ISG15-dependent activation of the sensor MDA5 is antagonized by the SARS-CoV-2 papain-like protease to evade host innate immunity.

Liu G, Lee JH, Parker ZM, Acharya D, Chiang JJ, van Gent M, Riedl W, Davis-Gardner ME, Wies E, Chiang C, Gack MU
Nat Microbiol. 2021 Apr;6(4):467-478. doi: 10.1038/s41564-021-00884-1. Epub 2021 Mar 16. PubMed Article

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