mTOR_1 shRNA Citations (19)
Originally described in: Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex.Sarbassov DD, Guertin DA, Ali SM, Sabatini DM Science 2005 Feb 18;307(5712):1098-101. PubMed Journal
Articles Citing mTOR_1 shRNA
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| Human cytomegalovirus infection alters the substrate specificities and rapamycin sensitivities of raptor- and rictor-containing complexes. Kudchodkar SB, Yu Y, Maguire TG, Alwine JC. Proc Natl Acad Sci U S A. 2006 Sep 19. 103(38):14182-7. PubMed |
PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding.
Wang L, Harris TE, Roth RA, Lawrence JC.
J Biol Chem. 2007 Jul 6. 282(27):20036-44.
PubMed
Associated Plasmids |
| TORC-specific phosphorylation of mammalian target of rapamycin (mTOR): phospho-Ser2481 is a marker for intact mTOR signaling complex 2. Copp J, Manning G, Hunter T. Cancer Res. 2009 Mar 1. 69(5):1821-7. PubMed |
| Ribavirin enhances interferon signaling via stimulation of mTOR and p53 activities. Su WC, Liu WL, Cheng CW, Chou YB, Hung KH, Huang WH, Wu CL, Li YT, Shiau AL, Lai MY. FEBS Lett. 2009 Sep 3;583(17):2793-8. doi: 10.1016/j.febslet.2009.07.027. Epub 2009 Jul 18. PubMed |
| Angiocrine factors from Akt-activated endothelial cells balance self-renewal and differentiation of haematopoietic stem cells. Kobayashi H, Butler JM, O'Donnell R, Kobayashi M, Ding BS, Bonner B, Chiu VK, Nolan DJ, Shido K, Benjamin L, Rafii S. Nat Cell Biol. 2010 Nov;12(11):1046-56. doi: 10.1038/ncb2108. Epub 2010 Oct 24. PubMed |
| Inhibition of mTOR kinase by AZD8055 can antagonize chemotherapy-induced cell death through autophagy induction and down-regulation of p62/sequestosome 1. Huang S, Yang ZJ, Yu C, Sinicrope FA. J Biol Chem. 2011 Nov 18;286(46):40002-12. doi: 10.1074/jbc.M111.297432. Epub 2011 Sep 23. PubMed |
| Autophagy is a protective response to ethanol neurotoxicity. Chen G, Ke Z, Xu M, Liao M, Wang X, Qi Y, Zhang T, Frank JA, Bower KA, Shi X, Luo J. Autophagy. 2012 Nov;8(11):1577-89. doi: 10.4161/auto.21376. Epub 2012 Aug 9. PubMed |
| mTOR regulates lysosomal ATP-sensitive two-pore Na(+) channels to adapt to metabolic state. Cang C, Zhou Y, Navarro B, Seo YJ, Aranda K, Shi L, Battaglia-Hsu S, Nissim I, Clapham DE, Ren D. Cell. 2013 Feb 14;152(4):778-90. doi: 10.1016/j.cell.2013.01.023. Epub 2013 Feb 7. PubMed |
| Mammalian target of rapamycin (mTor) mediates tau protein dyshomeostasis: implication for Alzheimer disease. Tang Z, Bereczki E, Zhang H, Wang S, Li C, Ji X, Branca RM, Lehtio J, Guan Z, Filipcik P, Xu S, Winblad B, Pei JJ. J Biol Chem. 2013 May 31;288(22):15556-70. doi: 10.1074/jbc.M112.435123. Epub 2013 Apr 12. PubMed |
| Genetic and pharmacologic inhibition of mTORC1 promotes EMT by a TGF-beta-independent mechanism. Mikaelian I, Malek M, Gadet R, Viallet J, Garcia A, Girard-Gagnepain A, Hesling C, Gillet G, Gonzalo P, Rimokh R, Billaud M. Cancer Res. 2013 Nov 15;73(22):6621-31. doi: 10.1158/0008-5472.CAN-13-0560. Epub 2013 Sep 27. PubMed |
| mTOR regulates phagosome and entotic vacuole fission. Krajcovic M, Krishna S, Akkari L, Joyce JA, Overholtzer M. Mol Biol Cell. 2013 Dec;24(23):3736-45. doi: 10.1091/mbc.E13-07-0408. Epub 2013 Oct 2. PubMed |
| Prostate cancer ETS rearrangements switch a cell migration gene expression program from RAS/ERK to PI3K/AKT regulation. Selvaraj N, Budka JA, Ferris MW, Jerde TJ, Hollenhorst PC. Mol Cancer. 2014 Mar 19;13:61. doi: 10.1186/1476-4598-13-61. PubMed |
Lanthionine synthetase C-like protein 2 (LanCL2) is a novel regulator of Akt.
Zeng M, van der Donk WA, Chen J.
Mol Biol Cell. 2014 Dec 1;25(24):3954-61. doi: 10.1091/mbc.E14-01-0004. Epub 2014 Oct 1.
PubMed
Associated Plasmids |
| mTOR inhibition decreases SOX2-SOX9 mediated glioma stem cell activity and temozolomide resistance. Garros-Regulez L, Aldaz P, Arrizabalaga O, Moncho-Amor V, Carrasco-Garcia E, Manterola L, Moreno-Cugnon L, Barrena C, Villanua J, Ruiz I, Pollard S, Lovell-Badge R, Sampron N, Garcia I, Matheu A. Expert Opin Ther Targets. 2016;20(4):393-405. doi: 10.1517/14728222.2016.1151002. PubMed |
| RACK1 is an Interaction Partner of ATG5 and a Novel Regulator of Autophagy. Erbil S, Oral O, Mitou G, Kig C, Durmaz-Timucin E, Guven-Maiorov E, Gulacti F, Gokce G, Dengjel J, Sezerman OU, Gozuacik D. J Biol Chem. 2016 Jun 20. pii: jbc.M115.708081. PubMed |
| Accumulation of autophagosomes confers cytotoxicity. Button RW, Roberts SL, Willis TL, Hanemann CO, Luo S. J Biol Chem. 2017 Jul 3. pii: jbc.M117.782276. doi: 10.1074/jbc.M117.782276. PubMed |
| FLT3-ITD induces expression of Pim kinases through STAT5 to confer resistance to the PI3K/Akt pathway inhibitors on leukemic cells by enhancing the mTORC1/Mcl-1 pathway. Okada K, Nogami A, Ishida S, Akiyama H, Chen C, Umezawa Y, Miura O. Oncotarget. 2017 Dec 4;9(10):8870-8886. doi: 10.18632/oncotarget.22926. eCollection 2018 Feb 6. PubMed |
| An Excitable Ras/PI3K/ERK Signaling Network Controls Migration and Oncogenic Transformation in Epithelial Cells. Zhan H, Bhattacharya S, Cai H, Iglesias PA, Huang CH, Devreotes PN. Dev Cell. 2020 Sep 14;54(5):608-623.e5. doi: 10.1016/j.devcel.2020.08.001. Epub 2020 Sep 1. PubMed |
| mTORC1 induces eukaryotic translation initiation factor 4E interaction with TOS-S6 kinase 1 and its activation. Majeed ST, Batool A, Majeed R, Bhat NN, Zargar MA, Andrabi KI. Cell Cycle. 2021 May;20(9):839-854. doi: 10.1080/15384101.2021.1901038. Epub 2021 May 3. PubMed |
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