Lymphoma cells lacking pro-apoptotic BAX are highly resistant to BH3-mimetics targeting pro-survival MCL-1 but retain sensitivity to conventional DNA-damaging drugs.
Diepstraten ST, Young S, La Marca JE, Wang Z, Kluck RM, Strasser A, Kelly GL
Cell Death Differ. 2023 Apr;30(4):1005-1017. doi: 10.1038/s41418-023-01117-0. Epub 2023 Feb 8.
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