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AKT2 phosphorylation of hexokinase 2 at T473 promotes tumorigenesis and metastasis in colon cancer cells via NF-kappaB, HIF1alpha, MMP2, and MMP9 upregulation.

Li H, Lu S, Chen Y, Zheng L, Chen L, Ding H, Ding J, Lou D, Liu F, Zheng B
Cell Signal. 2019 Jun;58:99-110. doi: 10.1016/j.cellsig.2019.03.011. Epub 2019 Mar 12. (Link opens in a new window) PubMed (Link opens in a new window) Article

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