Hyperactive STAT5 hijacks T cell receptor signaling and drives immature T cell acute lymphoblastic leukemia.

Suske T, Sorger H, Manhart G, Ruge F, Prutsch N, Zimmerman MW, Eder T, Abdallah DI, Maurer B, Wagner C, Schonefeldt S, Spirk K, Pichler A, Pemovska T, Schweicker C, Poloske D, Hubanic E, Jungherz D, Muller TA, Aung MMK, Orlova A, Pham HTT, Zimmel K, Krausgruber T, Bock C, Muller M, Dahlhoff M, Boersma A, Rulicke T, Fleck R, de Araujo ED, Gunning PT, Aittokallio T, Mustjoki S, Sanda T, Hartmann S, Grebien F, Hoermann G, Haferlach T, Staber PB, Neubauer HA, Look AT, Herling M, Moriggl R
J Clin Invest. 2024 Apr 15;134(8):e168536. doi: 10.1172/JCI168536. PubMed Article

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