myrAkt delta4-129 Citations (33)
Originally described in: Akt, a pleckstrin homology domain containing kinase, is activated primarily by phosphorylation.Kohn AD, Takeuchi F, Roth RA J Biol Chem. 1996 Sep 6. 271(36):21920-6. PubMed Journal
Articles Citing myrAkt delta4-129
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| Tissue inhibitor of metalloproteinase 3 suppresses tumor angiogenesis in matrix metalloproteinase 2-down-regulated lung cancer. Chetty C, Lakka SS, Bhoopathi P, Kunigal S, Geiss R, Rao JS. Cancer Res. 2008 Jun 15. 68(12):4736-45. PubMed |
| RNAi-mediated downregulation of radiation-induced MMP-9 leads to apoptosis via activation of ERK and Akt in IOMM-Lee cells. Gogineni VR, Kargiotis O, Klopfenstein JD, Gujrati M, Dinh DH, Rao JS. Int J Oncol. 2009 Jan;34(1):209-18. PubMed |
| MMP-2 alters VEGF expression via alphaVbeta3 integrin-mediated PI3K/AKT signaling in A549 lung cancer cells. Chetty C, Lakka SS, Bhoopathi P, Rao JS. Int J Cancer. 2010 Sep 1;127(5):1081-95. doi: 10.1002/ijc.25134. PubMed |
| A positive feedback loop between HER2 and ADAM12 in human head and neck cancer cells increases migration and invasion. Rao VH, Kandel A, Lynch D, Pena Z, Marwaha N, Deng C, Watson P, Hansen LA. Oncogene. 2012 Jun 7;31(23):2888-98. doi: 10.1038/onc.2011.460. Epub 2011 Oct 10. PubMed |
| SPARC overexpression inhibits cell proliferation in neuroblastoma and is partly mediated by tumor suppressor protein PTEN and AKT. Bhoopathi P, Gorantla B, Sailaja GS, Gondi CS, Gujrati M, Klopfenstein JD, Rao JS. PLoS One. 2012;7(5):e36093. doi: 10.1371/journal.pone.0036093. Epub 2012 May 2. PubMed |
| Overexpression of Akt1 enhances adipogenesis and leads to lipoma formation in zebrafish. Chu CY, Chen CF, Rajendran RS, Shen CN, Chen TH, Yen CC, Chuang CK, Lin DS, Hsiao CD. PLoS One. 2012;7(5):e36474. doi: 10.1371/journal.pone.0036474. Epub 2012 May 18. PubMed |
| A comprehensive small interfering RNA screen identifies signaling pathways required for gephyrin clustering. Wuchter J, Beuter S, Treindl F, Herrmann T, Zeck G, Templin MF, Volkmer H. J Neurosci. 2012 Oct 17;32(42):14821-34. doi: 10.1523/JNEUROSCI.1261-12.2012. PubMed |
| Heterogeneous kinetics of AKT signaling in individual cells are accounted for by variable protein concentration. Meyer R, D'Alessandro LA, Kar S, Kramer B, She B, Kaschek D, Hahn B, Wrangborg D, Karlsson J, Kvarnstrom M, Jirstrand M, Lehmann WD, Timmer J, Hofer T, Klingmuller U. Front Physiol. 2012 Nov 28;3:451. doi: 10.3389/fphys.2012.00451. eCollection 2012. PubMed |
| The soluble Decoy Receptor 3 is regulated by a PI3K-dependent mechanism and promotes migration and invasion in renal cell carcinoma. Weissinger D, Tagscherer KE, Macher-Goppinger S, Haferkamp A, Wagener N, Roth W. Mol Cancer. 2013 Oct 10;12(1):120. doi: 10.1186/1476-4598-12-120. PubMed |
| A homeostatic function of CXCR2 signalling in articular cartilage. Sherwood J, Bertrand J, Nalesso G, Poulet B, Pitsillides A, Brandolini L, Karystinou A, De Bari C, Luyten FP, Pitzalis C, Pap T, Dell'Accio F. Ann Rheum Dis. 2014 Aug 18. pii: annrheumdis-2014-205546. doi: 10.1136/annrheumdis-2014-205546. PubMed |
| Synergism of PI3K/Akt inhibition and Fas activation on colon cancer cell death. Zhu L, Derijard B, Chakrabandhu K, Wang BS, Chen HZ, Hueber AO. Cancer Lett. 2014 Nov 28;354(2):355-64. doi: 10.1016/j.canlet.2014.08.038. Epub 2014 Sep 6. PubMed |
| FOXC2 promotes colorectal cancer metastasis by directly targeting MET. Cui YM, Jiao HL, Ye YP, Chen CM, Wang JX, Tang N, Li TT, Lin J, Qi L, Wu P, Wang SY, He MR, Liang L, Bian XW, Liao WT, Ding YQ. Oncogene. 2015 Aug 13;34(33):4379-90. doi: 10.1038/onc.2014.368. Epub 2014 Nov 10. PubMed |
| Akt mediated phosphorylation of LARP6; critical step in biosynthesis of type I collagen. Zhang Y, Stefanovic B. Sci Rep. 2016 Mar 2;6:22597. doi: 10.1038/srep22597. PubMed |
| Englerin A Inhibits EWS-FLI1 DNA Binding in Ewing Sarcoma Cells. Caropreso V, Darvishi E, Turbyville TJ, Ratnayake R, Grohar PJ, McMahon JB, Woldemichael GM. J Biol Chem. 2016 May 6;291(19):10058-66. doi: 10.1074/jbc.M115.701375. Epub 2016 Mar 9. PubMed |
| GSK3beta regulates AKT-induced central nervous system axon regeneration via an eIF2Bepsilon-dependent, mTORC1-independent pathway. Guo X, Snider WD, Chen B. Elife. 2016 Mar 14;5:e11903. doi: 10.7554/eLife.11903. PubMed |
| CADM1 inhibits squamous cell carcinoma progression by reducing STAT3 activity. Vallath S, Sage EK, Kolluri KK, Lourenco SN, Teixeira VS, Chimalapati S, George PJ, Janes SM, Giangreco A. Sci Rep. 2016 Apr 1;6:24006. doi: 10.1038/srep24006. PubMed |
Primate TRIM5 proteins form hexagonal nets on HIV-1 capsids.
Li YL, Chandrasekaran V, Carter SD, Woodward CL, Christensen DE, Dryden KA, Pornillos O, Yeager M, Ganser-Pornillos BK, Jensen GJ, Sundquist WI.
Elife. 2016 Jun 2;5. pii: e16269. doi: 10.7554/eLife.16269.
PubMed
Associated Plasmids |
| Increased ROS production in non-polarized mammary epithelial cells induces monocyte infiltration in 3D culture. Li L, Chen J, Xiong G, St Clair DK, Xu W, Xu R. J Cell Sci. 2017 Jan 1;130(1):190-202. doi: 10.1242/jcs.186031. Epub 2016 Sep 21. PubMed |
| Targeting insulin-like growth factor-binding protein-3 by microRNA-125b promotes tumor invasion and poor outcomes in non-small-cell lung cancer. Wang HH, Wang YC, Wu DW, Hung CS, Chen CY, Lee H. Tumour Biol. 2017 Apr;39(4):1010428317694316. doi: 10.1177/1010428317694316. PubMed |
Generation of an OCT4 reporter human induced pluripotent stem cell line using CRISPR/SpCas9.
Balboa D, Weltner J, Novik Y, Eurola S, Wartiovaara K, Otonkoski T.
Stem Cell Res. 2017 Aug;23:105-108. doi: 10.1016/j.scr.2017.07.006. Epub 2017 Jul 11.
PubMed
Associated Plasmids |
| The geranyl acetophenone tHGA attenuates human bronchial smooth muscle proliferation via inhibition of AKT phosphorylation. Yap HM, Lee YZ, Harith HH, Tham CL, Cheema MS, Shaari K, Israf DA. Sci Rep. 2018 Nov 9;8(1):16640. doi: 10.1038/s41598-018-34847-0. PubMed |
| Alborixin clears amyloid-beta by inducing autophagy through PTEN-mediated inhibition of the AKT pathway. Wani A, Gupta M, Ahmad M, Shah AM, Ahsan AU, Qazi PH, Malik F, Singh G, Sharma PR, Kaddoumi A, Bharate SB, Vishwakarma RA, Kumar A. Autophagy. 2019 Oct;15(10):1810-1828. doi: 10.1080/15548627.2019.1596476. Epub 2019 Apr 2. PubMed |
| Dual PI3K/mTOR Inhibitor, XL765, suppresses glioblastoma growth by inducing ER stress-dependent apoptosis. Zhao H, Chen G, Liang H. Onco Targets Ther. 2019 Jul 8;12:5415-5424. doi: 10.2147/OTT.S210128. eCollection 2019. PubMed |
| The RNA helicase DDX3 induces neural crest by promoting AKT activity. Perfetto M, Xu X, Lu C, Shi Y, Yousaf N, Li J, Yien YY, Wei S. Development. 2021 Jan 19;148(2). pii: dev.184341. doi: 10.1242/dev.184341. PubMed |
| Preventing tumor progression to the bone by induced tumor-suppressing MSCs. Sun X, Li K, Zha R, Liu S, Fan Y, Wu D, Hase M, Aryal UK, Lin CC, Li BY, Yokota H. Theranostics. 2021 Mar 5;11(11):5143-5159. doi: 10.7150/thno.58779. eCollection 2021. PubMed |
| TRAF6 Promoted Tumor Glycolysis in Non-Small-Cell Lung Cancer by Activating the Akt-HIFalpha Pathway. Feng L, Feng S, Nie Z, Deng Y, Xuan Y, Chen X, Lu Y, Liang L, Chen Y. Biomed Res Int. 2021 Aug 6;2021:3431245. doi: 10.1155/2021/3431245. eCollection 2021. PubMed |
| The Akt Forkhead Box O Transcription Factor Axis Regulates Human Cytomegalovirus Replication. Zhang H, Domma AJ, Goodrum FD, Moorman NJ, Kamil JP. mBio. 2022 Aug 30;13(4):e0104222. doi: 10.1128/mbio.01042-22. Epub 2022 Aug 10. PubMed |
| PI3K-activated MSC proteomes inhibit mammary tumors via Hsp90ab1 and Myh9. Sun X, Li K, Aryal UK, Li BY, Yokota H. Mol Ther Oncolytics. 2022 Aug 5;26:360-371. doi: 10.1016/j.omto.2022.08.003. eCollection 2022 Sep 15. PubMed |
| Identification and evaluation of midbrain specific longevity-related genes in exceptionally long-lived but healthy mice. Kim H, Huh YJ, Kim JH, Jo M, Shin JH, Park SC, Ahn JY, Lee YI, Lee Y. Front Aging Neurosci. 2023 Jan 11;14:1030807. doi: 10.3389/fnagi.2022.1030807. eCollection 2022. PubMed |
| Hypo-osmolarity induces apoptosis resistance via TRPV2-mediated AKT-Bcl-2 pathway. Urushima H, Matsubara T, Miyakoshi M, Kimura S, Yuasa H, Yoshizato K, Ikeda K. Am J Physiol Gastrointest Liver Physiol. 2023 Mar 1;324(3):G219-G230. doi: 10.1152/ajpgi.00138.2022. Epub 2023 Jan 31. PubMed |
| RIDR-PI-103, ROS-activated prodrug PI3K inhibitor inhibits cell growth and impairs the PI3K/Akt pathway in BRAF and MEK inhibitor-resistant BRAF-mutant melanoma cells. Patel H, Mishra R, Wier A, Mokhtarpour N, Merino EJ, Garrett JT. Anticancer Drugs. 2023 Apr 1;34(4):519-531. doi: 10.1097/CAD.0000000000001500. Epub 2023 Feb 10. PubMed |
| Proteomes from AMPK-inhibited peripheral blood mononuclear cells suppress the progression of breast cancer and bone metastasis. Li K, Sun X, Minami K, Tamari K, Ogawa K, Li H, Ma H, Zhou M, Na S, Li BY, Yokota H. Theranostics. 2023 Feb 5;13(4):1247-1263. doi: 10.7150/thno.80294. eCollection 2023. PubMed |
| Virion-associated US28 rapidly modulates Akt activity to suppress HCMV lytic replication in monocytes. Mahmud J, Geiler BW, Biswas J, Miller MJ, Myers JE, Matthews SM, Wass AB, O'Connor CM, Chan GC. bioRxiv [Preprint]. 2023 Sep 5:2023.09.05.556359. doi: 10.1101/2023.09.05.556359. PubMed |
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