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Loss of TGFbeta signaling increases alternative end-joining DNA repair that sensitizes to genotoxic therapies across cancer types.

Liu Q, Palomero L, Moore J, Guix I, Espin R, Aytes A, Mao JH, Paulovich AG, Whiteaker JR, Ivey RG, Iliakis G, Luo D, Chalmers AJ, Murnane J, Pujana MA, Barcellos-Hoff MH
Sci Transl Med. 2021 Feb 10;13(580). pii: 13/580/eabc4465. doi: 10.1126/scitranslmed.abc4465. (Link opens in a new window) PubMed (Link opens in a new window) Article

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