Viral Vectors 101: An Introduction to AAV
Type
Blog Post
Published
May 30, 2023, 1:15 p.m.
...promoters from subretinal injections of neonatal mouse eyes at two different ages." Retinal Degenerative...optogenetics, and chemogenetics experiments.
Recombinant AAVs (rAAVs)
The primary application of AAV is...meaning that all viral genes except ITRs (inverted terminal repeats – the sequences that flank the deliverable...deliverable DNA) are removed, resulting in recombinant AAVs (rAAVs) with maximum “trunk” space for genetic ...placed in your cell type of interest. Careful combination of promoters, gene switches, and/or serotype ...dividing tissues will lose expression quicker than terminally differentiated, non-dividing cells.
...size of the ssAAV genome has a mutation in the terminal resolution site (TRS) to form a vector genome ...