Intracellular BAPTA directly inhibits PFKFB3, thereby impeding mTORC1-driven Mcl-1 translation and killing MCL-1-addicted cancer cells.
Sneyers F, Kerkhofs M, Speelman-Rooms F, Welkenhuyzen K, La Rovere R, Shemy A, Voet A, Eelen G, Dewerchin M, Tait SWG, Ghesquiere B, Bootman MD, Bultynck G
Cell Death Dis. 2023 Sep 8;14(9):600. doi: 10.1038/s41419-023-06120-4.
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