Skip to main content
Addgene

pBabe-Puro-MEK-DD Citations (26)

Originally described in: Integrative Genomic Approaches Identify IKBKE as a Breast Cancer Oncogene.
Boehm JS, Zhao JJ, Yao J, Kim SY, Firestein R, Dunn IF, Sjostrom SK, Garraway LA, Weremowicz S, Richardson AL, Greulich H, Stewart CJ, Mulvey LA, Shen RR, Ambrogio L, Hirozane-Kishikawa T, Hill DE, Vidal M, Meyerson M, Grenier JK, Hinkle G, Root DE, Roberts TM, Lander ES, Polyak K, Hahn WC Cell. 2007 Jun 15. 129(6):1065-1079. PubMed Journal

Articles Citing pBabe-Puro-MEK-DD

Articles
Albumin-induced apoptosis of glomerular parietal epithelial cells is modulated by extracellular signal-regulated kinase 1/2. Chang AM, Ohse T, Krofft RD, Wu JS, Eddy AA, Pippin JW, Shankland SJ. Nephrol Dial Transplant. 2012 Apr;27(4):1330-43. doi: 10.1093/ndt/gfr483. Epub 2011 Sep 5. PubMed
c-MYC functions as a molecular switch to alter the response of human mammary epithelial cells to oncostatin M. Kan CE, Cipriano R, Jackson MW. Cancer Res. 2011 Nov 15;71(22):6930-9. doi: 10.1158/0008-5472.CAN-10-3860. Epub 2011 Oct 5. PubMed
CXCL12/CXCR4 protein signaling axis induces sonic hedgehog expression in pancreatic cancer cells via extracellular regulated kinase- and Akt kinase-mediated activation of nuclear factor kappaB: implications for bidirectional tumor-stromal interactions. Singh AP, Arora S, Bhardwaj A, Srivastava SK, Kadakia MP, Wang B, Grizzle WE, Owen LB, Singh S. J Biol Chem. 2012 Nov 9;287(46):39115-24. doi: 10.1074/jbc.M112.409581. Epub 2012 Sep 20. PubMed
A high-throughput assay for phosphoprotein-specific phosphatase activity in cellular extracts. Bose AK, Janes KA. Mol Cell Proteomics. 2013 Mar;12(3):797-806. doi: 10.1074/mcp.O112.024059. Epub 2012 Dec 11. PubMed

Associated Plasmids
The transcription factor NFAT1 induces apoptosis through cooperation with Ras/Raf/MEK/ERK pathway and upregulation of TNF-alpha expression. Robbs BK, Lucena PI, Viola JP. Biochim Biophys Acta. 2013 Aug;1833(8):2016-28. doi: 10.1016/j.bbamcr.2013.04.003. Epub 2013 Apr 10. PubMed
FAM83B-mediated activation of PI3K/AKT and MAPK signaling cooperates to promote epithelial cell transformation and resistance to targeted therapies. Cipriano R, Miskimen KL, Bryson BL, Foy CR, Bartel CA, Jackson MW. Oncotarget. 2013 May;4(5):729-38. PubMed
RAS-MAPK-MSK1 pathway modulates ataxin 1 protein levels and toxicity in SCA1. Park J, Al-Ramahi I, Tan Q, Mollema N, Diaz-Garcia JR, Gallego-Flores T, Lu HC, Lagalwar S, Duvick L, Kang H, Lee Y, Jafar-Nejad P, Sayegh LS, Richman R, Liu X, Gao Y, Shaw CA, Arthur JS, Orr HT, Westbrook TF, Botas J, Zoghbi HY. Nature. 2013 Jun 20;498(7454):325-31. doi: 10.1038/nature12204. Epub 2013 May 29. PubMed
DUSP6 regulates drug sensitivity by modulating DNA damage response. Bagnyukova TV, Restifo D, Beeharry N, Gabitova L, Li T, Serebriiskii IG, Golemis EA, Astsaturov I. Br J Cancer. 2013 Aug 20;109(4):1063-71. doi: 10.1038/bjc.2013.353. Epub 2013 Jul 9. PubMed

Associated Plasmids
miR-146a promotes the initiation and progression of melanoma by activating Notch signaling. Forloni M, Dogra SK, Dong Y, Conte D Jr, Ou J, Zhu LJ, Deng A, Mahalingam M, Green MR, Wajapeyee N. Elife. 2014 Feb 18;3:e01460. doi: 10.7554/eLife.01460. PubMed
ERK/MAPK regulates ERRgamma expression, transcriptional activity, and receptor-mediated Tamoxifen resistance in ER+ breast cancer. Heckler MM, Thakor H, Schafer CC, Riggins RB. FEBS J. 2014 Mar 29. doi: 10.1111/febs.12797. PubMed

Associated Plasmids
ERK-regulated alphaB-crystallin induction by matrix detachment inhibits anoikis and promotes lung metastasis in vivo. Malin D, Strekalova E, Petrovic V, Rajanala H, Sharma B, Ugolkov A, Gradishar WJ, Cryns VL. Oncogene. 2015 Feb 16. doi: 10.1038/onc.2015.12. PubMed
Spinophilin-Targeted Protein Phosphatase-1 Alleviated Inflammatory Pain by Negative Control of MEK/ERK Signaling in Spinal Cord Dorsal Horn of Rats. Hu XD, Liu YN, Zhang ZY, Ma ZA, Suo ZW, Yang X. J Neurosci. 2015 Oct 14;35(41):13989-4001. doi: 10.1523/JNEUROSCI.2293-15.2015. PubMed
Interferon alpha-inducible protein 6 regulates NRASQ61K-induced melanomagenesis and growth. Gupta R, Forloni M, Bisserier M, Dogra SK, Yang Q, Wajapeyee N. Elife. 2016 Sep 8;5. pii: e16432. doi: 10.7554/eLife.16432. PubMed
Inhibition of RAS function through targeting an allosteric regulatory site. Spencer-Smith R, Koide A, Zhou Y, Eguchi RR, Sha F, Gajwani P, Santana D, Gupta A, Jacobs M, Herrero-Garcia E, Cobbert J, Lavoie H, Smith M, Rajakulendran T, Dowdell E, Okur MN, Dementieva I, Sicheri F, Therrien M, Hancock JF, Ikura M, Koide S, O'Bryan JP. Nat Chem Biol. 2016 Nov 7. doi: 10.1038/nchembio.2231. PubMed

Associated Plasmids
Activation of MAPK/ERK signaling by Burkholderia pseudomallei cycle inhibiting factor (Cif). Ng MY, Wang M, Casey PJ, Gan YH, Hagen T. PLoS One. 2017 Feb 6;12(2):e0171464. doi: 10.1371/journal.pone.0171464. eCollection 2017. PubMed
The Intellectual Disability and Schizophrenia Associated Transcription Factor TCF4 Is Regulated by Neuronal Activity and Protein Kinase A. Sepp M, Vihma H, Nurm K, Urb M, Page SC, Roots K, Hark A, Maher BJ, Pruunsild P, Timmusk T. J Neurosci. 2017 Oct 25;37(43):10516-10527. doi: 10.1523/JNEUROSCI.1151-17.2017. Epub 2017 Sep 26. PubMed
Targeting CDK1 and MEK/ERK Overcomes Apoptotic Resistance in BRAF-Mutant Human Colorectal Cancer. Zhang P, Kawakami H, Liu W, Zeng X, Strebhardt K, Tao K, Huang S, Sinicrope FA. Mol Cancer Res. 2018 Mar;16(3):378-389. doi: 10.1158/1541-7786.MCR-17-0404. Epub 2017 Dec 12. PubMed
Characterisation of cellular effects of Burkholderia pseudomallei cycle inhibiting factor (Cif). Ng MY, Gan YH, Hagen T. Biol Open. 2018 Jul 16;7(7). pii: bio.028225. doi: 10.1242/bio.028225. PubMed
Dermatopontin inhibits papillary thyroid cancer cell proliferation through MYC repression. Guo Y, Li H, Guan H, Ke W, Liang W, Xiao H, Li Y. Mol Cell Endocrinol. 2019 Jan 15;480:122-132. doi: 10.1016/j.mce.2018.10.021. Epub 2018 Nov 2. PubMed
Differential Subcellular Localization Regulates Oncogenic Signaling by ROS1 Kinase Fusion Proteins. Neel DS, Allegakoen DV, Olivas V, Mayekar MK, Hemmati G, Chatterjee N, Blakely CM, McCoach CE, Rotow JK, Le A, Karachaliou N, Rosell R, Riess JW, Nichols R, Doebele RC, Bivona TG. Cancer Res. 2019 Feb 1;79(3):546-556. doi: 10.1158/0008-5472.CAN-18-1492. Epub 2018 Dec 11. PubMed
mGluR5/ERK signaling regulated the phosphorylation and function of glycine receptor alpha1ins subunit in spinal dorsal horn of mice. Zhang ZY, Bai HH, Guo Z, Li HL, He YT, Duan XL, Suo ZW, Yang X, He YX, Hu XD. PLoS Biol. 2019 Aug 21;17(8):e3000371. doi: 10.1371/journal.pbio.3000371. eCollection 2019 Aug. PubMed
Mechanical stretch induces myelin protein loss in oligodendrocytes by activating Erk1/2 in a calcium-dependent manner. Kim J, Adams AA, Gokina P, Zambrano B, Jayakumaran J, Dobrowolski R, Maurel P, Pfister BJ, Kim HA. Glia. 2020 Oct;68(10):2070-2085. doi: 10.1002/glia.23827. Epub 2020 Mar 14. PubMed
Cholesterol Pathway Inhibition Induces TGF-beta Signaling to Promote Basal Differentiation in Pancreatic Cancer. Gabitova-Cornell L, Surumbayeva A, Peri S, Franco-Barraza J, Restifo D, Weitz N, Ogier C, Goldman AR, Hartman TR, Francescone R, Tan Y, Nicolas E, Shah N, Handorf EA, Cai KQ, O'Reilly AM, Sloma I, Chiaverelli R, Moffitt RA, Khazak V, Fang CY, Golemis EA, Cukierman E, Astsaturov I. Cancer Cell. 2020 Oct 12;38(4):567-583.e11. doi: 10.1016/j.ccell.2020.08.015. Epub 2020 Sep 24. PubMed
SYK inhibition targets acute myeloid leukemia stem cells by blocking their oxidative metabolism. Polak A, Bialopiotrowicz E, Krzymieniewska B, Wozniak J, Stojak M, Cybulska M, Kaniuga E, Mikula M, Jablonska E, Gorniak P, Noyszewska-Kania M, Szydlowski M, Piechna K, Piwocka K, Bugajski L, Lech-Maranda E, Barankiewicz J, Kolkowska-Lesniak A, Patkowska E, Glodkowska-Mrowka E, Baran N, Juszczynski P. Cell Death Dis. 2020 Nov 6;11(11):956. doi: 10.1038/s41419-020-03156-8. PubMed
Combined Inhibition of Galphaq and MEK Enhances Therapeutic Efficacy in Uveal Melanoma. Hitchman TD, Bayshtok G, Ceraudo E, Moore AR, Lee C, Jia R, Wang N, Pachai MR, Shoushtari AN, Francis JH, Guan Y, Chen J, Chang MT, Taylor BS, Sakmar TP, Huber T, Chi P, Chen Y. Clin Cancer Res. 2021 Mar 1;27(5):1476-1490. doi: 10.1158/1078-0432.CCR-20-2860. Epub 2020 Nov 23. PubMed
Breast tumor stiffness instructs bone metastasis via maintenance of mechanical conditioning. Watson AW, Grant AD, Parker SS, Hill S, Whalen MB, Chakrabarti J, Harman MW, Roman MR, Forte BL, Gowan CC, Castro-Portuguez R, Stolze LK, Franck C, Cusanovich DA, Zavros Y, Padi M, Romanoski CE, Mouneimne G. Cell Rep. 2021 Jun 29;35(13):109293. doi: 10.1016/j.celrep.2021.109293. PubMed

If you have published an article using this material, please email us at [email protected] to have your article added to this page.