Decoupling the bridge helix of Cas12a results in a reduced trimming activity, increased mismatch sensitivity and impaired conformational transitions.

Worle E, Jakob L, Schmidbauer A, Zinner G, Grohmann D
Nucleic Acids Res. 2021 May 21;49(9):5278-5293. doi: 10.1093/nar/gkab286. PubMed Article

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