...includes four promoters, six fluorophores with nonoverlapping emission spectra (N- and C-terminal tags for...using these tools in virtually any vertebrate. This novel AAV approach allows you to target and functionally...Podcast Segment on This New AAV Tool    mCyRFP1: Novel fluorescent protein that enables imaging of two ...Lin and Ryohei Yasuda have teamed up to develop a novel monomeric cyan-excitable red fluorescent protein...

...one, is a sterling example of collaboration and innovation between legal and scientific fields.” Thanks ... every day for their dedication, flexibility, innovative thinking, and openness to team work.   Company...positions. We have an awesome talent pipeline. Turnover at Addgene is about half of what is standard in...

...Research Strategy highlights i) the significance and innovation of the project and ii) how you, the expert, will...writing a proposal to test hypotheses and develop novel technologies! If data from a publication or preliminary...funding. Convince the readers why and how your innovation will address a variety of challenges and impact...

... in the lab are gamma retrovirus, lentivirus, adenovirus, and adeno-associated virus (AAV). The least ...is usually classified as a BSL-1 safety level. Adenovirus is similar to AAV in that it does not integrate...integrate into the host’s genome. However, some adenovirus strains are known to cause respiratory diseases ...

...replicate itself and depends on helper viruses like adenovirus (Ad) or herpes simplex virus to facilitate efficient...a “helper-free” system, in which the required adenoviral helper genes are supplied on two different packaging..., J. (1999). Titration of AAV-2 particles via a novel capsid ELISA: Packaging of genomes can limit production...

...expressing your gene, especially if you are studying a novel gene, is not always a straightforward process. Rather... of interest, scientists have instead developed novel methods to co-express your gene along with a reporter...more time developing the clever experiments and innovative solutions necessary for advancing the field. ...

...locomotor sensitization and might open new ways for a novel therapeutic approach against drug addiction. Anxiety...illuminated ones (risky). They also prefer to explore novel environments by initially moving along a wall (protected...bright place, driven by their motivation to explore novel environments, rather than being inhibited by fear...

...members are linked to viral susceptibility (mouse adenovirus in mouse; HIV1, West Nile, and Influenza in humans...finding illustrates how the method used to select novel AAV capsid variants could unintentionally limit ...Delivering genes across the blood-brain barrier: LY6A, a novel cellular receptor for AAV-PHP. B capsids." bioRxiv...

... publish on the health and economic benefits of novel drugs. Commercial Affairs teams make up a large ...for cancer with chemotherapies, or developing innovative mobile phone applications and services that help...the more challenging parts of the job? With fast turnover of projects, pressure to maintain consistently...

...co-founded by Kaspar, acquired by Novartis and rebranded to Novartis Gene Therapies, and Taysha Gene Therapies... in tackling the root cause of Rett Syndrome in novel ways.  Addgene’s MECP2 Plasmid Collection and Resource...

...developed NIR split probes (Tchekanda et al., 2014, Filonov et al., 2013). FRET biosensors were developed based... interactions. Nat Methods 11, 641-644 (2014). Filonov, G.S. & Verkhusha, V.V. A near-infrared BiFC reporter... vivo imaging. Nat Methods 10, 751-754 (2013). Filonov, G.S. et al. Bright and stable near-infrared fluorescent...

...inhibited. Recently, we at the Institute for Protein Innovation (IPI), a Boston-based, nonprofit protein research...recombinant antibodies (rAbs) either produced de novo using yeast display technology or produced from ...a science writer at the Institute for Protein Innovation. She writes about all things IPI, from the scientists...

...for inhibition of AcrB multidrug efflux pump by novel and powerful pyranopyridine derivatives." Proceedings...Academy of Sciences 113.13 (2016): 3509-3514. Tikhonova, Elena B., et al. "A transcription blocker isolated...metalloproteinase: López-Pelegrín, Mar, et al. "A novel mechanism of latency in matrix metalloproteinases...

....2022.07.010 Issa, S. S., Shaimardanova, A. A., Solovyeva, V. V., & Rizvanov, A. A. (2023). Various AAV... Comparison of Gene Delivery to the Kidney by Adenovirus, Adeno-Associated Virus, and Lentiviral Vectors...

...vesicular stomatitis virus (VSV; Beier et al., 2011), adenovirus, and adeno-associated virus (AAV), have been ...the California Institute of Technology generated novel AAVs (Chan et al., 2017) that express one of a few...type-specific genetic and optogenetic tools reveal novel hippocampal CA2 circuits. Nat Neurosci 17(2), 269...

...Mark your calendars for November 16-20, 2020 for #DepositorWeek on Twitter!  That’s today through Friday...presented in this blog post includes data until November 9, 2020. Between then and the posting of the blog...

...vector. Moreover, the screen identified putative novel regulators of CD8+ T cell responses in tumors, demonstrating... demonstrating that this system can also reveal novel pathways. The FITS deposit also includes pLX_305...

...University of Edinburgh where he worked on developing novel systems for bioconversion of cellulosic biomass ...spend some time learning and doing research at Novartis. Listen to learn how Kwabena plans to use his ...

...Colorado, Berlin, Atlanta, Ottawa, Norwich, and Hannover, we raised money for the Superhero 5k and, of ...Increased Postdoc Wages I hope you all have a great November! Tyler J. Ford ...

...Chapter 2: The Centre for Synthetic Biology and Innovation - A shared space for bringing synthetic biology...researcher at the Centre for Synthetic Biology and Innovation, Imperial College London and lectures synthetic...