... N ‐oxide (CNO). CNO is a metabolite of the antipsychotic clozapine and seems to be pharmacologically ...however, it has off-target effects. The atypical antipsychotic drug olanzapine has also been shown to be an...common property of either typical or atypical antipsychotic drugs: is M1 agonism a pre-requisite for mimicking...mimicking clozapine’s actions? Psychopharmacology. 178:451–460. PMID: 15765260 (Link opens in a new window...cAMP Production in Striatopallidal Neurons. Neuropsychopharmacol. 38:854–862. PMID: 23303063 (Link opens ...