Expanding the Targeting Scope and Editing Efficiency of Adenine Base Editors
Type
Blog Post
Published
March 17, 2020, 1:32 p.m.
...following components:
A plasmid in the host bacterium expressing dCas9
A plasmid in the host bacterium ... of gene III to create infectious particles. A plasmid-based genetic circuit in the bacteria links the...encoding the deaminase TadA-7.10
A mutagenesis plasmid controlling the phage mutation rate
Phage infection...Phage-assisted evolution of base-editing activity. A plasmid-based genetic circuit in the bacteria links the...off-target RNA editing rate of ABE7.10.
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