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The thymocyte-specific RNA-binding protein Arpp21 provides TCR repertoire diversity by binding to the 3'-UTR and promoting Rag1 mRNA expression.

Xu M, Ito-Kureha T, Kang HS, Chernev A, Raj T, Hoefig KP, Hohn C, Giesert F, Wang Y, Pan W, Zietara N, Straub T, Feederle R, Daniel C, Adler B, Konig J, Feske S, Tsokos GC, Wurst W, Urlaub H, Sattler M, Kisielow J, Wulczyn FG, Lyszkiewicz M, Heissmeyer V
Nat Commun. 2024 Mar 11;15(1):2194. doi: 10.1038/s41467-024-46371-z. (Link opens in a new window) PubMed (Link opens in a new window) Article

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