Starter Guide to induced Pluripotent Stem Cells (iPSCs) Part 2: Reprogramming and Transdifferentiation
Type
Blog Post
Published
Nov. 6, 2018, 1:12 p.m.
...dedifferentiation stage involves overexpression of four reprogramming factors- OCT4, SOX2, KLF4, and C-MYC - that...More (due to additional pluripotency stage)
Less
Safety
Less (C-MYC, a known oncogene is one of the reprogramming...lineage, without dedifferentiating into a pluripotent stage.
Cellular reprogramming
The reversal of a differentiated...reprogramming [1]. The process can be divided into two stages:
Dedifferentiation - Conversion of adult somatic...differentiated somatic cell to revert back to a pluripotent stage (iPSC formation) [2, 3]. The iPSCs then proliferate...reprogrammed to iPSCs successfully [10-12].
The next stage of reprogramming consists of redifferentiation of...