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Acetyl-CoA production by Mediator-bound 2-ketoacid dehydrogenases boosts de novo histone acetylation and is regulated by nitric oxide.

Russo M, Gualdrini F, Vallelonga V, Prosperini E, Noberini R, Pedretti S, Borriero C, Di Chiaro P, Polletti S, Imperato G, Marenda M, Ghirardi C, Bedin F, Cuomo A, Rodighiero S, Bonaldi T, Mitro N, Ghisletti S, Natoli G
Mol Cell. 2024 Mar 7;84(5):967-980.e10. doi: 10.1016/j.molcel.2023.12.033. Epub 2024 Jan 18. (Link opens in a new window) PubMed (Link opens in a new window) Article

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