Allosteric activation of CRISPR-Cas12a requires the concerted movement of the bridge helix and helix 1 of the RuvC II domain.
Worle E, Newman A, D'Silva J, Burgio G, Grohmann D
Nucleic Acids Res. 2022 Sep 23;50(17):10153-10168. doi: 10.1093/nar/gkac767.
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