...vectors to study the neural circuitry behind the mechanisms of sleep and anesthesia. In Cre transgenic mice...optogenetics to understand the cellular and molecular mechanisms of the brain in vivo. Many thanks to our guest...rhodopsins: structures, functions, and molecular mechanisms." Chemical reviews 114.1 (2013): 126-163. PubMed...

... a wide range of organisms and cell lines. In C. elegans, one of the model organisms which I use to study...methods – could greatly streamline editing in other organisms and systems, allowing rapid progress in a wide...

...organs, and most importantly escape the immune mechanisms of the host. The cause, manifestation, diagnosis...this phase are able to outsmart the host immune mechanisms altogether and escape future immune surveillance...of colorectal cancer. Strategic immune evasion mechanisms - The tumor microenvironment Through interactions...

...plasmids due to lower activation of DNA-silencing mechanisms. While minicircles are typically smaller than...) studies focused on better understanding the mechanisms of reprogramming, and 2) studies with clinical...Hochedlinger. "Induced pluripotency: history, mechanisms, and applications." Genes & Development 24, no...

...listed? Help us serve you! Let us know about other organisms we should include by emailing us at [email protected] narrow your keyword search to one of these organisms. Help us continue to develop resources for your...

...scientists to edit the genome of virtually any organisms on this planet, CRISPR-Cas systems were merely... to quickly detect the presence of infectious organisms (ex: SARS-CoV-2) and genetic mutations. By providing...

...inner structures of delicate plants and other organisms without destroying the original, which could provide...Do you look for the beauty in the microscopic organisms on your lab bench? Let us know in the comments...

... editing tool of choice for a number of model organisms: mammalian cells, yeast, drosophila, plants, worms...obligate thermophiles without the need to grow the organisms at lower than optimal temperatures. GeoCas9’s ...

...versatile and can be applied across cell types and organisms by replacing the transcription factor binding ...the PhiC31 recombinase can work in other model organisms including mouse and fish, SPARC is likely generalizable...

...cleavage. Secondly, fluorescence imaging of living organisms can be challenging due to issues with tissue autofluorescence...dynamics of apoptosis both in vitro and in living organisms to better study and understand these diseases ...

... can function to break membranes of different organisms. And finally, we demonstrated that R bodies can...speculatively, R bodies might endow divergent organisms with new functions. For inspiration, we can look...

...investigate the susceptibility of cells from different organisms to SARS-CoV-2 (Chu et al., 2020). An additional...for the advancement of scientific research, and mechanisms to maintain and grow these critical organizations...

...Viral delivery has several advantages over other mechanisms. For one, many viral platforms, such as AAV or...analyte. This can be difficult to achieve in whole organisms, but AAVs make it possible. In AAV systems, different...

...basics.  Mesophiles vs. extremophiles Mesophilic organisms are your regular next-door microbes which grow...cold conditions. However, many of the detailed mechanisms that allow extremophiles to survive under these...

...mutagenizing a population (typically cells or small organisms) and then assaying for a functional or phenotypical... events. To put it another way, only cells or organisms with the desired phenotype will survive and be...

... Fig. 1 CRISPR activator and repressor mechanisms Want to transiently induce expression? Check...post-translational level, unlike most of the other mechanisms described. Fig. 3 dTag mechanism of protein...

...many guides/parts delivered) in certain model organisms. In mammals, most CRISPR libraries are assembled...targeting constructs and delivering them to these organisms via another optimized platform. Gene Stacking ...

...Prokaryotic termination   Prokaryotic termination mechanisms fall under two general categories: rho-dependent...dependent, Polymerases I and II employ different mechanisms to terminate transcription. Polymerase I uses...

...fluorescent when ectopically expressed in most organisms. Furthermore, fusing FPs to another protein usually...Additionally, many other FPs have been found in other organisms. Blue 424 - 467 nm Cyan 474 - 492 nm Green...

...sea anemone (Chan et al., 2006). Why do these organisms have chromoproteins? One reason may be that chromoproteins...symbiotic algae, during heat stress. For other organisms, like the sea anemone, scientists think that chromoproteins...