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The IgG4 hinge with CD28 transmembrane domain improves V(H)H-based CAR T cells targeting a membrane-distal epitope of GPC1 in pancreatic cancer.

Li N, Quan A, Li D, Pan J, Ren H, Hoeltzel G, de Val N, Ashworth D, Ni W, Zhou J, Mackay S, Hewitt SM, Cachau R, Ho M
Nat Commun. 2023 Apr 8;14(1):1986. doi: 10.1038/s41467-023-37616-4. (Link opens in a new window) PubMed (Link opens in a new window) Article

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