TIGIT can inhibit T cell activation via ligation-induced nanoclusters, independent of CD226 co-stimulation.
Worboys JD, Vowell KN, Hare RK, Ambrose AR, Bertuzzi M, Conner MA, Patel FP, Zammit WH, Gali-Moya J, Hazime KS, Jones KL, Rey C, Jonjic S, Rovis TL, Tannahill GM, Cruz De Matos GDS, Waight JD, Davis DM
Nat Commun. 2023 Aug 18;14(1):5016. doi: 10.1038/s41467-023-40755-3.
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