PARylation prevents the proteasomal degradation of topoisomerase I DNA-protein crosslinks and induces their deubiquitylation.

Sun Y, Chen J, Huang SN, Su YP, Wang W, Agama K, Saha S, Jenkins LM, Pascal JM, Pommier Y
Nat Commun. 2021 Aug 18;12(1):5010. doi: 10.1038/s41467-021-25252-9. PubMed Article

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