Sarm1 activation produces cADPR to increase intra-axonal Ca++ and promote axon degeneration in PIPN.
Li Y, Pazyra-Murphy MF, Avizonis D, de Sa Tavares Russo M, Tang S, Chen CY, Hsueh YP, Bergholz JS, Jiang T, Zhao JJ, Zhu J, Ko KW, Milbrandt J, DiAntonio A, Segal RA
J Cell Biol. 2022 Feb 7;221(2):e202106080. doi: 10.1083/jcb.202106080. Epub 2021 Dec 22.
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