... to learn more! Background: Argonaute and NgAgo In eukaryotes, Argonaute proteins play an important role...searched for Argonaute orthologs similar to TtAgo and PfAgo, another thermophilic Argonaute. They identified... newest gene-editing protein - a DNA-cleaving Argonaute from Natronobacterium gregoryi, or NgAgo for short...interference, binding RNA guides to cleave foreign RNA. Argonaute proteins are also present in prokaryotes, and ...invading DNA. In 2014, Swarts et al. characterized Argonaute from Thermus thermophilus (TtAgo), showing that...genome editing using the Natronobacterium gregoryi Argonaute.” Nat Biotechnol. Epub 2016 May 2. PubMed PMID...“DNA-guided DNA interference by a prokaryotic Argonaute.” Nature. 507(7491) (2014):258-61. PubMed PMID...

...siRNA) and they bind to a class of Argonaute proteins. The Argonaute proteins remove one strand of the ...mRNAs.These native mRNAs are subsequently destroyed by Argonaute-catalyzed nuclease activity or their translation...

...pipetting and happy genome editing! Check Out Other Argonaute Plasmids from the Doudna Lab Many thanks to our...genome editing using the Natronobacterium gregoryi Argonaute." Nature biotechnology (2016). PubMed PMID: 27136078...

...ReFigure about whether Natronobacterium gregoryi Argonaute has any DNA editing functionality Collecting preclinical...

...one step further, his lab is now studying how Argonaute pathways may be involved in preventing silencing...