Chemogenetics Guide
Type
Guide
...For example, PSAM Q79G,Q139G is activated by PSEM 22S , while PSAM L141F,Y115F is activated by PSEM 89S...influx of Na+ and/or K+ ions, and activates neuronal activity. Figure 2. PSAM4-based LGICs, their effect, and...endogenous ligands, have low constitutive activity, and their activating ligands have few, if any off-target...First Structure–Activity Relationship Studies for Designer Receptors Exclusively Activated by Designer Drugs...off-target activity, and do not seem to have the same back-metabolism issues as CNO and are attractive alternatives...harmacologically S elective A ctuator M odules (PSAMs, pronounced SAMs). PSAMs are engineered α7 nicotinic acetylcholine...Cl- ions, and inhibits neuronal activity. PSAM-5HT3 LGICs pair a PSAM domain with a 5-HT 3 serotonin receptor...