DOT1L activity in leukemia cells requires interaction with ubiquitylated H2B that promotes productive nucleosome binding.

Spangler CJ, Yadav SP, Li D, Geil CN, Smith CB, Wang GG, Lee TH, McGinty RK
Cell Rep. 2022 Feb 15;38(7):110369. doi: 10.1016/j.celrep.2022.110369. PubMed Article

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