In vivo base editing rescues Hutchinson-Gilford progeria syndrome in mice.
Koblan LW, Erdos MR, Wilson C, Cabral WA, Levy JM, Xiong ZM, Tavarez UL, Davison LM, Gete YG, Mao X, Newby GA, Doherty SP, Narisu N, Sheng Q, Krilow C, Lin CY, Gordon LB, Cao K, Collins FS, Brown JD, Liu DR
Nature. 2021 Jan;589(7843):608-614. doi: 10.1038/s41586-020-03086-7. Epub 2021 Jan 6.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 154429 | hu6 HGPS sgRNA expression and ABE7.10max VRQR lentiviral plasmid | hu6 HGPS sgRNA expression and ABE7.10max VRQR lentiviral plasmid |
| 154430 | hu6 HGPS sgRNA expression and ABE7.10max VRQR C terminal AAV vector | hu6 HGPS sgRNA expression and ABE7.10max VRQR C terminal AAV vector |