pCS2-MT GLI2 FL Citations (16)
Originally described in: A previously unidentified amino-terminal domain regulates transcriptional activity of wild-type and disease-associated human GLI2.Roessler E, Ermilov AN, Grange DK, Wang A, Grachtchouk M, Dlugosz AA, Muenke M Hum Mol Genet. 2005 Aug 1. 14(15):2181-8. PubMed Journal
Articles Citing pCS2-MT GLI2 FL
| Articles |
|---|
| Sonic hedgehog regulates presynaptic terminal size, ultrastructure and function in hippocampal neurons. Mitchell N, Petralia RS, Currier DG, Wang YX, Kim A, Mattson MP, Yao PJ. J Cell Sci. 2012 Sep 15;125(Pt 18):4207-13. doi: 10.1242/jcs.105080. Epub 2012 May 28. PubMed |
| Regulation of the bone-restricted IFITM-like (Bril) gene transcription by Sp and Gli family members and CpG methylation. Kasaai B, Gaumond MH, Moffatt P. J Biol Chem. 2013 May 10;288(19):13278-94. doi: 10.1074/jbc.M113.457010. Epub 2013 Mar 24. PubMed |
| Indian hedgehog signaling regulates transcription and expression of collagen type X via Runx2/Smads interactions. Amano K, Densmore M, Nishimura R, Lanske B. J Biol Chem. 2014 Sep 5;289(36):24898-910. doi: 10.1074/jbc.M114.570507. Epub 2014 Jul 15. PubMed |
| Repurposing the antihelmintic mebendazole as a hedgehog inhibitor. Larsen AR, Bai RY, Chung JH, Borodovsky A, Rudin CM, Riggins GJ, Bunz F. Mol Cancer Ther. 2015 Jan;14(1):3-13. doi: 10.1158/1535-7163.MCT-14-0755-T. Epub 2014 Nov 5. PubMed |
| Pharmacological GLI2 inhibition prevents myofibroblast cell-cycle progression and reduces kidney fibrosis. Kramann R, Fleig SV, Schneider RK, Fabian SL, DiRocco DP, Maarouf O, Wongboonsin J, Ikeda Y, Heckl D, Chang SL, Rennke HG, Waikar SS, Humphreys BD. J Clin Invest. 2015 Aug 3;125(8):2935-51. doi: 10.1172/JCI74929. Epub 2015 Jul 20. PubMed |
| Gli1-Mediated Regulation of Sox2 Facilitates Self-Renewal of Stem-Like Cells and Confers Resistance to EGFR Inhibitors in Non-Small Cell Lung Cancer. Bora-Singhal N, Perumal D, Nguyen J, Chellappan S. Neoplasia. 2015 Jul;17(7):538-51. doi: 10.1016/j.neo.2015.07.001. PubMed |
| Survivin, a novel target of the Hedgehog/GLI signaling pathway in human tumor cells. Vlckova K, Ondrusova L, Vachtenheim J, Reda J, Dundr P, Zadinova M, Zakova P, Pouckova P. Cell Death Dis. 2016 Jan 14;7:e2048. doi: 10.1038/cddis.2015.389. PubMed |
| mTORC1 regulates PTHrP to coordinate chondrocyte growth, proliferation and differentiation. Yan B, Zhang Z, Jin D, Cai C, Jia C, Liu W, Wang T, Li S, Zhang H, Huang B, Lai P, Wang H, Liu A, Zeng C, Cai D, Jiang Y, Bai X. Nat Commun. 2016 Apr 4;7:11151. doi: 10.1038/ncomms11151. PubMed |
| mTORC2 regulates hedgehog pathway activity by promoting stability to Gli2 protein and its nuclear translocation. Maiti S, Mondal S, Satyavarapu EM, Mandal C. Cell Death Dis. 2017 Jul 13;8(7):e2926. doi: 10.1038/cddis.2017.296. PubMed |
| Novel GLI2 mutations identified in patients with Combined Pituitary Hormone Deficiency (CPHD): Evidence for a pathogenic effect by functional characterization. Babu D, Fanelli A, Mellone S, Muniswamy R, Wasniewska M, Prodam F, Petri A, Bellone S, Salerno MC, Giordano M. Clin Endocrinol (Oxf). 2019 Mar;90(3):449-456. doi: 10.1111/cen.13914. Epub 2019 Jan 7. PubMed |
| A novel truncating variant of GLI2 associated with Culler-Jones syndrome impairs Hedgehog signalling. Valenza F, Cittaro D, Stupka E, Biancolini D, Patricelli MG, Bonanomi D, Lazarevic D. PLoS One. 2019 Jan 10;14(1):e0210097. doi: 10.1371/journal.pone.0210097. eCollection 2019. PubMed |
| Gli2 mediates the development of castrationresistant prostate cancer. Xia L, Bouamar H, Gu X, Zeballos C, Qin T, Wang B, Zhou Y, Wang Y, Yang J, Zhu H, Zhang W, Houghton PJ, Sun LZ. Int J Oncol. 2020 Jul;57(1):100-112. doi: 10.3892/ijo.2020.5044. Epub 2020 Apr 13. PubMed |
| ABT-199 inhibits Hedgehog pathway by acting as a competitive inhibitor of oxysterol, rather as a BH3 mimetic. Wang J, Zhang Y, Huang WJ, Yang J, Tang WG, Huang TM, Tan WF. Acta Pharmacol Sin. 2021 Jun;42(6):1005-1013. doi: 10.1038/s41401-020-00504-4. Epub 2020 Aug 27. PubMed |
| PGE2-JNK signaling axis non-canonically promotes Gli activation by protecting Gli2 from ubiquitin-proteasomal degradation. Yang J, Wang J, Liu Y, Zhang Y, Huang W, Zou Y, Qiu Y, Cai W, Gao J, Zhou H, Wu Y, Liu W, Ding Q, Zhang Y, Yin PH, Tan W. Cell Death Dis. 2021 Jul 15;12(7):707. doi: 10.1038/s41419-021-03995-z. PubMed |
| Noncanonical activation of GLI signaling in SOX2(+) cells drives medulloblastoma relapse. Swiderska-Syn M, Mir-Pedrol J, Oles A, Schleuger O, Salvador AD, Greiner SM, Seward C, Yang F, Babcock BR, Shen C, Wynn DT, Sanchez-Mejias A, Gershon TR, Martin V, McCrea HJ, Lindsey KG, Krieg C, Rodriguez-Blanco J. Sci Adv. 2022 Jul 22;8(29):eabj9138. doi: 10.1126/sciadv.abj9138. Epub 2022 Jul 20. PubMed |
| c-Jun phosphorylated by JNK is required for protecting Gli2 from proteasomal-ubiquitin degradation by PGE2-JNK signaling axis. Yang J, Wang J, Zhang Y, Huang W, Zhang S, Yin P, Tan W. Biochim Biophys Acta Mol Cell Res. 2023 Mar;1870(3):119418. doi: 10.1016/j.bbamcr.2022.119418. Epub 2022 Dec 27. PubMed |
If you have published an article using this material, please email us at [email protected] to have your article added to this page.