HA GSK3 beta K85A pcDNA3 Citations (32)
Originally described in: Modulation of the glycogen synthase kinase-3 family by tyrosine phosphorylation.Hughes K, Nikolakaki E, Plyte SE, Totty NF, Woodgett JR EMBO J. 1993 Feb . 12(2):803-8. PubMed
Articles Citing HA GSK3 beta K85A pcDNA3
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| Glycogen synthase kinase 3beta is a novel regulator of high glucose- and high insulin-induced extracellular matrix protein synthesis in renal proximal tubular epithelial cells. Mariappan MM, Shetty M, Sataranatarajan K, Choudhury GG, Kasinath BS. J Biol Chem. 2008 Nov 7. 283(45):30566-75. PubMed |
| IFN-beta production by TLR4-stimulated innate immune cells is negatively regulated by GSK3-beta. Wang H, Garcia CA, Rehani K, Cekic C, Alard P, Kinane DF, Mitchell T, Martin M. J Immunol. 2008 Nov 15;181(10):6797-802. PubMed |
| TNF-induced activation of pulmonary microvessel endothelial cells: a role for GSK3beta. Johnson A. Am J Physiol Lung Cell Mol Physiol. 2009 Apr;296(4):L700-9. doi: 10.1152/ajplung.90566.2008. Epub 2009 Feb 13. PubMed |
Mcl-1 integrates the opposing actions of signaling pathways that mediate survival and apoptosis.
Morel C, Carlson SM, White FM, Davis RJ.
Mol Cell Biol. 2009 Jul . 29(14):3845-52.
PubMed
Associated Plasmids |
| Elevated levels of IL-1beta in Fanconi anaemia group A patients due to a constitutively active phosphoinositide 3-kinase-Akt pathway are capable of promoting tumour cell proliferation. Ibanez A, Rio P, Casado JA, Bueren JA, Fernandez-Luna JL, Pipaon C. Biochem J. 2009 Jul 29;422(1):161-70. doi: 10.1042/BJ20082118. PubMed |
| GSK3beta is a negative regulator of the transcriptional coactivator MAML1. Saint Just Ribeiro M, Hansson ML, Lindberg MJ, Popko-Scibor AE, Wallberg AE. Nucleic Acids Res. 2009 Nov;37(20):6691-700. doi: 10.1093/nar/gkp724. Epub 2009 Sep 8. PubMed |
| The role of glycogen synthase kinase 3 in regulating IFN-beta-mediated IL-10 production. Wang H, Brown J, Garcia CA, Tang Y, Benakanakere MR, Greenway T, Alard P, Kinane DF, Martin M. J Immunol. 2011 Jan 15;186(2):675-84. doi: 10.4049/jimmunol.1001473. Epub 2010 Dec 15. PubMed |
| The effects of oxygen tension and antiaging factor Klotho on Wnt signaling in nucleus pulposus cells. Hiyama A, Arai F, Sakai D, Yokoyama K, Mochida J. Arthritis Res Ther. 2012 May 2;14(3):R105. doi: 10.1186/ar3830. PubMed |
| ErbB2-dependent chemotaxis requires microtubule capture and stabilization coordinated by distinct signaling pathways. Benseddik K, Sen Nkwe N, Daou P, Verdier-Pinard P, Badache A. PLoS One. 2013;8(1):e55211. doi: 10.1371/journal.pone.0055211. Epub 2013 Jan 29. PubMed |
| Sprouty2, PTEN, and PP2A interact to regulate prostate cancer progression. Patel R, Gao M, Ahmad I, Fleming J, Singh LB, Rai TS, McKie AB, Seywright M, Barnetson RJ, Edwards J, Sansom OJ, Leung HY. J Clin Invest. 2013 Mar;123(3):1157-75. doi: 10.1172/JCI63672. Epub 2013 Feb 22. PubMed |
| Inositol hexakisphosphate kinase-1 regulates behavioral responses via GSK3 signaling pathways. Chakraborty A, Latapy C, Xu J, Snyder SH, Beaulieu JM. Mol Psychiatry. 2014 Mar;19(3):284-93. doi: 10.1038/mp.2013.21. Epub 2013 Feb 26. PubMed |
| Amyloid-beta oligomers induce tau-independent disruption of BDNF axonal transport via calcineurin activation in cultured hippocampal neurons. Ramser EM, Gan KJ, Decker H, Fan EY, Suzuki MM, Ferreira ST, Silverman MA. Mol Biol Cell. 2013 Aug;24(16):2494-505. doi: 10.1091/mbc.E12-12-0858. Epub 2013 Jun 19. PubMed |
| A low-density culture method of cerebellar granule neurons with paracrine support applicable for the study of neuronal morphogenesis. Kubota K, Seno T, Konishi Y. Brain Res. 2013 Nov 20;1539:15-23. doi: 10.1016/j.brainres.2013.09.046. Epub 2013 Oct 3. PubMed |
| Telomerase stimulates ribosomal DNA transcription under hyperproliferative conditions. Gonzalez OG, Assfalg R, Koch S, Schelling A, Meena JK, Kraus J, Lechel A, Katz SF, Benes V, Scharffetter-Kochanek K, Kestler HA, Gunes C, Iben S. Nat Commun. 2014 Aug 13;5:4599. doi: 10.1038/ncomms5599. PubMed |
| Amplified lipid rafts of malignant cells constitute a target for inhibition of aberrantly active NFAT and melanoma tumor growth by the aminobisphosphonate zoledronic acid. Levin-Gromiko U, Koshelev V, Kushnir P, Fedida-Metula S, Voronov E, Fishman D. Carcinogenesis. 2014 Nov;35(11):2555-66. doi: 10.1093/carcin/bgu178. Epub 2014 Aug 20. PubMed |
| GSK3beta-dependent phosphorylation alters DNA binding, transactivity and half-life of the transcription factor USF2. Horbach T, Chi TF, Gotz C, Sharma S, Juffer AH, Dimova EY, Kietzmann T. PLoS One. 2014 Sep 19;9(9):e107914. doi: 10.1371/journal.pone.0107914. eCollection 2014. PubMed |
| GSK-3beta Phosphorylation of Cytoplasmic Dynein Reduces Ndel1 Binding to Intermediate Chains and Alters Dynein Motility. Gao FJ, Hebbar S, Gao XA, Alexander M, Pandey JP, Walla MD, Cotham WE, King SJ, Smith DS. Traffic. 2015 May 22. doi: 10.1111/tra.12304. PubMed |
| N-Myc and STAT Interactor regulates autophagy and chemosensitivity in breast cancer cells. Metge BJ, Mitra A, Chen D, Shevde LA, Samant RS. Sci Rep. 2015 Jul 6;5:11995. doi: 10.1038/srep11995. PubMed |
| Stringent Control of NFE2L3 (Nuclear Factor, Erythroid 2-Like 3; NRF3) Protein Degradation by FBW7 (F-box/WD Repeat-containing Protein 7) and Glycogen Synthase Kinase 3 (GSK3). Kannan MB, Dodard-Friedman I, Blank V. J Biol Chem. 2015 Oct 23;290(43):26292-302. doi: 10.1074/jbc.M115.666446. Epub 2015 Aug 25. PubMed |
| Glycogen synthase kinase-3beta modulation of glucocorticoid responsiveness in COPD. Ngkelo A, Hoffmann RF, Durham AL, Marwick JA, Brandenburg SM, de Bruin HG, Jonker MR, Rossios C, Tsitsiou E, Caramori G, Contoli M, Casolari P, Monaco F, Ando F, Speciale G, Kilty I, Chung KF, Papi A, Lindsay MA, Ten Hacken NH, van den Berge M, Timens W, Barnes PJ, van Oosterhout AJ, Adcock IM, Kirkham PA, Heijink IH. Am J Physiol Lung Cell Mol Physiol. 2015 Nov 15;309(10):L1112-23. doi: 10.1152/ajplung.00077.2015. Epub 2015 Aug 28. PubMed |
| GSK3beta regulates AKT-induced central nervous system axon regeneration via an eIF2Bepsilon-dependent, mTORC1-independent pathway. Guo X, Snider WD, Chen B. Elife. 2016 Mar 14;5:e11903. doi: 10.7554/eLife.11903. PubMed |
| HGF alleviates high glucose-induced injury in podocytes by GSK3beta inhibition and autophagy restoration. Zhang C, Hou B, Yu S, Chen Q, Zhang N, Li H. Biochim Biophys Acta. 2016 Nov;1863(11):2690-2699. doi: 10.1016/j.bbamcr.2016.08.004. Epub 2016 Aug 12. PubMed |
| Biliverdin Reductase A Attenuates Hepatic Steatosis by Inhibition of Glycogen Synthase Kinase (GSK) 3beta Phosphorylation of Serine 73 of Peroxisome Proliferator-activated Receptor (PPAR) alpha. Hinds TD Jr, Burns KA, Hosick PA, McBeth L, Nestor-Kalinoski A, Drummond HA, AlAmodi AA, Hankins MW, Vanden Heuvel JP, Stec DE. J Biol Chem. 2016 Nov 25;291(48):25179-25191. Epub 2016 Oct 10. PubMed |
| GSK3alpha and GSK3beta Phosphorylate Arc and Regulate its Degradation. Gozdz A, Nikolaienko O, Urbanska M, Cymerman IA, Sitkiewicz E, Blazejczyk M, Dadlez M, Bramham CR, Jaworski J. Front Mol Neurosci. 2017 Jun 16;10:192. doi: 10.3389/fnmol.2017.00192. eCollection 2017. PubMed |
| GSK3beta modulates NF-kappaB activation and RelB degradation through site-specific phosphorylation of BCL10. Abd-Ellah A, Voogdt C, Krappmann D, Moller P, Marienfeld RB. Sci Rep. 2018 Jan 22;8(1):1352. doi: 10.1038/s41598-018-19822-z. PubMed |
| Modulation of GSK3beta autoinhibition by Thr-7 and Thr-8. Tong Y, Park S, Wu D, Harris TE, Moskaluk CA, Brautigan DL, Fu Z. FEBS Lett. 2018 Feb;592(4):537-546. doi: 10.1002/1873-3468.12990. Epub 2018 Feb 8. PubMed |
| GSK3 is a negative regulator of the thermogenic program in brown adipocytes. Markussen LK, Winther S, Wicksteed B, Hansen JB. Sci Rep. 2018 Feb 22;8(1):3469. doi: 10.1038/s41598-018-21795-y. PubMed |
| SIRT2 deacetylase regulates the activity of GSK3 isoforms independent of inhibitory phosphorylation. Sarikhani M, Mishra S, Maity S, Kotyada C, Wolfgeher D, Gupta MP, Singh M, Sundaresan NR. Elife. 2018 Mar 5;7. pii: 32952. doi: 10.7554/eLife.32952. PubMed |
| Glycogen synthase kinase-3ss supports serotonin transporter function and trafficking in a phosphorylation-dependent manner. Ragu Varman D, Jayanthi LD, Ramamoorthy S. J Neurochem. 2021 Feb;156(4):445-464. doi: 10.1111/jnc.15152. Epub 2020 Sep 7. PubMed |
| HGF protected against diabetic nephropathy via autophagy-lysosome pathway in podocyte by modulating PI3K/Akt-GSK3beta-TFEB axis. Hou B, Li Y, Li X, Zhang C, Zhao Z, Chen Q, Zhang N, Li H. Cell Signal. 2020 Nov;75:109744. doi: 10.1016/j.cellsig.2020.109744. Epub 2020 Aug 19. PubMed |
| Tau phosphorylation by glycogen synthase kinase 3beta modulates enzyme acetylcholinesterase expression. Cortes-Gomez MA, Llorens-Alvarez E, Alom J, Del Ser T, Avila J, Saez-Valero J, Garcia-Ayllon MS. J Neurochem. 2020 Sep 21. doi: 10.1111/jnc.15189. PubMed |
| Endonuclease G promotes autophagy by suppressing mTOR signaling and activating the DNA damage response. Wang W, Li J, Tan J, Wang M, Yang J, Zhang ZM, Li C, Basnakian AG, Tang HW, Perrimon N, Zhou Q. Nat Commun. 2021 Jan 20;12(1):476. doi: 10.1038/s41467-020-20780-2. PubMed |
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