Minigenomes - a Safe Way to Study Dangerous Viruses Like the Ebola Virus
Type
Blog Post
Published
March 17, 2016, 2:30 p.m.
...these components are necessary to efficiently reconstitute a functional viral polymerase complex and utilize...proteins are provided in trans (see Other Important Components of EBOV Minigenome System). However, minigenomes...RNA viruses (reviewed in 2, 3).
Other important components of the Zaire ebola virus minigenome system
Similar...with the viral polymerase, which is formed by a complex of two proteins: the large (L) catalytic protein...-stranded RNA minigenome. The viral polymerase complex then recognizes the encapsidated minigenome as ... genes in this plasmid would be more difficult compared to if each gene were encoded in separate (and ...particular observation can be easily studied as each component can be examined independently. In addition, experiments...