Mechanical activation of lung epithelial cells through the ion channel Piezo1 activates the metalloproteinases ADAM10 and ADAM17 and promotes growth factor and adhesion molecule release.

Grannemann C, Pabst A, Honert A, Schieren J, Martin C, Hank S, Boll S, Blasius K, Dusterhoft S, Jahr H, Merkel R, Leube R, Babendreyer A, Ludwig A
Biomater Adv. 2023 Sep;152:213516. doi: 10.1016/j.bioadv.2023.213516. Epub 2023 Jun 12. PubMed Article

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