Lithocholic acid binds TULP3 to activate sirtuins and AMPK to slow down ageing.
Qu Q, Chen Y, Wang Y, Wang W, Long S, Yang HY, Wu J, Li M, Tian X, Wei X, Liu YH, Xu S, Xiong J, Yang C, Wu Z, Huang X, Xie C, Wu Y, Xu Z, Zhang C, Zhang B, Feng JW, Chen J, Feng Y, Fang H, Lin L, Xie ZK, Sun B, Tian H, Yu Y, Piao HL, Xie XS, Deng X, Zhang CS, Lin SC
Nature. 2024 Dec 18. doi: 10.1038/s41586-024-08348-2.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 246129 | pcDNA 3.3 N-MYC ATP6V1A | Used for transfection of cells for expression N-MYC ATP6V1A |
| 246130 | pcDNA 3.3 N-MYC ATP6V1B2 | Used for transfection of cells for expression N-MYC ATP6V1B2 |
| 246131 | pcDNA 3.3 N-MYC ATP6V1C1 | Used for transfection of cells for expression N-MYC ATP6V1C1 |
| 246133 | pcDNA 3.3 N-MYC ATP6V1D | Used for transfection of cells for expression N-MYC ATP6V1D |
| 246134 | pcDNA 3.3 N-MYC ATP6V1E1 | Used for transfection of cells for expression N-MYC ATP6V1E1 |
| 246135 | pcDNA 3.3 N-MYC ATP6V1E2 | Used for transfection of cells for expression N-MYC ATP6V1E2 |
| 246136 | pcDNA 3.3 N-MYC ATP6V1F | Used for transfection of cells for expression N-MYC ATP6V1F |
| 246137 | pcDNA 3.3 N-MYC ATP6V1G1 | Used for transfection of cells for expression N-MYC ATP6V1G1 |
| 246138 | pcDNA 3.3 N-MYC ATP6V1G2 | Used for transfection of cells for expression N-MYC ATP6V1G2 |
| 246139 | pcDNA 3.3 N-MYC ATP6V1G3 | Used for transfection of cells for expression N-MYC ATP6V1G3 |
| 246140 | pcDNA 3.3 N-MYC ATP6V1H | Used for transfection of cells for expression N-MYC ATP6V1H |
| 246143 | pcDNA 3.3 N-MYC ATP6V0B | Used for transfection of cells for expression N-MYC ATP6V0B |
| 246144 | pcDNA 3.3 N-MYC ATP6V0C | Used for transfection of cells for expression N-MYC ATP6V0C |
| 246145 | pcDNA 3.3 N-MYC ATP6V0D1 | Used for transfection of cells for expression N-MYC ATP6V0D1 |
| 246146 | pcDNA 3.3 N-MYC ATP6V0D2 | Used for transfection of cells for expression N-MYC ATP6V0D2 |
| 246147 | pcDNA 3.3 N-MYC ATP6V0E1 | Used for transfection of cells for expression N-MYC ATP6V0E1 |
| 246148 | pcDNA 3.3 N-MYC ATP6AP1 | Used for transfection of cells for expression N-MYC ATP6AP1 |
| 246149 | pcDNA 3.3 N-MYC ATP6AP2 | Used for transfection of cells for expression N-MYC ATP6AP2 |
| 246150 | pBOBI N-HA HDAC1 | Used for transfection of cells for expression N-HA HDAC1 |
| 246156 | pBOBI N-HA HDAC7 | Used for transfection of cells for expression N-HA HDAC7 |
| 246157 | pBOBI N-HA HDAC8 | Used for transfection of cells for expression N-HA HDAC8 |
| 246159 | pBOBI N-HA HDAC10 | Used for transfection of cells for expression N-HA HDAC10 |
| 246160 | pBOBI N-HA HDAC11 | Used for transfection of cells for expression N-HA HDAC11 |
| 246161 | pcDNA 3.3 N-HA SIRT1 | Used for transfection of cells for expression N-HA SIRT1 |
| 246162 | pcDNA 3.3 N-HA SIRT2 | Used for transfection of cells for expression N-HA SIRT2 |
| 246163 | pcDNA 3.3 N-HA SIRT3 | Used for transfection of cells for expression N-HA SIRT3 |
| 246164 | pcDNA 3.3 N-HA SIRT4 | Used for transfection of cells for expression N-HA SIRT4 |
| 246166 | pcDNA 3.3 N-HA SIRT6 iso2 | Used for transfection of cells for expression N-HA SIRT6 iso2 |
| 246167 | pcDNA 3.3 N-HA SIRT7 | Used for transfection of cells for expression N-HA SIRT7 |
| 246170 | pcDNA 3.3 N-HA ATP6V1E1-11 | Used for transfection of cells for expression N-HA ATP6V1E1-11 |
| 246171 | pcDNA 3.3 N-HA ATP6V1E1-3KQ | Used for transfection of cells for expression N-HA ATP6V1E1-3KQ |
| 246172 | pcDNA 3.3 N-MYC TULP3 | Used for transfection of cells for expression N-MYC TULP3 |
| 246173 | pcDNA 3.3 N-HA TUB1 | Used for transfection of cells for expression N-HA TUB1 |
| 246175 | pcDNA 3.3 N-MYC TULP3-4G | Used for transfection of cells for expression N-MYC TULP3-4G |
| 246178 | pcDNA 3.3 N-MYC TULP3 1-183 | Used for transfection of cells for expression N-MYC TULP3 1-183 |
| 246179 | pcDNA 3.3 N-MYC TULP3 1-160 | Used for transfection of cells for expression N-MYC TULP3 1-160 |
| 246180 | pcDNA 3.3 N-MYC TULP3 1-140 | Used for transfection of cells for expression N-MYC TULP3 1-140 |
| 246181 | pcDNA 3.3 N-MYC TULP3 1-120 | Used for transfection of cells for expression N-MYC TULP3 1-120 |
| 246182 | pcDNA 3.3 N-MYC TULP3 1-100 | Used for transfection of cells for expression N-MYC TULP3 1-100 |
| 246183 | pcDNA 3.3 N-MYC TULP3 1-80 | Used for transfection of cells for expression N-MYC TULP3 1-80 |
| 246184 | pcDNA 3.3 N-MYC TULP3 1-60 | Used for transfection of cells for expression N-MYC TULP3 1-60 |
| 246185 | pcDNA 3.3 N-MYC TULP3 1-40 | Used for transfection of cells for expression N-MYC TULP3 1-40 |
| 246187 | pcDNA 3.3 N-MYC TULP3 delta 1-40 | Used for transfection of cells for expression N-MYC TULP3 delta 1-40 |
| 246188 | pcDNA 3.3 N-MYC TULP3 delta 1-60 | Used for transfection of cells for expression N-MYC TULP3 delta 1-60 |
| 246189 | pcDNA 3.3 N-HA mini-SIRT1-1# | Used for transfection of cells for expression N-HA mini-SIRT1-1# |
| 246190 | pcDNA 3.3 N-HA mini-SIRT1-2# | Used for transfection of cells for expression N-HA mini-SIRT1-2# |
| 246192 | pcDNA 3.3 N-HA SIRT1 1-516 | Used for transfection of cells for expression N-HA SIRT1 1-516 |
| 246193 | pcDNA 3.3 N-HA SIRT1 241-516 | Used for transfection of cells for expression N-HA SIRT1 241-516 |
| 246194 | pcDNA 3.3 N-HA SIRT1 241-747 | Used for transfection of cells for expression N-HA SIRT1 241-747 |
| 246196 | pcDNA 3.3 N-HA SIRT2 H187Y | Used for transfection of cells for expression N-HA SIRT2 DN form |
| 246197 | pcDNA 3.3 N-HA SIRT3 H248Y | Used for transfection of cells for expression N-HA SIRT3 DN form |
| 246199 | pcDNA 3.3 N-HA SIRT5 H158Y | Used for transfection of cells for expression N-HA SIRT5 DN form |
| 246201 | pcDNA 3.3 N-HA SIRT7 H187Y | Used for transfection of cells for expression N-HA SIRT7 DN form |