A general chemical principle for creating closure-stabilizing integrin inhibitors.
Lin FY, Li J, Xie Y, Zhu J, Huong Nguyen TT, Zhang Y, Zhu J, Springer TA
Cell. 2022 Sep 15;185(19):3533-3550.e27. doi: 10.1016/j.cell.2022.08.008.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 189796 | pD2529-CAG-aIIb | Expression of full length human integrin aIIb |
| 189797 | pD2529-CAG-b3 | Expression of full length human integrin beta 3 |
| 189798 | pD2529-CAG-b3 N305T | Expression of full length human integrin beta 3 with N305T |
| 194008 | pSpCas9n(BB)-2A-puro-aV guide A | For CRISPR knockout of integrin alphaV |
| 194009 | pSpCas9n(BB)-2A-puro-aV guide B | For CRISPR knockout of integrin alphaV |
| 194010 | pSpCas9n(BB)-2A-puro-a5 guide A | For CRISPR knockout of integrin alpha5 |
| 194011 | pSpCas9n(BB)-2A-puro-a5 guide B | For CRISPR knockout of integrin alpha5 |