Chemogenetics Guide
Type
Guide
...coupled receptors? Read the GPCRs: How Do They Work and How Do We Study Them? blog! Studies of GPCRs led...are engineered to respond to small molecules that do not affect endogenous signalling, therefore allowing...DCZ seem to have minimal off-target activity, and do not seem to have the same back-metabolism issues ... consider: Chemogenetic activation or inhibition. Do you want to turn ON or turn OFF neurons in your experiment...high potency, which is potentially important for dosing in animal studies, made them attractive targets...