Mouse models for V103I and I251L gain of function variants of the human MC4R display decreased adiposity but are not protected against a hypercaloric diet.

Rojo D, McCarthy C, Raingo J, Rubinstein M
Mol Metab. 2020 Dec;42:101077. doi: 10.1016/j.molmet.2020.101077. Epub 2020 Sep 9. PubMed Article

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