Nuclear Receptor Plasmid Collection
Image is released to public domain by author. Source: Wikipedia, accessed November 6, 2013. Author: Boghog2
Nuclear receptors are a class of transcription factors modulated by ligands. Two of the important regions of nuclear receptors are: 1) a ligand binding domain, which interacts with hormones or other molecules, and 2) a DNA binding domain, which targets the receptor to specific DNA sequences. Ligand binding triggers a conformational change in the receptor and results in activation or repression of target gene expression. Nuclear receptors play a key role in development and homeostasis, and the receptors and their downstream genes are associated with numerous disease pathways.
In collaboration with research labs from around the globe, Addgene has assembled a Nuclear Receptor plasmid collection for the community. If you have created plasmids that you would like to add to this collection, email [email protected] to be paired with an Addgene scientist.
Nuclear Receptor Plasmids
| Find Plasmids by Gene Name | Alternative Gene Names | Gene Description |
|---|---|---|
| AR plasmids | AR, RP11-383C12.1, AIS, DHTR, HUMARA,HYSP1, KD, NR3C4, SBMA, SMAX1, TFM | androgen receptor |
| ESR2 Plasmids | ESR2, ER-BETA, ESR-BETA,ESRB, ESTRB, Erb, NR3A2 | estrogen receptor 2 (ER beta) |
| ESRRA Plasmids | ESRRA, ERR1, ERRa, ERRalpha, ESRL1, NR3B1 | estrogen-related receptor alpha |
| ESRRB Plasmids | ESRRB, DFNB35, ERR2, ERRb, ESRL2, NR3B2 | estrogen-related receptor beta |
| ESRRG Plasmids | ESRRG, ERR3, ERRgamma, NR3B3 | estrogen-related receptor gamma |
| HNF4A Plasmids | HNF4A, RP5-1013A22.1, HNF4, HNF4a7, HNF4a8, HNF4a9, HNF4alpha, MODY, MODY1, NR2A1, NR2A21, TCF, TCF14 | hepatocyte nuclear factor 4, alpha |
| NR0B1 Plasmids | NR0B1, AHC, AHCH, AHX, DAX-1, DAX1, DSS, GTD, HHG, NROB1, SRXY2 | nuclear receptor subfamily 0, group B, member 1 |
| NR1D1 Plasmids | NR1D1, EAR1, hRev, THRA1, THRAL, ear-1 | nuclear receptor subfamily 1, group D, member 1 |
| NR1D2 Plasmids | NR1D2, RVR, BD73, EAR-1R | nuclear receptor subfamily 1, group D, member 2 |
| NR1H3 Plasmids | NR1H3, LXR-a, LXRA, RLD-1 | nuclear receptor subfamily 1, group H, member 3 |
| NR2E1 Plasmids | NR2E1, RP3-429G5.1, TLL, TLX, XTLL | nuclear receptor subfamily 2, group E, member 1 |
| NR2F1 plasmids | NR2F1, COUP-TFI, EAR-3, EAR3, ERBAL3, NR2F2, SVP44, TCFCOUP1, TFCOUP1 | nuclear receptor subfamily 2, group F, member 1 |
| NR3C1 Plasmids | NR3C1, GCCR, GCR, GR, GRL | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) |
| NR3C2 Plasmids | NR3C2, MCR, MLR, MR, NR3C2VIT | nuclear receptor subfamily 3, group C, member 2 |
| NR4A1 Plasmids | NR4A1, GFRP1, HMR, N10, NAK-1, NGFIB, NP10, NUR77, TR3 | nuclear receptor subfamily 4, group A, member 1 |
| NR4A2 Plasmids | NR4A2, HZF-3, NOT, NURR1, RNR1, TINUR | nuclear receptor subfamily 4, group A, member 2 |
| NR5A1 Plasmids | NR5A1, RP11-101K10.1, AD4BP, ELP, FTZ1, FTZF1, POF7, SF-1, SF1, SPGF8, SRXY3 | nuclear receptor subfamily 5, group A, member 1 |
| NR5A2 Plasmids | NR5A2, B1F, B1F2, CPF, FTF, FTZ-F1, FTZ-F1beta, LRH-1, LRH1, hB1F-2 | nuclear receptor subfamily 5, group A, member 2 |
| NR6A1 Plasmids | NR6A1, GCNF, GCNF1, NR61, RTR, hGCNF, hRTR | nuclear receptor subfamily 6, group A, member 1 |
| PGR Plasmids | PGR, NR3C3, PR | progesterone receptor |
| PPARA Plasmids | PPARA, SC22CB-5E3.5, NR1C1, PPAR, PPARalpha, hPPAR | peroxisome proliferator-activated receptor alpha |
| PPARD Plasmids | PPARD, FAAR, NR1C2, NUC1, NUCI, NUCII, PPARB | peroxisome proliferator-activated receptor delta |
| PPARG Plasmids | PPARG, CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma | peroxisome proliferator-activated receptor gamma |
| RARA Plasmids | RARA, NR1B1, RAR | retinoic acid receptor, alpha |
| RORA Plasmids | RORA, ROR1, ROR2, ROR3, RZRA, NR1F1, MGC119326, MGC119329, RZR-ALPHA, DKFZp686M2414 | RAR-related orphan receptor A |
| RORB Plasmids | RORB, NR1F2, ROR-BETA, RZR-BETA, RZRB, bA133M9.1 | RAR-related orphan receptor B |
| RORC Plasmids | RORC, RP11-98D18.11-001, NR1F3, RORG, RZR-GAMMA, RZRG, TOR | RAR-related orphan receptor C |
| RXRA Plasmids | RXRA, NR2B1 | retinoid X receptor, alpha |
| RXRG Plasmids | RXRG, NR2B3, RXRC | retinoid X receptor, gamma |