Epistane, an anabolic steroid used for recreational purposes, causes cholestasis with elevated levels of cholic acid conjugates, by upregulating bile acid synthesis (CYP8B1) and cross-talking with nuclear receptors in human hepatocytes.

Petrov PD, Fernandez-Murga L, Conde I, Martinez-Sena T, Guzman C, Castell JV, Jover R
Arch Toxicol. 2020 Jan 1. pii: 10.1007/s00204-019-02643-y. doi: 10.1007/s00204-019-02643-y. PubMed Article

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