SIRT3 Flag Citations (26)
Originally described in: The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase.North BJ, Marshall BL, Borra MT, Denu JM, Verdin E Mol Cell. 2003 Feb . 11(2):437-44. PubMed Journal
Articles Citing SIRT3 Flag
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| Metformin reduces hepatic expression of SIRT3, the mitochondrial deacetylase controlling energy metabolism. Buler M, Aatsinki SM, Izzi V, Hakkola J. PLoS One. 2012;7(11):e49863. doi: 10.1371/journal.pone.0049863. Epub 2012 Nov 16. PubMed |
| The ubiquitin ligase CHIP prevents SirT6 degradation through noncanonical ubiquitination. Ronnebaum SM, Wu Y, McDonough H, Patterson C. Mol Cell Biol. 2013 Nov;33(22):4461-72. doi: 10.1128/MCB.00480-13. Epub 2013 Sep 16. PubMed |
| SIRT5 is under the control of PGC-1alpha and AMPK and is involved in regulation of mitochondrial energy metabolism. Buler M, Aatsinki SM, Izzi V, Uusimaa J, Hakkola J. FASEB J. 2014 Jul;28(7):3225-37. doi: 10.1096/fj.13-245241. Epub 2014 Mar 31. PubMed |
| Metformin ameliorates insulin resistance in L6 rat skeletal muscle cells through upregulation of SIRT3. Song Y, Shi J, Wu Y, Han C, Zou J, Shi Y, Liu Z. Chin Med J (Engl). 2014;127(8):1523-9. PubMed |
| SIRT6 rescues the age related decline in base excision repair in a PARP1-dependent manner. Xu Z, Zhang L, Zhang W, Meng D, Zhang H, Jiang Y, Xu X, Van Meter M, Seluanov A, Gorbunova V, Mao Z. Cell Cycle. 2015;14(2):269-76. doi: 10.4161/15384101.2014.980641. PubMed |
| Inhibition of myocardial reperfusion injury by ischemic postconditioning requires sirtuin 3-mediated deacetylation of cyclophilin D. Bochaton T, Crola-Da-Silva C, Pillot B, Villedieu C, Ferreras L, Alam MR, Thibault H, Strina M, Gharib A, Ovize M, Baetz D. J Mol Cell Cardiol. 2015 Jul;84:61-9. doi: 10.1016/j.yjmcc.2015.03.017. Epub 2015 Apr 11. PubMed |
| SIRT3 inhibits prostate cancer by destabilizing oncoprotein c-MYC through regulation of the PI3K/Akt pathway. Quan Y, Wang N, Chen Q, Xu J, Cheng W, Di M, Xia W, Gao WQ. Oncotarget. 2015 Sep 22;6(28):26494-507. doi: 10.18632/oncotarget.4764. PubMed |
| Trimethylamine-N-Oxide Induces Vascular Inflammation by Activating the NLRP3 Inflammasome Through the SIRT3-SOD2-mtROS Signaling Pathway. Chen ML, Zhu XH, Ran L, Lang HD, Yi L, Mi MT. J Am Heart Assoc. 2017 Sep 4;6(9). pii: JAHA.117.006347. doi: 10.1161/JAHA.117.006347. PubMed |
| Regulation of SIRT3 signal related metabolic reprogramming in gastric cancer by Helicobacter pylori oncoprotein CagA. Lee DY, Jung DE, Yu SS, Lee YS, Choi BK, Lee YC. Oncotarget. 2017 Jun 27;8(45):78365-78378. doi: 10.18632/oncotarget.18695. eCollection 2017 Oct 3. PubMed |
| SIRT3 inhibits prostate cancer metastasis through regulation of FOXO3A by suppressing Wnt/beta-catenin pathway. Li R, Quan Y, Xia W. Exp Cell Res. 2018 Mar 15;364(2):143-151. doi: 10.1016/j.yexcr.2018.01.036. Epub 2018 Feb 6. PubMed |
| SIRT2 deacetylase regulates the activity of GSK3 isoforms independent of inhibitory phosphorylation. Sarikhani M, Mishra S, Maity S, Kotyada C, Wolfgeher D, Gupta MP, Singh M, Sundaresan NR. Elife. 2018 Mar 5;7. pii: 32952. doi: 10.7554/eLife.32952. PubMed |
| De novo expression of transfected sirtuin 3 enhances susceptibility of human MCF-7 breast cancer cells to hyperoxia treatment. Pinteric M, Podgorski II, Sobocanec S, Popovic Hadzija M, Paradzik M, Dekanic A, Marinovic M, Halasz M, Beluzic R, Davidovic G, Ambriovic Ristov A, Balog T. Free Radic Res. 2018 Jun;52(6):672-684. doi: 10.1080/10715762.2018.1462495. Epub 2018 Apr 23. PubMed |
| AMP kinase promotes glioblastoma bioenergetics and tumour growth. Chhipa RR, Fan Q, Anderson J, Muraleedharan R, Huang Y, Ciraolo G, Chen X, Waclaw R, Chow LM, Khuchua Z, Kofron M, Weirauch MT, Kendler A, McPherson C, Ratner N, Nakano I, Dasgupta N, Komurov K, Dasgupta B. Nat Cell Biol. 2018 Jul;20(7):823-835. doi: 10.1038/s41556-018-0126-z. Epub 2018 Jun 18. PubMed |
| Dexmedetomidine attenuation of renal ischaemia-reperfusion injury requires sirtuin 3 activation. Si Y, Bao H, Han L, Chen L, Zeng L, Jing L, Xing Y, Geng Y. Br J Anaesth. 2018 Dec;121(6):1260-1271. doi: 10.1016/j.bja.2018.07.007. Epub 2018 Sep 15. PubMed |
| Combination of sirtuin 3 and hyperoxia diminishes tumorigenic properties of MDA-MB-231 cells. Podgorski II, Pinteric M, Marcinko D, Popovic Hadzija M, Filic V, Ciganek I, Plese D, Balog T, Sobocanec S. Life Sci. 2020 Aug 1;254:117812. doi: 10.1016/j.lfs.2020.117812. Epub 2020 May 16. PubMed |
| Honokiol ameliorates angiotensin II-induced hypertension and endothelial dysfunction by inhibiting HDAC6-mediated cystathionine gamma-lyase degradation. Chi Z, Le TPH, Lee SK, Guo E, Kim D, Lee S, Seo SY, Lee SY, Kim JH, Lee SY. J Cell Mol Med. 2020 Sep;24(18):10663-10676. doi: 10.1111/jcmm.15686. Epub 2020 Aug 4. PubMed |
| Transcriptional Repression of SIRT3 Potentiates Mitochondrial Aconitase Activation to Drive Aggressive Prostate Cancer to the Bone. Sawant Dessai A, Dominguez MP, Chen UI, Hasper J, Prechtl C, Yu C, Katsuta E, Dai T, Zhu B, Jung SY, Putluri N, Takabe K, Zhang XH, O'Malley BW, Dasgupta S. Cancer Res. 2021 Jan 1;81(1):50-63. doi: 10.1158/0008-5472.CAN-20-1708. Epub 2020 Oct 28. PubMed |
| CD38 deficiency alleviates Ang II-induced vascular remodeling by inhibiting small extracellular vesicle-mediated vascular smooth muscle cell senescence in mice. Gan L, Liu D, Liu J, Chen E, Chen C, Liu L, Hu H, Guan X, Ma W, Zhang Y, He Y, Liu B, Tang S, Jiang W, Xue J, Xin H. Signal Transduct Target Ther. 2021 Jun 11;6(1):223. doi: 10.1038/s41392-021-00625-0. PubMed |
| APC/C CDH1 ubiquitinates IDH2 contributing to ROS increase in mitosis. Lambhate S, Bhattacharjee D, Jain N. Cell Signal. 2021 Oct;86:110087. doi: 10.1016/j.cellsig.2021.110087. Epub 2021 Jul 13. PubMed |
| Interplay between protein acetylation and ubiquitination controls MCL1 protein stability. Shimizu K, Gi M, Suzuki S, North BJ, Watahiki A, Fukumoto S, Asara JM, Tokunaga F, Wei W, Inuzuka H. Cell Rep. 2021 Nov 9;37(6):109988. doi: 10.1016/j.celrep.2021.109988. PubMed |
| Sirtuin-1 sensitive lysine-136 acetylation drives phase separation and pathological aggregation of TDP-43. Garcia Morato J, Hans F, von Zweydorf F, Feederle R, Elsasser SJ, Skodras AA, Gloeckner CJ, Buratti E, Neumann M, Kahle PJ. Nat Commun. 2022 Mar 9;13(1):1223. doi: 10.1038/s41467-022-28822-7. PubMed |
| Liver-specific overexpression of SIRT3 enhances oxidative metabolism, but does not impact metabolic defects induced by high fat feeding in mice. Osborne B, Reznick J, Wright LE, Sinclair DA, Cooney GJ, Turner N. Biochem Biophys Res Commun. 2022 Jun 4;607:131-137. doi: 10.1016/j.bbrc.2022.03.088. Epub 2022 Mar 18. PubMed |
| Tumor growth of neurofibromin-deficient cells is driven by decreased respiration and hampered by NAD(+) and SIRT3. Masgras I, Cannino G, Ciscato F, Sanchez-Martin C, Darvishi FB, Scantamburlo F, Pizzi M, Menga A, Fregona D, Castegna A, Rasola A. Cell Death Differ. 2022 Apr 7. pii: 10.1038/s41418-022-00991-4. doi: 10.1038/s41418-022-00991-4. PubMed |
| Sirtuin3 ensures the metabolic plasticity of neurotransmission during glucose deprivation. Tiwari A, Hashemiaghdam A, Laramie MA, Maschi D, Haddad T, Stunault MI, Bergom C, Javaheri A, Klyachko V, Ashrafi G. bioRxiv. 2023 Mar 10:2023.03.08.531724. doi: 10.1101/2023.03.08.531724. Preprint. PubMed |
Sirtuin3 ensures the metabolic plasticity of neurotransmission during glucose deprivation.
Tiwari A, Hashemiaghdam A, Laramie MA, Maschi D, Haddad T, Stunault MI, Bergom C, Javaheri A, Klyachko V, Ashrafi G.
J Cell Biol. 2024 Jan 1;223(1):e202305048. doi: 10.1083/jcb.202305048. Epub 2023 Nov 21.
PubMed
Associated Plasmids |
| Mitochondrial SIRT3 as a protective factor against cyclosporine A-induced nephrotoxicity. Kim JE, Jo MJ, Bae SY, Ahn SY, Ko GJ, Kwon YJ. Sci Rep. 2024 May 2;14(1):10143. doi: 10.1038/s41598-024-60453-4. PubMed |
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