Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression.
Lama L, Adura C, Xie W, Tomita D, Kamei T, Kuryavyi V, Gogakos T, Steinberg JI, Miller M, Ramos-Espiritu L, Asano Y, Hashizume S, Aida J, Imaeda T, Okamoto R, Jennings AJ, Michino M, Kuroita T, Stamford A, Gao P, Meinke P, Glickman JF, Patel DJ, Tuschl T
Nat Commun. 2019 May 21;10(1):2261. doi: 10.1038/s41467-019-08620-4.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 127161 | pRSFDuet-sumo-h-cGAS | expression of human cGAS protein |
| 127162 | pRSFDuet-sumo-h-cGASCD(K427E/K428E) | expression of truncated human cGAS protein |