HA GSK3 beta wt pcDNA3 Citations (51)
Originally described in: Glycogen synthase kinase-3 and dorsoventral patterning in Xenopus embryos.He X, Saint-Jeannet JP, Woodgett JR, Varmus HE, Dawid IB Nature. 1995 Apr 13. 374(6523):617-22. PubMed Journal
Articles Citing HA GSK3 beta wt pcDNA3
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| TNF-induced activation of pulmonary microvessel endothelial cells: a role for GSK3beta. Johnson A. Am J Physiol Lung Cell Mol Physiol. 2009 Apr;296(4):L700-9. doi: 10.1152/ajplung.90566.2008. Epub 2009 Feb 13. PubMed |
Mcl-1 integrates the opposing actions of signaling pathways that mediate survival and apoptosis.
Morel C, Carlson SM, White FM, Davis RJ.
Mol Cell Biol. 2009 Jul . 29(14):3845-52.
PubMed
Associated Plasmids |
| Glycogen synthase kinase 3 beta (GSK3beta) phosphorylates the RNAase III enzyme Drosha at S300 and S302. Tang X, Li M, Tucker L, Ramratnam B. PLoS One. 2011;6(6):e20391. doi: 10.1371/journal.pone.0020391. Epub 2011 Jun 3. PubMed |
| Effects of a glycogen synthase kinase-3beta inhibitor (LiCl) on c-myc protein in intervertebral disc cells. Hiyama A, Sakai D, Arai F, Nakajima D, Yokoyama K, Mochida J. J Cell Biochem. 2011 Oct;112(10):2974-86. doi: 10.1002/jcb.23217. PubMed |
| Akt-mediated proinflammatory response of mononuclear phagocytes infected with Burkholderia cenocepacia occurs by a novel GSK3beta-dependent, IkappaB kinase-independent mechanism. Cremer TJ, Shah P, Cormet-Boyaka E, Valvano MA, Butchar JP, Tridandapani S. J Immunol. 2011 Jul 15;187(2):635-43. doi: 10.4049/jimmunol.1003034. Epub 2011 Jun 22. PubMed |
| Phosphatidylinositol 3'-kinase, mTOR, and glycogen synthase kinase-3beta mediated regulation of p21 in human urothelial carcinoma cells. Yohn NL, Bingaman CN, DuMont AL, Yoo LI. BMC Urol. 2011 Aug 24;11:19. doi: 10.1186/1471-2490-11-19. PubMed |
| DNAJB6 chaperones PP2A mediated dephosphorylation of GSK3beta to downregulate beta-catenin transcription target, osteopontin. Mitra A, Menezes ME, Pannell LK, Mulekar MS, Honkanen RE, Shevde LA, Samant RS. Oncogene. 2012 Oct 11;31(41):4472-83. doi: 10.1038/onc.2011.623. Epub 2012 Jan 23. PubMed |
| GSK-3 promotes cell survival, growth, and PAX3 levels in human melanoma cells. Kubic JD, Mascarenhas JB, Iizuka T, Wolfgeher D, Lang D. Mol Cancer Res. 2012 Aug;10(8):1065-76. doi: 10.1158/1541-7786.MCR-11-0387. Epub 2012 Jun 7. PubMed |
| Hypothalamic glycogen synthase kinase 3beta has a central role in the regulation of food intake and glucose metabolism. Benzler J, Ganjam GK, Kruger M, Pinkenburg O, Kutschke M, Stohr S, Steger J, Koch CE, Olkrug R, Schwartz MW, Shepherd PR, Grattan DR, Tups A. Biochem J. 2012 Oct 1;447(1):175-84. doi: 10.1042/BJ20120834. PubMed |
| ARTD10 substrate identification on protein microarrays: regulation of GSK3beta by mono-ADP-ribosylation. Feijs KL, Kleine H, Braczynski A, Forst AH, Herzog N, Verheugd P, Linzen U, Kremmer E, Luscher B. Cell Commun Signal. 2013 Jan 19;11(1):5. doi: 10.1186/1478-811X-11-5. PubMed |
| Klebsiella pneumoniae targets an EGF receptor-dependent pathway to subvert inflammation. Frank CG, Reguerio V, Rother M, Moranta D, Maeurer AP, Garmendia J, Meyer TF, Bengoechea JA. Cell Microbiol. 2013 Jul;15(7):1212-33. doi: 10.1111/cmi.12110. Epub 2013 Feb 17. PubMed |
| Inositol hexakisphosphate kinase-1 regulates behavioral responses via GSK3 signaling pathways. Chakraborty A, Latapy C, Xu J, Snyder SH, Beaulieu JM. Mol Psychiatry. 2014 Mar;19(3):284-93. doi: 10.1038/mp.2013.21. Epub 2013 Feb 26. PubMed |
| Glucocorticoid receptor beta regulates injury-mediated astrocyte activation and contributes to glioma pathogenesis via modulation of beta-catenin/TCF transcriptional activity. Yin Y, Zhang X, Li Z, Deng L, Jiao G, Zhang B, Xie P, Mu H, Qiao W, Zou J. Neurobiol Dis. 2013 Nov;59:165-76. doi: 10.1016/j.nbd.2013.07.013. Epub 2013 Jul 30. PubMed |
| A low-density culture method of cerebellar granule neurons with paracrine support applicable for the study of neuronal morphogenesis. Kubota K, Seno T, Konishi Y. Brain Res. 2013 Nov 20;1539:15-23. doi: 10.1016/j.brainres.2013.09.046. Epub 2013 Oct 3. PubMed |
| Constitutive somatostatin receptor subtype-3 signaling suppresses growth hormone synthesis. Eigler T, Ben-Shlomo A, Zhou C, Khalafi R, Ren SG, Melmed S. Mol Endocrinol. 2014 Apr;28(4):554-64. doi: 10.1210/me.2013-1327. Epub 2014 Feb 25. PubMed |
| Helicobacter pylori CagA promotes Snail-mediated epithelial-mesenchymal transition by reducing GSK-3 activity. Lee DG, Kim HS, Lee YS, Kim S, Cha SY, Ota I, Kim NH, Cha YH, Yang DH, Lee Y, Park GJ, Yook JI, Lee YC. Nat Commun. 2014 Jul 23;5:4423. doi: 10.1038/ncomms5423. PubMed |
| GSK3beta-dependent phosphorylation alters DNA binding, transactivity and half-life of the transcription factor USF2. Horbach T, Chi TF, Gotz C, Sharma S, Juffer AH, Dimova EY, Kietzmann T. PLoS One. 2014 Sep 19;9(9):e107914. doi: 10.1371/journal.pone.0107914. eCollection 2014. PubMed |
| Sulforaphane attenuation of experimental diabetic nephropathy involves GSK-3 beta/Fyn/Nrf2 signaling pathway. Shang G, Tang X, Gao P, Guo F, Liu H, Zhao Z, Chen Q, Jiang T, Zhang N, Li H. J Nutr Biochem. 2015 Jun;26(6):596-606. doi: 10.1016/j.jnutbio.2014.12.008. Epub 2015 Feb 12. PubMed |
| Stringent Control of NFE2L3 (Nuclear Factor, Erythroid 2-Like 3; NRF3) Protein Degradation by FBW7 (F-box/WD Repeat-containing Protein 7) and Glycogen Synthase Kinase 3 (GSK3). Kannan MB, Dodard-Friedman I, Blank V. J Biol Chem. 2015 Oct 23;290(43):26292-302. doi: 10.1074/jbc.M115.666446. Epub 2015 Aug 25. PubMed |
| GSK-3beta is positively regulated by PKCzeta -mediated phosphorylation induced by Wnt agonists. Tejeda-Munoz N, Gonzalez-Aguilar H, Santoyo-Ramos P, Castaneda-Patlan MC, Robles-Flores M. Mol Cell Biol. 2015 Dec 28. pii: MCB.00828-15. PubMed |
| Xanthatin anti-tumor cytotoxicity is mediated via glycogen synthase kinase-3beta and beta-catenin. Tao L, Sheng X, Zhang L, Li W, Wei Z, Zhu P, Zhang F, Wang A, Woodgett JR, Lu Y. Biochem Pharmacol. 2016 Jun 16. pii: S0006-2952(16)30135-6. doi: 10.1016/j.bcp.2016.06.009. PubMed |
| Gsk3beta and Tomm20 are substrates of the SCFFbxo7/PARK15 ubiquitin ligase associated with Parkinson's disease. Teixeira FR, Randle SJ, Patel SP, Mevissen TE, Zenkeviciute G, Koide T, Komander D, Laman H. Biochem J. 2016 Oct 15;473(20):3563-3580. Epub 2016 Aug 8. PubMed |
| HGF alleviates high glucose-induced injury in podocytes by GSK3beta inhibition and autophagy restoration. Zhang C, Hou B, Yu S, Chen Q, Zhang N, Li H. Biochim Biophys Acta. 2016 Nov;1863(11):2690-2699. doi: 10.1016/j.bbamcr.2016.08.004. Epub 2016 Aug 12. PubMed |
SOX9 is targeted for proteasomal degradation by the E3 ligase FBW7 in response to DNA damage.
Hong X, Liu W, Song R, Shah JJ, Feng X, Tsang CK, Morgan KM, Bunting SF, Inuzuka H, Zheng XF, Shen Z, Sabaawy HE, Liu L, Pine SR.
Nucleic Acids Res. 2016 Oct 14;44(18):8855-8869. Epub 2016 Aug 26.
PubMed
Associated Plasmids |
| Extensive nuclear sphere generation in the human Alzheimer's brain. Kolbe K, Bukhari H, Loosse C, Leonhardt G, Glotzbach A, Pawlas M, Hess K, Theiss C, Muller T. Neurobiol Aging. 2016 Dec;48:103-113. doi: 10.1016/j.neurobiolaging.2016.08.016. Epub 2016 Aug 26. PubMed |
| Leishmania donovani inhibits macrophage apoptosis and pro-inflammatory response through AKT-mediated regulation of beta-catenin and FOXO-1. Gupta P, Srivastav S, Saha S, Das PK, Ukil A. Cell Death Differ. 2016 Nov 1;23(11):1815-1826. doi: 10.1038/cdd.2016.101. Epub 2016 Sep 23. PubMed |
| Biliverdin Reductase A Attenuates Hepatic Steatosis by Inhibition of Glycogen Synthase Kinase (GSK) 3beta Phosphorylation of Serine 73 of Peroxisome Proliferator-activated Receptor (PPAR) alpha. Hinds TD Jr, Burns KA, Hosick PA, McBeth L, Nestor-Kalinoski A, Drummond HA, AlAmodi AA, Hankins MW, Vanden Heuvel JP, Stec DE. J Biol Chem. 2016 Nov 25;291(48):25179-25191. Epub 2016 Oct 10. PubMed |
| Glycogen Synthase Kinase 3 (GSK-3)-mediated Phosphorylation of Uracil N-Glycosylase 2 (UNG2) Facilitates the Repair of Floxuridine-induced DNA Lesions and Promotes Cell Survival. Baehr CA, Huntoon CJ, Hoang SM, Jerde CR, Karnitz LM. J Biol Chem. 2016 Dec 23;291(52):26875-26885. doi: 10.1074/jbc.M116.746081. Epub 2016 Nov 14. PubMed |
| Pathogenic LRRK2 variants are gain-of-function mutations that enhance LRRK2-mediated repression of beta-catenin signaling. Berwick DC, Javaheri B, Wetzel A, Hopkinson M, Nixon-Abell J, Granno S, Pitsillides AA, Harvey K. Mol Neurodegener. 2017 Jan 19;12(1):9. doi: 10.1186/s13024-017-0153-4. PubMed |
| NONO ubiquitination is mediated by FBW7 and GSK3 beta via a degron lost upon chromosomal rearrangement in cancer. Alfano L, Caporaso A, Altieri A, Costa C, Forte IM, Iannuzzi CA, Barone D, Esposito L, Giordano A, Pentimalli F. J Cell Physiol. 2018 May;233(5):4338-4344. doi: 10.1002/jcp.26269. Epub 2017 Dec 29. PubMed |
| Clathrin Assembly Defines the Onset and Geometry of Cortical Patterning. Yang Y, Xiong D, Pipathsouk A, Weiner OD, Wu M. Dev Cell. 2017 Nov 20;43(4):507-521.e4. doi: 10.1016/j.devcel.2017.10.028. PubMed |
| GSK3beta modulates NF-kappaB activation and RelB degradation through site-specific phosphorylation of BCL10. Abd-Ellah A, Voogdt C, Krappmann D, Moller P, Marienfeld RB. Sci Rep. 2018 Jan 22;8(1):1352. doi: 10.1038/s41598-018-19822-z. PubMed |
| Modulation of GSK3beta autoinhibition by Thr-7 and Thr-8. Tong Y, Park S, Wu D, Harris TE, Moskaluk CA, Brautigan DL, Fu Z. FEBS Lett. 2018 Feb;592(4):537-546. doi: 10.1002/1873-3468.12990. Epub 2018 Feb 8. PubMed |
| SIRT2 deacetylase regulates the activity of GSK3 isoforms independent of inhibitory phosphorylation. Sarikhani M, Mishra S, Maity S, Kotyada C, Wolfgeher D, Gupta MP, Singh M, Sundaresan NR. Elife. 2018 Mar 5;7. pii: 32952. doi: 10.7554/eLife.32952. PubMed |
| Brain ischemic preconditioning protects against ischemic injury and preserves the blood-brain barrier via oxidative signaling and Nrf2 activation. Yang T, Sun Y, Mao L, Zhang M, Li Q, Zhang L, Shi Y, Leak RK, Chen J, Zhang F. Redox Biol. 2018 Jul;17:323-337. doi: 10.1016/j.redox.2018.05.001. Epub 2018 May 6. PubMed |
| Modeling Late-Onset Sporadic Alzheimer's Disease through BMI1 Deficiency. Flamier A, El Hajjar J, Adjaye J, Fernandes KJ, Abdouh M, Bernier G. Cell Rep. 2018 May 29;23(9):2653-2666. doi: 10.1016/j.celrep.2018.04.097. PubMed |
| AMPK/FIS1-Mediated Mitophagy Is Required for Self-Renewal of Human AML Stem Cells. Pei S, Minhajuddin M, Adane B, Khan N, Stevens BM, Mack SC, Lai S, Rich JN, Inguva A, Shannon KM, Kim H, Tan AC, Myers JR, Ashton JM, Neff T, Pollyea DA, Smith CA, Jordan CT. Cell Stem Cell. 2018 Jul 5;23(1):86-100.e6. doi: 10.1016/j.stem.2018.05.021. Epub 2018 Jun 14. PubMed |
| A genetic model to study O-GlcNAc cycling in immortalized mouse embryonic fibroblasts. St Amand MM, Bond MR, Riedy J, Comly M, Shiloach J, Hanover JA. J Biol Chem. 2018 Aug 31;293(35):13673-13681. doi: 10.1074/jbc.RA118.004059. Epub 2018 Jun 28. PubMed |
| Insulin induces phosphorylation of pyruvate dehydrogenase through RhoA activation pathway in HepG2 cells. Islam R, Kim JG, Park Y, Cho JY, Cap KC, Kho AR, Chung WS, Suh SW, Park JB. FASEB J. 2019 Feb;33(2):2072-2083. doi: 10.1096/fj.201800917R. Epub 2018 Sep 18. PubMed |
| Glycogen Synthase Kinase 3beta Enhances Hepatitis C Virus Replication by Supporting miR-122. Saleh M, Ruschenbaum S, Welsch C, Zeuzem S, Moradpour D, Gouttenoire J, Lange CM. Front Microbiol. 2018 Nov 27;9:2949. doi: 10.3389/fmicb.2018.02949. eCollection 2018. PubMed |
| PKCgamma promotes axonal remodeling in the cortico-spinal tract via GSK3beta/beta-catenin signaling after traumatic brain injury. Zhang B, Li Z, Zhang R, Hu Y, Jiang Y, Cao T, Wang J, Gong L, Ji L, Mu H, Yang X, Dai Y, Jiang C, Yin Y, Zou J. Sci Rep. 2019 Nov 19;9(1):17078. doi: 10.1038/s41598-019-53225-y. PubMed |
| Glycogen Synthase Kinase-3 modulates alpha1A-adrenergic receptor action and regulation. Alcantara-Hernandez R, Carmona-Rosas G, Hernandez-Espinosa DA, Garcia-Sainz JA. Eur J Cell Biol. 2020 Apr;99(2-3):151072. doi: 10.1016/j.ejcb.2020.151072. Epub 2020 Feb 22. PubMed |
| JAK3 restrains inflammatory responses and protects against periodontal disease through Wnt3a signaling. Lu L, Yakoumatos L, Ren J, Duan X, Zhou H, Gu Z, Mohammed M, Uriarte SM, Liang S, Scott DA, Lamont RJ, Wang H. FASEB J. 2020 May 20. doi: 10.1096/fj.201902697RR. PubMed |
| Histone Deacetylase 9 Activates IKK to Regulate Atherosclerotic Plaque Vulnerability. Asare Y, Campbell-James TA, Bokov Y, Yu LL, Prestel M, El Bounkari O, Roth S, Megens RTA, Straub T, Thomas K, Yan G, Schneider M, Ziesch N, Tiedt S, Silvestre-Roig C, Braster Q, Huang Y, Schneider M, Malik R, Haffner C, Liesz A, Soehnlein O, Bernhagen J, Dichgans M. Circ Res. 2020 Aug 28;127(6):811-823. doi: 10.1161/CIRCRESAHA.120.316743. Epub 2020 Jun 17. PubMed |
| Glycogen synthase kinase-3ss supports serotonin transporter function and trafficking in a phosphorylation-dependent manner. Ragu Varman D, Jayanthi LD, Ramamoorthy S. J Neurochem. 2021 Feb;156(4):445-464. doi: 10.1111/jnc.15152. Epub 2020 Sep 7. PubMed |
| HGF protected against diabetic nephropathy via autophagy-lysosome pathway in podocyte by modulating PI3K/Akt-GSK3beta-TFEB axis. Hou B, Li Y, Li X, Zhang C, Zhao Z, Chen Q, Zhang N, Li H. Cell Signal. 2020 Nov;75:109744. doi: 10.1016/j.cellsig.2020.109744. Epub 2020 Aug 19. PubMed |
| Klebsiella pneumoniae Reduces SUMOylation To Limit Host Defense Responses. Sa-Pessoa J, Przybyszewska K, Vasconcelos FN, Dumigan A, Frank CG, Hobley L, Bengoechea JA. mBio. 2020 Sep 29;11(5). pii: mBio.01733-20. doi: 10.1128/mBio.01733-20. PubMed |
| Hydrogen sulfide is neuroprotective in Alzheimer's disease by sulfhydrating GSK3beta and inhibiting Tau hyperphosphorylation. Giovinazzo D, Bursac B, Sbodio JI, Nalluru S, Vignane T, Snowman AM, Albacarys LM, Sedlak TW, Torregrossa R, Whiteman M, Filipovic MR, Snyder SH, Paul BD. Proc Natl Acad Sci U S A. 2021 Jan 26;118(4). pii: 2017225118. doi: 10.1073/pnas.2017225118. PubMed |
| Endonuclease G promotes autophagy by suppressing mTOR signaling and activating the DNA damage response. Wang W, Li J, Tan J, Wang M, Yang J, Zhang ZM, Li C, Basnakian AG, Tang HW, Perrimon N, Zhou Q. Nat Commun. 2021 Jan 20;12(1):476. doi: 10.1038/s41467-020-20780-2. PubMed |
| Deficiency of Lipin2 Results in Enhanced NF-kappaB Signaling and Osteoclast Formation in RAW-D Murine Macrophages. Watahiki A, Hoshikawa S, Chiba M, Egusa H, Fukumoto S, Inuzuka H. Int J Mol Sci. 2021 Mar 12;22(6). pii: ijms22062893. doi: 10.3390/ijms22062893. PubMed |
| Analysis of Tumor-Associated AXIN1 Missense Mutations Identifies Variants That Activate beta-Catenin Signaling. Zhang R, Li S, Schippers K, Li Y, Eimers B, Lavrijsen M, Wang L, Cui G, Chen X, Peppelenbosch MP, Lebbink JHG, Smits R. Cancer Res. 2024 May 2;84(9):1443-1459. doi: 10.1158/0008-5472.CAN-23-2268. PubMed |
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