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ABE8e Citations (28)

Originally described in: Phage-assisted evolution of an adenine base editor with improved Cas domain compatibility and activity.
Richter MF, Zhao KT, Eton E, Lapinaite A, Newby GA, Thuronyi BW, Wilson C, Koblan LW, Zeng J, Bauer DE, Doudna JA, Liu DR Nat Biotechnol. 2020 Jul;38(7):883-891. doi: 10.1038/s41587-020-0453-z. Epub 2020 Mar 16. PubMed Journal

Articles Citing ABE8e

Articles
Predicting base editing outcomes with an attention-based deep learning algorithm trained on high-throughput target library screens. Marquart KF, Allam A, Janjuha S, Sintsova A, Villiger L, Frey N, Krauthammer M, Schwank G. Nat Commun. 2021 Aug 25;12(1):5114. doi: 10.1038/s41467-021-25375-z. PubMed
Replacing the SpCas9 HNH domain by deaminases generates compact base editors with an alternative targeting scope. Villiger L, Schmidheini L, Mathis N, Rothgangl T, Marquart K, Schwank G. Mol Ther Nucleic Acids. 2021 Aug 26;26:502-510. doi: 10.1016/j.omtn.2021.08.025. eCollection 2021 Dec 3. PubMed

Associated Plasmids
Editing Properties of Base Editors with SpCas9-NG in Discarded Human Tripronuclear Zygotes. Liu X, Zhou X, Li G, Huang S, Sun W, Sun Q, Li L, Huang X, Liu J, Wang L. CRISPR J. 2021 Oct;4(5):710-727. doi: 10.1089/crispr.2021.0036. PubMed
Comprehensive analysis of prime editing outcomes in human embryonic stem cells. Habib O, Habib G, Hwang GH, Bae S. Nucleic Acids Res. 2022 Jan 25;50(2):1187-1197. doi: 10.1093/nar/gkab1295. PubMed
Inhibition of base editors with anti-deaminases derived from viruses. Liu Z, Chen S, Lai L, Li Z. Nat Commun. 2022 Feb 1;13(1):597. doi: 10.1038/s41467-022-28300-0. PubMed
Highly efficient A-to-G base editing by ABE8.17 in rabbits. Zhao D, Qian Y, Li J, Li Z, Lai L. Mol Ther Nucleic Acids. 2022 Jan 28;27:1156-1163. doi: 10.1016/j.omtn.2022.01.019. eCollection 2022 Mar 8. PubMed
Predicting base editing outcomes using position-specific sequence determinants. Pallaseni A, Peets EM, Koeppel J, Weller J, Vanderstichele T, Ho UL, Crepaldi L, van Leeuwen J, Allen F, Parts L. Nucleic Acids Res. 2022 Apr 8;50(6):3551-3564. doi: 10.1093/nar/gkac161. PubMed
Precise in vivo functional analysis of DNA variants with base editing using ACEofBASEs target prediction. Cornean A, Gierten J, Welz B, Mateo JL, Thumberger T, Wittbrodt J. Elife. 2022 Apr 4;11:e72124. doi: 10.7554/eLife.72124. PubMed
Efficient multinucleotide deletions using deaminase-Cas9 fusions in human cells. Chen S, Liu Z, Yu H, Lai L, Li Z. J Genet Genomics. 2022 Oct;49(10):927-933. doi: 10.1016/j.jgg.2022.03.007. Epub 2022 Apr 11. PubMed
Frequency and mechanisms of LINE-1 retrotransposon insertions at CRISPR/Cas9 sites. Tao J, Wang Q, Mendez-Dorantes C, Burns KH, Chiarle R. Nat Commun. 2022 Jun 27;13(1):3685. doi: 10.1038/s41467-022-31322-3. PubMed
De novo PAM generation to reach initially inaccessible target sites for base editing. Pakari K, Wittbrodt J, Thumberger T. Development. 2023 Jan 15;150(2):dev201115. doi: 10.1242/dev.201115. Epub 2023 Jan 23. PubMed
Targeted dual base editing with Campylobacter jejuni Cas9 by single AAV-mediated delivery. Kweon J, Jang AH, Kwon E, Kim U, Shin HR, See J, Jang G, Lee C, Koo T, Kim S, Kim Y. Exp Mol Med. 2023 Feb;55(2):377-384. doi: 10.1038/s12276-023-00938-w. Epub 2023 Feb 1. PubMed
A highly specific CRISPR-Cas12j nuclease enables allele-specific genome editing. Wang Y, Qi T, Liu J, Yang Y, Wang Z, Wang Y, Wang T, Li M, Li M, Lu D, Chang ACY, Yang L, Gao S, Wang Y, Lan F. Sci Adv. 2023 Feb 10;9(6):eabo6405. doi: 10.1126/sciadv.abo6405. Epub 2023 Feb 10. PubMed

Associated Plasmids
Base editing correction of hypertrophic cardiomyopathy in human cardiomyocytes and humanized mice. Chai AC, Cui M, Chemello F, Li H, Chen K, Tan W, Atmanli A, McAnally JR, Zhang Y, Xu L, Liu N, Bassel-Duby R, Olson EN. Nat Med. 2023 Feb;29(2):401-411. doi: 10.1038/s41591-022-02176-5. Epub 2023 Feb 16. PubMed
Transition Substitution of Desired Bases in Human Pluripotent Stem Cells with Base Editors: A Step-by-Step Guide. Park JC, Kim KT, Jang HK, Cha HJ. Int J Stem Cells. 2023 May 30;16(2):234-243. doi: 10.15283/ijsc22171. Epub 2023 Feb 28. PubMed
Improving adenine and dual base editors through introduction of TadA-8e and Rad51DBD. Xue N, Liu X, Zhang D, Wu Y, Zhong Y, Wang J, Fan W, Jiang H, Zhu B, Ge X, Gonzalez RVL, Chen L, Zhang S, She P, Zhong Z, Sun J, Chen X, Wang L, Gu Z, Zhu P, Liu M, Li D, Zhong TP, Zhang X. Nat Commun. 2023 Mar 3;14(1):1224. doi: 10.1038/s41467-023-36887-1. PubMed
PAM-Flexible Genome Editing with an Engineered Chimeric Cas9. Koseki S, Hong L, Yudistyra V, Stan T, Tysinger E, Silverstein R, Kramme C, Amrani N, Savic N, Pacesa M, Rodriguez TS, Ponnapati M, Jacobson J, Church G, Truant R, Jinek M, Kleinstiver B, Sontheimer E, Chatterjee P. Res Sq. 2023 Mar 7:rs.3.rs-2625838. doi: 10.21203/rs.3.rs-2625838/v1. Preprint. PubMed

Associated Plasmids
Highly Efficient A-to-G Editing in PFFs via Multiple ABEs. Jing Q, Liu W, Jiang H, Liao Y, Yang Q, Xing Y. Genes (Basel). 2023 Apr 13;14(4):908. doi: 10.3390/genes14040908. PubMed
Single-swap editing for the correction of common Duchenne muscular dystrophy mutations. Chai AC, Chemello F, Li H, Nishiyama T, Chen K, Zhang Y, Sanchez-Ortiz E, Alomar A, Xu L, Liu N, Bassel-Duby R, Olson EN. Mol Ther Nucleic Acids. 2023 Apr 19;32:522-535. doi: 10.1016/j.omtn.2023.04.009. eCollection 2023 Jun 13. PubMed
Striated muscle-specific base editing enables correction of mutations causing dilated cardiomyopathy. Grosch M, Schraft L, Chan A, Kuchenhoff L, Rapti K, Ferreira AM, Kornienko J, Li S, Radke MH, Kramer C, Clauder-Munster S, Perlas E, Backs J, Gotthardt M, Dieterich C, van den Hoogenhof MMG, Grimm D, Steinmetz LM. Nat Commun. 2023 Jun 22;14(1):3714. doi: 10.1038/s41467-023-39352-1. PubMed
A new compact adenine base editor generated through deletion of HNH and REC2 domain of SpCas9. Qian Y, Wang D, Niu W, Zhao D, Li J, Liu Z, Gao X, Han Y, Lai L, Li Z. BMC Biol. 2023 Jul 11;21(1):155. doi: 10.1186/s12915-023-01644-9. PubMed
A split and inducible adenine base editor for precise in vivo base editing. Zeng H, Yuan Q, Peng F, Ma D, Lingineni A, Chee K, Gilberd P, Osikpa EC, Sun Z, Gao X. Nat Commun. 2023 Sep 11;14(1):5573. doi: 10.1038/s41467-023-41331-5. PubMed

Associated Plasmids
PAM-flexible genome editing with an engineered chimeric Cas9. Zhao L, Koseki SRT, Silverstein RA, Amrani N, Peng C, Kramme C, Savic N, Pacesa M, Rodriguez TC, Stan T, Tysinger E, Hong L, Yudistyra V, Ponnapati MR, Jacobson JM, Church GM, Jakimo N, Truant R, Jinek M, Kleinstiver BP, Sontheimer EJ, Chatterjee P. Nat Commun. 2023 Oct 4;14(1):6175. doi: 10.1038/s41467-023-41829-y. PubMed

Associated Plasmids
Decreasing predictable DNA off-target effects and narrowing editing windows of adenine base editors by fusing human Rad18 protein variant. Wang Z, Yuan H, Yang L, Ma L, Zhang Y, Deng J, Li X, Xiao W, Li Z, Qiu J, Ouyang H, Pang D. Int J Biol Macromol. 2023 Dec 31;253(Pt 7):127418. doi: 10.1016/j.ijbiomac.2023.127418. Epub 2023 Oct 16. PubMed
Engineered domain-inlaid Nme2Cas9 adenine base editors with increased on-target DNA editing and targeting scope. Zhao D, Gao X, Zhou J, Li J, Qian Y, Wang D, Niu W, Zhang T, Hu M, Xiong H, Lai L, Li Z. BMC Biol. 2023 Nov 9;21(1):250. doi: 10.1186/s12915-023-01754-4. PubMed
Efficient gene editing in induced pluripotent stem cells enabled by an inducible adenine base editor with tunable expression. Nandy K, Babu D, Rani S, Joshi G, Ijee S, George A, Palani D, Premkumar C, Rajesh P, Vijayanand S, David E, Murugesan M, Velayudhan SR. Sci Rep. 2023 Dec 11;13(1):21953. doi: 10.1038/s41598-023-42174-2. PubMed
Engineering TALE-linked deaminases to facilitate precision adenine base editing in mitochondrial DNA. Cho SI, Lim K, Hong S, Lee J, Kim A, Lim CJ, Ryou S, Lee JM, Mok YG, Chung E, Kim S, Han S, Cho SM, Kim J, Kim EK, Nam KH, Oh Y, Choi M, An TH, Oh KJ, Lee S, Lee H, Kim JS. Cell. 2024 Jan 4;187(1):95-109.e26. doi: 10.1016/j.cell.2023.11.035. PubMed

Associated Plasmids
Genetic and functional correction of argininosuccinate lyase deficiency using CRISPR adenine base editors. Jalil S, Keskinen T, Juutila J, Sartori Maldonado R, Euro L, Suomalainen A, Lapatto R, Kuuluvainen E, Hietakangas V, Otonkoski T, Hyvonen ME, Wartiovaara K. Am J Hum Genet. 2024 Apr 4;111(4):714-728. doi: 10.1016/j.ajhg.2024.03.004. PubMed

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