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Abrogation of stemness in osteosarcoma by the mithramycin analog EC-8042 is mediated by its ability to inhibit NOTCH-1 signaling.

Estupinan O, Rey V, Tornin J, Murillo D, Gallego B, Huergo C, Blanco-Lorenzo V, Victoria Gonzalez M, Rodriguez A, Moris F, Gonzalez J, Ayllon V, Ramos-Mejia V, Bigas A, Rodriguez R
Biomed Pharmacother. 2023 Jun;162:114627. doi: 10.1016/j.biopha.2023.114627. Epub 2023 Apr 3. (Link opens in a new window) PubMed (Link opens in a new window) Article

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