes TP53 Tumor Suppressor Stabilization in Human Papillomavirus 16 E7-Expressing Cells. Sharma S, Munger K. J Virol. 2020 Jun 1;94(12). pii: JVI.02178-19. doi: 10.1128/JVI.02178-19. Print 2020 Jun 1. PubMed
Gli2 mediates the development of castrationresistant prostate cancer. Xia L, Bouamar H, Gu X, Zeballos C, Qin T, Wang B, Zhou Y, Wang Y, Yang J, Zhu H, Zhang W, Houghton PJ, Sun LZ. Int J Oncol. 2020 Jul;57(1):100-112. doi: 10.3892/ijo.2020.5044. Epub 2020 Apr 13. PubMed
Role for the shelterin protein TRF2 in human herpesvirus 6A/B chromosomal integration. Gilbert-Girard S, Gravel A, Collin V, Wight DJ, Kaufer BB, Lazzerini-Denchi E, Flamand L. PLoS Pathog. 2020 Apr 22;16(4):e1008496. doi: 10.1371/journal.ppat.1008496. eCollection 2020 Apr. PubMed
Lineage-Specific Epigenomic and Genomic Activation of Oncogene HNF4A Promotes Gastrointestinal Adenocarcinomas. Pan J, Silva TC, Gull N, Yang Q, Plummer JT, Chen S, Daigo K, Hamakubo T, Gery S, Ding LW, Jiang YY, Hu S, Xu LY, Li EM, Ding Y, Klempner SJ, Gayther SA, Berman BP, Koeffler HP, Lin DC. Cancer Res. 2020 Jul 1;80(13):2722-2736. doi: 10.1158/0008-5472.CAN-20-0390. Epub 2020 Apr 24. PubMed
Regulation of mRNA export through API5 and nuclear FGF2 interaction. Bong SM, Bae SH, Song B, Gwak H, Yang SW, Kim S, Nam S, Rajalingam K, Oh SJ, Kim TW, Park S, Jang H, Lee BI. Nucleic Acids Res. 2020 Jun 19;48(11):6340-6352. doi: 10.1093/nar/gkaa335. PubMed Associated Plasmids pET28b-API5 pHis-LMW_FGF2 pGEX-API5 pGEX-UAP56 pCAG-F-API5 More ...
Melatonin restores the pluripotency of long-term-cultured embryonic stem cells through melatonin receptor-dependent m6A RNA regulation. Yang L, Liu X, Song L, Su G, Di A, Bai C, Wei Z, Li G. J Pineal Res. 2020 Sep;69(2):e12669. doi: 10.1111/jpi.12669. Epub 2020 May 27. PubMed
MUC1-C drives stemness in progression of colitis to colorectal cancer. Li W, Zhang N, Jin C, Long MD, Rajabi H, Yasumizu Y, Fushimi A, Yamashita N, Hagiwara M, Zheng R, Wang J, Kui L, Singh H, Kharbanda S, Hu Q, Liu S, Kufe D. JCI Insight. 2020 Jun 18;5(12). pii: 137112. doi: 10.1172/jci.insight.137112. PubMed
Snail augments fatty acid oxidation by suppression of mitochondrial ACC2 during cancer progression. Yang JH, Kim NH, Yun JS, Cho ES, Cha YH, Cho SB, Lee SH, Cha SY, Kim SY, Choi J, Nguyen TM, Park S, Kim HS, Yook JI. Life Sci Alliance. 2020 Jun 2;3(7). pii: 3/7/e202000683. doi: 10.26508/lsa.202000683. Print 2020 Jul. PubMed
Metabolic Fingerprinting Links Oncogenic PIK3CA with Enhanced Arachidonic Acid-Derived Eicosanoids. Koundouros N, Karali E, Tripp A, Valle A, Inglese P, Perry NJS, Magee DJ, Anjomani Virmouni S, Elder GA, Tyson AL, Doria ML, van Weverwijk A, Soares RF, Isacke CM, Nicholson JK, Glen RC, Takats Z, Poulogiannis G. Cell. 2020 Jun 25;181(7):1596-1611.e27. doi: 10.1016/j.cell.2020.05.053. Epub 2020 Jun 18. PubMed
Autophagy inhibition impairs the invasion potential of medulloblastoma cells. Paul R, Bharambe H, Shirsat NV. Mol Biol Rep. 2020 Jul;47(7):5673-5680. doi: 10.1007/s11033-020-05603-3. Epub 2020 Jul 3. PubMed
Effects of PYRIN-containing Apaf1-like protein 1 on isoflurane-induced postoperative cognitive dysfunction in aged rats. Zhang X, Fan X, Li F, Qiu J, Zhang Y. Mol Med Rep. 2020 Aug;22(2):1391-1399. doi: 10.3892/mmr.2020.11244. Epub 2020 Jun 16. PubMed
Inflammatory IFIT3 renders chemotherapy resistance by regulating post-translational modification of VDAC2 in pancreatic cancer. Wang Z, Qin J, Zhao J, Li J, Li D, Popp M, Popp F, Alakus H, Kong B, Dong Q, Nelson PJ, Zhao Y, Bruns CJ. Theranostics. 2020 Jun 1;10(16):7178-7192. doi: 10.7150/thno.43093. eCollection 2020. PubMed
CHD4 promotes breast cancer progression as a coactivator of hypoxia-inducible factors. Wang Y, Chen Y, Bao L, Zhang B, Wang JE, Kumar A, Xing C, Wang Y, Luo W. Cancer Res. 2020 Jul 22. pii: 0008-5472.CAN-20-1049. doi: 10.1158/0008-5472.CAN-20-1049. PubMed
Combination Treatment with GSK126 and Pomalidomide Induces B-Cell Differentiation in EZH2 Gain-of-Function Mutant Diffuse Large B-Cell Lymphoma. Park S, Jo SH, Kim JH, Kim SY, Ha JD, Hwang JY, Lee MY, Kang JS, Han TS, Park SG, Kim S, Park BC, Kim JH. Cancers (Basel). 2020 Sep 7;12(9). pii: cancers12092541. doi: 10.3390/cancers12092541. PubMed
Genomic and Functional Regulation of TRIB1 Contributes to Prostate Cancer Pathogenesis. Shahrouzi P, Astobiza I, Cortazar AR, Torrano V, Macchia A, Flores JM, Niespolo C, Mendizabal I, Caloto R, Ercilla A, Camacho L, Arreal L, Bizkarguenaga M, Martinez-Chantar ML, Bustelo XR, Berra E, Kiss-Toth E, Velasco G, Zabala-Letona A, Carracedo A. Cancers (Basel). 2020 Sep 11;12(9). pii: cancers12092593. doi: 10.3390/cancers12092593. PubMed
FGFR1 Is Critical for RBL2 Loss-Driven Tumor Development and Requires PLCG1 Activation for Continued Growth of Small Cell Lung Cancer. Kim KB, Kim Y, Rivard CJ, Kim DW, Park KS. Cancer Res. 2020 Nov 15;80(22):5051-5062. doi: 10.1158/0008-5472.CAN-20-1453. Epub 2020 Sep 24. PubMed
Metabolic Imaging Detects Resistance to PI3Kalpha Inhibition Mediated by Persistent FOXM1 Expression in ER(+) Breast Cancer. Ros S, Wright AJ, D'Santos P, Hu DE, Hesketh RL, Lubling Y, Georgopoulou D, Lerda G, Couturier DL, Razavi P, Pelossof R, Batra AS, Mannion E, Lewis DY, Martin A, Baird RD, Oliveira M, de Boo LW, Linn SC, Scaltriti M, Rueda OM, Bruna A, Caldas C, Brindle KM. Cancer Cell. 2020 Oct 12;38(4):516-533.e9. doi: 10.1016/j.ccell.2020.08.016. Epub 2020 Sep 24. PubMed
Overexpression of Cyclin E1 or Cdc25A leads to replication stress, mitotic aberrancies, and increased sensitivity to replication checkpoint inhibitors. Kok YP, Guerrero Llobet S, Schoonen PM, Everts M, Bhattacharya A, Fehrmann RSN, van den Tempel N, van Vugt MATM. Oncogenesis. 2020 Oct 7;9(10):88. doi: 10.1038/s41389-020-00270-2. PubMed
Dual Screen for Efficacy and Toxicity Identifies HDAC Inhibitor with Distinctive Activity Spectrum for BAP1-Mutant Uveal Melanoma. Kuznetsoff JN, Owens DA, Lopez A, Rodriguez DA, Chee NT, Kurtenbach S, Bilbao D, Roberts ER, Volmar CH, Wahlestedt C, Brothers SP, Harbour JW. Mol Cancer Res. 2021 Feb;19(2):215-222. doi: 10.1158/1541-7786.MCR-20-0434. Epub 2020 Oct 19. PubMed
PLCgamma1 suppression promotes the adaptation of KRAS-mutant lung adenocarcinomas to hypoxia. Saliakoura M, Rossi Sebastiano M, Pozzato C, Heidel FH, Schnoder TM, Savic Prince S, Bubendorf L, Pinton P, A Schmid R, Baumgartner J, Freigang S, Berezowska SA, Rimessi A, Konstantinidou G. Nat Cell Biol. 2020 Nov;22(11):1382-1395. doi: 10.1038/s41556-020-00592-8. Epub 2020 Oct 19. PubMed
Id1 and PD-1 Combined Blockade Impairs Tumor Growth and Survival of KRAS-mutant Lung Cancer by Stimulating PD-L1 Expression and Tumor Infiltrating CD8(+) T Cells. Baraibar I, Roman M, Rodriguez-Remirez M, Lopez I, Vilalta A, Guruceaga E, Ecay M, Collantes M, Lozano T, Alignani D, Puyalto A, Oliver A, Ortiz-Espinosa S, Moreno H, Torregrosa M, Rolfo C, Caglevic C, Garcia-Ros D, Villalba-Esparza M, De Andrea C, Vicent S, Pio R, Lasarte JJ, Calvo A, Ajona D, Gil-Bazo I. Cancers (Basel). 2020 Oct 28;12(11). pii: cancers12113169. doi: 10.3390/cancers12113169. PubMed
Hyperactive CDK2 Activity in Basal-like Breast Cancer Imposes a Genome Integrity Liability that Can Be Exploited by Targeting DNA Polymerase epsilon. Sviderskiy VO, Blumenberg L, Gorodetsky E, Karakousi TR, Hirsh N, Alvarez SW, Terzi EM, Kaparos E, Whiten GC, Ssebyala S, Tonzi P, Mir H, Neel BG, Huang TT, Adams S, Ruggles KV, Possemato R. Mol Cell. 2020 Oct 28. pii: S1097-2765(20)30723-1. doi: 10.1016/j.molcel.2020.10.016. PubMed Associated Plasmids pLKO.1P POLE1_1 pLKO.1B POLE1_1 pLKO.1P POLE1_2 pLKO.1B POLE1_2 pLKO.1P POLE2 More ...
Stabilization of ERK-Phosphorylated METTL3 by USP5 Increases m(6)A Methylation. Sun HL, Zhu AC, Gao Y, Terajima H, Fei Q, Liu S, Zhang L, Zhang Z, Harada BT, He YY, Bissonnette MB, Hung MC, He C. Mol Cell. 2020 Nov 19;80(4):633-647.e7. doi: 10.1016/j.molcel.2020.10.026. PubMed
Identification of the novel Np17 oncogene in human leukemia. Wu B, Gan Y, Xu Y, Wu Z, Xu G, Wang P, Wang C, Meng Z, Li M, Zhang J, Zhuang H, Zhang X, Yang L, Li J, Gan X, Yu X, Huang W, Gu Y, Xu R. Aging (Albany NY). 2020 Nov 21;12(23):23647-23667. doi: 10.18632/aging.103808. Epub 2020 Nov 21. PubMed
Combinatorial Efficacy of Olaparib with Radiation and ATR Inhibitor Requires PARP1 Protein in Homologous Recombination-Proficient Pancreatic Cancer. Parsels LA, Engelke CG, Parsels J, Flanagan SA, Zhang Q, Tanska D, Wahl DR, Canman CE, Lawrence TS, Morgan MA. Mol Cancer Ther. 2021 Feb;20(2):263-273. doi: 10.1158/1535-7163.MCT-20-0365. Epub 2020 Dec 2. PubMed
Growth of pancreatic cancers with hemizygous chromosomal 17p loss of MYBBP1A can be preferentially targeted by PARP inhibitors. Hsieh A, Pitarresi JR, Lerner J, Donahue G, Hsiehchen D, Rustgi AK, Zaret K. Sci Adv. 2020 Dec 4;6(49). pii: 6/49/eabc4517. doi: 10.1126/sciadv.abc4517. Print 2020 Dec. PubMed
MUC1-C Activates the BAF (mSWI/SNF) Complex in Prostate Cancer Stem Cells. Hagiwara M, Yasumizu Y, Yamashita N, Rajabi H, Fushimi A, Long MD, Li W, Bhattacharya A, Ahmad R, Oya M, Liu S, Kufe D. Cancer Res. 2021 Feb 15;81(4):1111-1122. doi: 10.1158/0008-5472.CAN-20-2588. Epub 2020 Dec 15. PubMed
BRD9 Is a Critical Regulator of Androgen Receptor Signaling and Prostate Cancer Progression. Alpsoy A, Utturkar SM, Carter BC, Dhiman A, Torregrosa-Allen SE, Currie MP, Elzey BD, Dykhuizen EC. Cancer Res. 2021 Feb 15;81(4):820-833. doi: 10.1158/0008-5472.CAN-20-1417. Epub 2020 Dec 21. PubMed
BTF3 confers oncogenic activity in prostate cancer through transcriptional upregulation of Replication Factor C. Zhang Y, Gao X, Yi J, Sang X, Dai Z, Tao Z, Wang M, Shen L, Jia Y, Xie D, Cheng H, Liu Z, Liu P. Cell Death Dis. 2021 Jan 5;12(1):12. doi: 10.1038/s41419-020-03348-2. PubMed
Adrenomedullin-CALCRL axis controls relapse-initiating drug tolerant acute myeloid leukemia cells. Larrue C, Guiraud N, Mouchel PL, Dubois M, Farge T, Gotanegre M, Bosc C, Saland E, Nicolau-Travers ML, Sabatier M, Serhan N, Sahal A, Boet E, Mouche S, Heydt Q, Aroua N, Stuani L, Kaoma T, Angenendt L, Mikesch JH, Schliemann C, Vergez F, Tamburini J, Recher C, Sarry JE. Nat Commun. 2021 Jan 18;12(1):422. doi: 10.1038/s41467-020-20717-9. PubMed
MUC1-C integrates activation of the IFN-gamma pathway with suppression of the tumor immune microenvironment in triple-negative breast cancer. Yamashita N, Long M, Fushimi A, Yamamoto M, Hata T, Hagiwara M, Bhattacharya A, Hu Q, Wong KK, Liu S, Kufe D. J Immunother Cancer. 2021 Jan;9(1). pii: jitc-2020-002115. doi: 10.1136/jitc-2020-002115. PubMed
CAGE-seq reveals that HIV-1 latent infection does not trigger unique cellular responses in a Jurkat T cell model. Matsui H, Shirakawa K, Konishi Y, Hirabayashi S, Sarca AD, Fukuda H, Nomura R, Stanford E, Horisawa Y, Kazuma Y, Matsumoto T, Yamazaki H, Murakawa Y, Battivelli E, Verdin E, Koyanagi Y, Takaori-Kondo A. J Virol. 2021 Jan 27. pii: JVI.02394-20. doi: 10.1128/JVI.02394-20. PubMed
The DNA-helicase HELLS drives ALK(-) ALCL proliferation by the transcriptional control of a cytokinesis-related program. Tameni A, Sauta E, Mularoni V, Torricelli F, Manzotti G, Inghirami G, Bellazzi R, Fragliasso V, Ciarrocchi A. Cell Death Dis. 2021 Jan 27;12(1):130. doi: 10.1038/s41419-021-03425-0. PubMed
RNF168 regulates R-loop resolution and genomic stability in BRCA1/2-deficient tumors. Patel PS, Abraham KJ, Guturi KKN, Halaby MJ, Khan Z, Palomero L, Ho B, Duan S, St-Germain J, Algouneh A, Mateo F, El Ghamrasni S, Barbour H, Barnes DR, Beesley J, Sanchez O, Berman HK, Brown GW, Affar EB, Chenevix-Trench G, Antoniou AC, Arrowsmith CH, Raught B, Pujana MA, Mekhail K, Hakem A, Hakem R. J Clin Invest. 2021 Feb 1;131(3). pii: 140105. doi: 10.1172/JCI140105. PubMed
Data-Driven Computational Modeling Identifies Determinants of Glioblastoma Response to SHP2 Inhibition. Day EK, Zhong Q, Purow B, Lazzara MJ. Cancer Res. 2021 Apr 15;81(8):2056-2070. doi: 10.1158/0008-5472.CAN-20-1756. Epub 2021 Feb 11. PubMed
Distinct genetic pathways define pre-malignant versus compensatory clonal hematopoiesis in Shwachman-Diamond syndrome. Kennedy AL, Myers KC, Bowman J, Gibson CJ, Camarda ND, Furutani E, Muscato GM, Klein RH, Ballotti K, Liu S, Harris CE, Galvin A, Malsch M, Dale D, Gansner JM, Nakano TA, Bertuch A, Vlachos A, Lipton JM, Castillo P, Connelly J, Churpek J, Edwards JR, Hijiya N, Ho RH, Hofmann I, Huang JN, Keel S, Lamble A, Lau BW, Norkin M, Stieglitz E, Stock W, Walkovich K, Boettcher S, Brendel C, Fleming MD, Davies SM, Weller EA, Bahl C, Carter SL, Shimamura A, Lindsley RC. Nat Commun. 2021 Feb 26;12(1):1334. doi: 10.1038/s41467-021-21588-4. PubMed
Disabling VEGF-Response of Purkinje Cells by Downregulation of KDR via miRNA-204-5p. Gehmeyr J, Maghnouj A, Tjaden J, Vorgerd M, Hahn S, Matschke V, Theis V, Theiss C. Int J Mol Sci. 2021 Feb 22;22(4). pii: ijms22042173. doi: 10.3390/ijms22042173. PubMed
ORMDL3 Functions as a Negative Regulator of Antigen-Mediated Mast Cell Activation via an ATF6-UPR-Autophagy-Dependent Pathway. Li J, Ullah MA, Jin H, Liang Y, Lin L, Wang J, Peng X, Liao H, Li Y, Ge Y, Li L. Front Immunol. 2021 Feb 19;12:604974. doi: 10.3389/fimmu.2021.604974. eCollection 2021. PubMed
RAF-Mutant Melanomas Differentially Depend on ERK2 Over ERK1 to Support Aberrant MAPK Pathway Activation and Cell Proliferation. Crowe MS, Zavorotinskaya T, Voliva CF, Shirley MD, Wang Y, Ruddy DA, Rakiec DP, Engelman JA, Stuart DD, Freeman AK. Mol Cancer Res. 2021 Jun;19(6):1063-1075. doi: 10.1158/1541-7786.MCR-20-1022. Epub 2021 Mar 11. PubMed
Pontin Functions as A Transcriptional Co-activator for Retinoic Acid-induced HOX Gene Expression. Tang D, Zhang Z, Zboril E, Wetzel MD, Xu X, Zhang W, Chen L, Liu Z. J Mol Biol. 2021 Jul 9;433(14):166928. doi: 10.1016/j.jmb.2021.166928. Epub 2021 Mar 11. PubMed
Musashi-2 (MSI2) regulates epidermal growth factor receptor (EGFR) expression and response to EGFR inhibitors in EGFR-mutated non-small cell lung cancer (NSCLC). Makhov P, Bychkov I, Faezov B, Deneka A, Kudinov A, Nicolas E, Brebion R, Avril E, Cai KQ, Kharin LV, Voloshin M, Frantsiyants E, Karnaukhov N, Kit OI, Topchu I, Fazliyeva R, Nikonova AS, Serebriiskii IG, Borghaei H, Edelman M, Dulaimi E, Golemis EA, Boumber Y. Oncogenesis. 2021 Mar 15;10(3):29. doi: 10.1038/s41389-021-00317-y. PubMed
Tumor-specific overexpression of histone gene, H3C14 in gastric cancer is mediated through EGFR-FOXC1 axis. Rashid M, Shah SG, Verma T, Chaudhary N, Rauniyar S, Patel VB, Gera PB, Smoot D, Ashaktorab H, Dalal SN, Gupta S. Biochim Biophys Acta Gene Regul Mech. 2021 Apr-May;1864(4-5):194703. doi: 10.1016/j.bbagrm.2021.194703. Epub 2021 Mar 13. PubMed
Loss of BRMS2 induces cell growth inhibition and translation capacity reduction in colorectal cancer cells. Liu Y, Xu W, Xu X, Tan Z, Xu J, Ma L, Du P, Yang Y. Am J Cancer Res. 2021 Mar 1;11(3):930-944. eCollection 2021. PubMed
Loss-of-Function Genetic Screening Identifies Aldolase A as an Essential Driver for Liver Cancer Cell Growth Under Hypoxia. Niu Y, Lin Z, Wan A, Sun L, Yan S, Liang H, Zhan S, Chen D, Bu X, Liu P, Chen C, He W, Lu X, Wan G. Hepatology. 2021 Sep;74(3):1461-1479. doi: 10.1002/hep.31846. PubMed
Autophagy of the m(6)A mRNA demethylase FTO is impaired by low-level arsenic exposure to promote tumorigenesis. Cui YH, Yang S, Wei J, Shea CR, Zhong W, Wang F, Shah P, Kibriya MG, Cui X, Ahsan H, He C, He YY. Nat Commun. 2021 Apr 12;12(1):2183. doi: 10.1038/s41467-021-22469-6. PubMed
Seed-mediated RNA interference of androgen signaling and survival networks induces cell death in prostate cancer cells. Corbin JM, Georgescu C, Wren JD, Xu C, Asch AS, Ruiz-Echevarria MJ. Mol Ther Nucleic Acids. 2021 Mar 5;24:337-351. doi: 10.1016/j.omtn.2021.03.002. eCollection 2021 Jun 4. PubMed
Defining super-enhancer landscape in triple-negative breast cancer by multiomic profiling. Huang H, Hu J, Maryam A, Huang Q, Zhang Y, Ramakrishnan S, Li J, Ma H, Ma VWS, Cheuk W, So GYK, Wang W, Cho WCS, Zhang L, Chan KM, Wang X, Chin YR. Nat Commun. 2021 Apr 14;12(1):2242. doi: 10.1038/s41467-021-22445-0. PubMed
Cross-Species Genomics Reveals Oncogenic Dependencies in ZFTA/C11orf95 Fusion-Positive Supratentorial Ependymomas. Zheng T, Ghasemi DR, Okonechnikov K, Korshunov A, Sill M, Maass KK, Benites Goncalves da Silva P, Ryzhova M, Gojo J, Stichel D, Arabzade A, Kupp R, Benzel J, Taya S, Adachi T, Shiraishi R, Gerber NU, Sturm D, Ecker J, Sievers P, Selt F, Chapman R, Haberler C, Figarella-Branger D, Reifenberger G, Fleischhack G, Rutkowski S, Donson AM, Ramaswamy V, Capper D, Ellison DW, Herold-Mende CC, Schuller U, Brandner S, Driever PH, Kros JM, Snuderl M, Milde T, Grundy RG, Hoshino M, Mack SC, Gilbertson RJ, Jones DTW, Kool M, von Deimling A, Pfister SM, Sahm F, Kawauchi D, Pajtler KW. Cancer Discov. 2021 Sep;11(9):2230-2247. doi: 10.1158/2159-8290.CD-20-0963. Epub 2021 Apr 20. PubMed
FOSL1 promotes cholangiocarcinoma via transcriptional effectors that could be therapeutically targeted. Vallejo A, Erice O, Entrialgo-Cadierno R, Feliu I, Guruceaga E, Perugorria MJ, Olaizola P, Muggli A, Macaya I, O'Dell M, Ruiz-Fernandez de Cordoba B, Ortiz-Espinosa S, Hezel AF, Arozarena I, Lecanda F, Avila MA, Fernandez-Barrena MG, Evert M, Ponz-Sarvise M, Calvisi DF, Banales JM, Vicent S. J Hepatol. 2021 Aug;75(2):363-376. doi: 10.1016/j.jhep.2021.03.028. Epub 2021 Apr 20. PubMed
BRCA1 degradation in response to mitochondrial damage in breast cancer cells. Miyahara K, Takano N, Yamada Y, Kazama H, Tokuhisa M, Hino H, Fujita K, Barroga E, Hiramoto M, Handa H, Kuroda M, Ishikawa T, Miyazawa K. Sci Rep. 2021 Apr 22;11(1):8735. doi: 10.1038/s41598-021-87698-7. PubMed
Reg4 regulates pancreatic regeneration following pancreatitis via modulating the Notch signaling. Dai J, He Y, Jiang M, Niu M, Li B, Wu Z, Bao J, Wen L, Wang X, Hu G. J Cell Physiol. 2021 Apr 26. doi: 10.1002/jcp.30397. PubMed
Cut-like homeobox 1 (CUX1) tumor suppressor gene haploinsufficiency induces apoptosis evasion to sustain myeloid leukemia. Supper E, Rudat S, Iyer V, Droop A, Wong K, Spinella JF, Thomas P, Sauvageau G, Adams DJ, Wong CC. Nat Commun. 2021 Apr 30;12(1):2482. doi: 10.1038/s41467-021-22750-8. PubMed
MYO1F Regulates IgE and MRGPRX2-Dependent Mast Cell Exocytosis. Navines-Ferrer A, Ainsua-Enrich E, Serrano-Candelas E, Proano-Perez E, Munoz-Cano R, Gastaminza G, Olivera A, Martin M. J Immunol. 2021 May 15;206(10):2277-2289. doi: 10.4049/jimmunol.2001211. Epub 2021 May 3. PubMed
Downregulation of ARID1B, a tumor suppressor in the WNT subgroup medulloblastoma, activates multiple oncogenic signaling pathways. Deogharkar A, Singh SV, Bharambe HS, Paul R, Moiyadi A, Goel A, Shetty P, Sridhar E, Gupta T, Jalali R, Goel N, Gadewal N, Muthukumar S, Shirsat NV. Hum Mol Genet. 2021 Aug 28;30(18):1721-1733. doi: 10.1093/hmg/ddab134. PubMed
Depletion of kinesin motor KIF20A to target cell fate control suppresses medulloblastoma tumour growth. Qiu R, Wu J, Gudenas B, Northcott PA, Wechsler-Reya RJ, Lu Q. Commun Biol. 2021 May 11;4(1):552. doi: 10.1038/s42003-021-02075-4. PubMed
Virus-mediated inactivation of anti-apoptotic Bcl-2 family members promotes Gasdermin-E-dependent pyroptosis in barrier epithelial cells. Orzalli MH, Prochera A, Payne L, Smith A, Garlick JA, Kagan JC. Immunity. 2021 Jul 13;54(7):1447-1462.e5. doi: 10.1016/j.immuni.2021.04.012. Epub 2021 May 11. PubMed
Mitofusin-2 stabilizes adherens junctions and suppresses endothelial inflammation via modulation of beta-catenin signaling. Kim YM, Krantz S, Jambusaria A, Toth PT, Moon HG, Gunarathna I, Park GY, Rehman J. Nat Commun. 2021 May 12;12(1):2736. doi: 10.1038/s41467-021-23047-6. PubMed
The extracellular-regulated protein kinase 5 (ERK5) enhances metastatic burden in triple-negative breast cancer through focal adhesion protein kinase (FAK)-mediated regulation of cell adhesion. Xu Q, Zhang J, Telfer BA, Zhang H, Ali N, Chen F, Risa B, Pearson AJ, Zhang W, Finegan KG, Ucar A, Giurisato E, Tournier C. Oncogene. 2021 Jun;40(23):3929-3941. doi: 10.1038/s41388-021-01798-2. Epub 2021 May 12. PubMed
LncRNA CD27-AS1 promotes acute myeloid leukemia progression through the miR-224-5p/PBX3 signaling circuit. Tao Y, Zhang J, Chen L, Liu X, Yao M, Zhang H. Cell Death Dis. 2021 May 18;12(6):510. doi: 10.1038/s41419-021-03767-9. PubMed
Phenotypic plasticity underlies local invasion and distant metastasis in colon cancer. Sacchetti A, Teeuwssen M, Verhagen M, Joosten R, Xu T, Stabile R, van der Steen B, Watson MM, Gusinac A, Kim WK, Ubink I, Van de Werken HJ, Fumagalli A, Paauwe M, Van Rheenen J, Sansom OJ, Kranenburg O, Fodde R. Elife. 2021 May 26;10. pii: 61461. doi: 10.7554/eLife.61461. PubMed
Mapping of m6A and Its Regulatory Targets in Prostate Cancer Reveals a METTL3-low Induction of Therapy Resistance. Cotter KA, Gallon J, Uebersax N, Rubin P, Meyer KD, Piscuoglio S, Jaffrey SR, Rubin MA. Mol Cancer Res. 2021 Jun 4. pii: 1541-7786.MCR-21-0014. doi: 10.1158/1541-7786.MCR-21-0014. PubMed Associated Plasmids METTL3 shRNA 2 tet pLKO puro METTL3 shRNA 1 tet pLKO puro GFP shRNA tet pLKO puro
Colorectal cancer cells utilize autophagy to maintain mitochondrial metabolism for cell proliferation under nutrient stress. Devenport SN, Singhal R, Radyk MD, Taranto JG, Kerk SA, Chen B, Goyert JW, Jain C, Das NK, Oravecz-Wilson K, Zhang L, Greenson JK, Chen YE, Soleimanpour SA, Reddy P, Lyssiotis CA, Shah YM. JCI Insight. 2021 Jun 17;6(14). pii: e138835. doi: 10.1172/jci.insight.138835. PubMed
MUC1-C activates the PBAF chromatin remodeling complex in integrating redox balance with progression of human prostate cancer stem cells. Hagiwara M, Fushimi A, Yamashita N, Bhattacharya A, Rajabi H, Long MD, Yasumizu Y, Oya M, Liu S, Kufe D. Oncogene. 2021 Jul;40(30):4930-4940. doi: 10.1038/s41388-021-01899-y. Epub 2021 Jun 23. PubMed
NUDT15-mediated hydrolysis limits the efficacy of anti-HCMV drug ganciclovir. Zhang SM, Rehling D, Jemth AS, Throup A, Landazuri N, Almlof I, Gottmann M, Valerie NCK, Borhade SR, Wakchaure P, Page BDG, Desroses M, Homan EJ, Scobie M, Rudd SG, Berglund UW, Soderberg-Naucler C, Stenmark P, Helleday T. Cell Chem Biol. 2021 Jun 22. pii: S2451-9456(21)00268-3. doi: 10.1016/j.chembiol.2021.06.001. PubMed
Downregulation of CRX, a Group 3-specific oncogenic transcription factor, inhibits TGF-beta/activin signaling in medulloblastoma cells. Masurkar SA, Deogharkar A, Bharambe HS, Shirsat NV. Biochem Biophys Res Commun. 2021 Sep 3;568:76-82. doi: 10.1016/j.bbrc.2021.06.064. Epub 2021 Jun 27. PubMed
Oncogenic KRAS creates an aspartate metabolism signature in colorectal cancer cells. Doubleday PF, Fornelli L, Ntai I, Kelleher NL. FEBS J. 2021 Dec;288(23):6683-6699. doi: 10.1111/febs.16111. Epub 2021 Jul 27. PubMed
Prognostic role and biologic features of Musashi-2 expression in colon polyps and during colorectal cancer progression. Kharin L, Bychkov I, Karnaukhov N, Voloshin M, Fazliyeva R, Deneka A, Frantsiyants E, Kit O, Golemis E, Boumber Y. PLoS One. 2021 Jul 8;16(7):e0252132. doi: 10.1371/journal.pone.0252132. eCollection 2021. PubMed
Cholesterol auxotrophy as a targetable vulnerability in clear cell renal cell carcinoma. Riscal R, Bull CJ, Mesaros C, Finan JM, Carens M, Ho ES, Xu JP, Godfrey J, Brennan P, Johansson M, Purdue MP, Chanock SJ, Mariosa D, Timpson NJ, Vincent EE, Keith B, Blair IA, Skuli N, Simon MC. Cancer Discov. 2021 Jul 8. pii: 2159-8290.CD-21-0211. doi: 10.1158/2159-8290.CD-21-0211. PubMed
Non-canonical H3K79me2-dependent pathways promote the survival of MLL-rearranged leukemia. Richter WF, Shah RN, Ruthenburg AJ. Elife. 2021 Jul 15;10. pii: 64960. doi: 10.7554/eLife.64960. PubMed Associated Plasmids pBR-Lent-STAT5A-CA
Metformin and Niclosamide Synergistically Suppress Wnt and YAP in APC-Mutated Colorectal Cancer. Kang HE, Seo Y, Yun JS, Song SH, Han D, Cho ES, Cho SB, Jeon Y, Lee H, Kim HS, Kang J, Yook JI, Kim NH, Kim TI. Cancers (Basel). 2021 Jul 9;13(14). pii: cancers13143437. doi: 10.3390/cancers13143437. PubMed
PRMT1-dependent regulation of RNA metabolism and DNA damage response sustains pancreatic ductal adenocarcinoma. Giuliani V, Miller MA, Liu CY, Hartono SR, Class CA, Bristow CA, Suzuki E, Sanz LA, Gao G, Gay JP, Feng N, Rose JL, Tomihara H, Daniele JR, Peoples MD, Bardenhagen JP, Geck Do MK, Chang QE, Vangamudi B, Vellano C, Ying H, Deem AK, Do KA, Genovese G, Marszalek JR, Kovacs JJ, Kim M, Fleming JB, Guccione E, Viale A, Maitra A, Emilia Di Francesco M, Yap TA, Jones P, Draetta G, Carugo A, Chedin F, Heffernan TP. Nat Commun. 2021 Jul 30;12(1):4626. doi: 10.1038/s41467-021-24798-y. PubMed
Unveiling the Roles of Low-Density Lipoprotein Receptor-Related Protein 6 in Intestinal Homeostasis, Regeneration and Oncogenesis. Raisch J, Cote-Biron A, Langlois MJ, Leblanc C, Rivard N. Cells. 2021 Jul 15;10(7). pii: cells10071792. doi: 10.3390/cells10071792. PubMed
GOT1 inhibition promotes pancreatic cancer cell death by ferroptosis. Kremer DM, Nelson BS, Lin L, Yarosz EL, Halbrook CJ, Kerk SA, Sajjakulnukit P, Myers A, Thurston G, Hou SW, Carpenter ES, Andren AC, Nwosu ZC, Cusmano N, Wisner S, Mbah NE, Shan M, Das NK, Magnuson B, Little AC, Savani MR, Ramos J, Gao T, Sastra SA, Palermo CF, Badgley MA, Zhang L, Asara JM, McBrayer SK, di Magliano MP, Crawford HC, Shah YM, Olive KP, Lyssiotis CA. Nat Commun. 2021 Aug 11;12(1):4860. doi: 10.1038/s41467-021-24859-2. PubMed
ZNF768 links oncogenic RAS to cellular senescence. Villot R, Poirier A, Bakan I, Boulay K, Fernandez E, Devillers R, Gama-Braga L, Tribouillard L, Gagne A, Duchesne E, Caron D, Berube JS, Berube JC, Coulombe Y, Orain M, Gelinas Y, Gobeil S, Bosse Y, Masson JY, Elowe S, Bilodeau S, Manem V, Joubert P, Mallette FA, Laplante M. Nat Commun. 2021 Aug 17;12(1):4841. doi: 10.1038/s41467-021-24932-w. PubMed
Identification of Androgen Receptor Metabolic Correlome Reveals the Repression of Ceramide Kinase by Androgens. Camacho L, Zabala-Letona A, Cortazar AR, Astobiza I, Dominguez-Herrera A, Ercilla A, Crespo J, Viera C, Fernandez-Ruiz S, Martinez-Gonzalez A, Torrano V, Martin-Martin N, Gomez-Munoz A, Carracedo A. Cancers (Basel). 2021 Aug 26;13(17). pii: cancers13174307. doi: 10.3390/cancers13174307. PubMed
Therapeutic inhibition of USP9x-mediated Notch signaling in triple-negative breast cancer. Jaiswal A, Murakami K, Elia A, Shibahara Y, Done SJ, Wood SA, Donato NJ, Ohashi PS, Reedijk M. Proc Natl Acad Sci U S A. 2021 Sep 21;118(38). pii: 2101592118. doi: 10.1073/pnas.2101592118. PubMed
The Knockdown of Nrf2 Suppressed Tumor Growth and Increased the Sensitivity to Lenvatinib in Anaplastic Thyroid Cancer. Gong Z, Xue L, Wei M, Liu Z, Vlantis AC, van Hasselt CA, Chan JYK, Li D, Zeng X, Tong MCF, Chen GG. Oxid Med Cell Longev. 2021 Sep 4;2021:3900330. doi: 10.1155/2021/3900330. eCollection 2021. PubMed
Therapeutic targeting of the PLK1-PRC1-axis triggers cell death in genomically silent childhood cancer. Li J, Ohmura S, Marchetto A, Orth MF, Imle R, Dallmayer M, Musa J, Knott MML, Holting TLB, Stein S, Funk CM, Sastre A, Alonso J, Bestvater F, Kasan M, Romero-Perez L, Hartmann W, Ranft A, Banito A, Dirksen U, Kirchner T, Cidre-Aranaz F, Grunewald TGP. Nat Commun. 2021 Sep 16;12(1):5356. doi: 10.1038/s41467-021-25553-z. PubMed
Sex-Biased ZRSR2 Mutations in Myeloid Malignancies Impair Plasmacytoid Dendritic Cell Activation and Apoptosis. Togami K, Chung SS, Madan V, Booth CAG, Kenyon CM, Cabal-Hierro L, Taylor J, Kim SS, Griffin GK, Ghandi M, Li J, Li YY, Angelot-Delettre F, Biichle S, Seiler M, Buonamici S, Lovitch SB, Louissaint A Jr, Morgan EA, Jardin F, Piccaluga PP, Weinstock DM, Hammerman PS, Yang H, Konopleva M, Pemmaraju N, Garnache-Ottou F, Abdel-Wahab O, Koeffler HP, Lane AA. Cancer Discov. 2022 Feb;12(2):522-541. doi: 10.1158/2159-8290.CD-20-1513. Epub 2021 Oct 6. PubMed
Differential Ubiquitination as an Effective Strategy Employed by the Blood-Brain Barrier for Prevention of Bacterial Transcytosis. Bhutda S, Ghosh S, Sinha AR, Santra S, Hiray A, Banerjee A. J Bacteriol. 2022 Jan 18;204(1):e0045621. doi: 10.1128/JB.00456-21. Epub 2021 Oct 11. PubMed
Plexin-B2 orchestrates collective stem cell dynamics via actomyosin contractility, cytoskeletal tension and adhesion. Junqueira Alves C, Dariolli R, Haydak J, Kang S, Hannah T, Wiener RJ, DeFronzo S, Tejero R, Gusella GL, Ramakrishnan A, Alves Dias R, Wojcinski A, Kesari S, Shen L, Sobie EA, Rodrigues Furtado de Mendonca JP, Azeloglu EU, Zou H, Friedel RH. Nat Commun. 2021 Oct 14;12(1):6019. doi: 10.1038/s41467-021-26296-7. PubMed Associated Plasmids pLKO-Tet-On-shRNA-Control pLKO-Tet-On-PLXNB2-shRNA1 pLKO-Tet-On-PLXNB2-shRNA2 pLenti-PGK-RAP1A-WT-puro pLenti-PGK-RAP1A-E63-puro More ...
MUC1-C dictates neuroendocrine lineage specification in pancreatic ductal adenocarcinomas. Luan Z, Morimoto Y, Fushimi A, Yamashita N, Suo W, Bhattacharya A, Hagiwara M, Jin C, Kufe D. Carcinogenesis. 2022 Feb 11;43(1):67-76. doi: 10.1093/carcin/bgab097. PubMed
Co-occurrence of BAP1 and SF3B1 mutations in uveal melanoma induces cellular senescence. Yu L, Zhou D, Zhang G, Ren Z, Luo X, Liu P, Plouffe SW, Meng Z, Moroishi T, Li Y, Zhang Y, Brown JH, Liu S, Guan KL. Mol Oncol. 2022 Feb;16(3):607-629. doi: 10.1002/1878-0261.13128. Epub 2021 Nov 12. PubMed
IL-17B/RB Activation in Pancreatic Stellate Cells Promotes Pancreatic Cancer Metabolism and Growth. Li J, Wu X, Schiffmann L, MacVicar T, Zhou C, Wang Z, Li D, Camacho OV, Heuchel R, Odenthal M, Hillmer A, Quaas A, Zhao Y, Bruns CJ, Popp FC. Cancers (Basel). 2021 Oct 24;13(21). pii: cancers13215338. doi: 10.3390/cancers13215338. PubMed
Mitophagy mediates metabolic reprogramming of induced pluripotent stem cells undergoing endothelial differentiation. Krantz S, Kim YM, Srivastava S, Leasure JW, Toth PT, Marsboom G, Rehman J. J Biol Chem. 2021 Dec;297(6):101410. doi: 10.1016/j.jbc.2021.101410. Epub 2021 Nov 14. PubMed
EWSR1-WT1 Target Genes and Therapeutic Options Identified in a Novel DSRCT In Vitro Model. Bleijs M, Pleijte C, Engels S, Ringnalda F, Meyer-Wentrup F, van de Wetering M, Clevers H. Cancers (Basel). 2021 Dec 2;13(23). pii: cancers13236072. doi: 10.3390/cancers13236072. PubMed
MUC1-C Dictates JUN and BAF-Mediated Chromatin Remodeling at Enhancer Signatures in Cancer Stem Cells. Bhattacharya A, Fushimi A, Yamashita N, Hagiwara M, Morimoto Y, Rajabi H, Long MD, Abdulla M, Ahmad R, Street K, Liu S, Liu T, Kufe D. Mol Cancer Res. 2022 Apr 1;20(4):556-567. doi: 10.1158/1541-7786.MCR-21-0672. PubMed
A Selective Small-Molecule c-Myc Degrader Potently Regresses Lethal c-Myc Overexpressing Tumors. Xu Y, Yu Q, Wang P, Wu Z, Zhang L, Wu S, Li M, Wu B, Li H, Zhuang H, Zhang X, Huang Y, Gan X, Xu R. Adv Sci (Weinh). 2022 Mar;9(8):e2104344. doi: 10.1002/advs.202104344. Epub 2022 Jan 20. PubMed
Inactivation of p21-Activated Kinase 2 (Pak2) Inhibits the Development of Nf2-Deficient Tumors by Restricting Downstream Hedgehog and Wnt Signaling. Sementino E, Kadariya Y, Cheung M, Menges CW, Tan Y, Kukuyan AM, Shrestha U, Karchugina S, Cai KQ, Peri S, Duncan JS, Chernoff J, Testa JR. Mol Cancer Res. 2022 May 4;20(5):699-711. doi: 10.1158/1541-7786.MCR-21-0837. PubMed
shRNAs targeting mouse Adam10 diminish cell response to proinflammatory stimuli independently of Adam10 silencing. Czarnek M, Stalinska K, Sarad K, Bereta J. Biol Open. 2022 Mar 15;11(3). pii: 274200. doi: 10.1242/bio.059092. Epub 2022 Mar 4. PubMed
A non-catalytic scaffolding activity of hexokinase 2 contributes to EMT and metastasis. Blaha CS, Ramakrishnan G, Jeon SM, Nogueira V, Rho H, Kang S, Bhaskar P, Terry AR, Aissa AF, Frolov MV, Patra KC, Brooks Robey R, Hay N. Nat Commun. 2022 Feb 16;13(1):899. doi: 10.1038/s41467-022-28440-3. PubMed
EZH2 noncanonically binds cMyc and p300 through a cryptic transactivation domain to mediate gene activation and promote oncogenesis. Wang J, Yu X, Gong W, Liu X, Park KS, Ma A, Tsai YH, Shen Y, Onikubo T, Pi WC, Allison DF, Liu J, Chen WY, Cai L, Roeder RG, Jin J, Wang GG. Nat Cell Biol. 2022 Mar;24(3):384-399. doi: 10.1038/s41556-022-00850-x. Epub 2022 Feb 24. PubMed
YAP regulates an SGK1/mTORC1/SREBP-dependent lipogenic program to support proliferation and tissue growth. Vaidyanathan S, Salmi TM, Sathiqu RM, McConville MJ, Cox AG, Brown KK. Dev Cell. 2022 Mar 28;57(6):719-731.e8. doi: 10.1016/j.devcel.2022.02.004. Epub 2022 Feb 24. PubMed
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