CRISPR-mediated activation of a promoter or enhancer rescues obesity caused by haploinsufficiency.

Matharu N, Rattanasopha S, Tamura S, Maliskova L, Wang Y, Bernard A, Hardin A, Eckalbar WL, Vaisse C, Ahituv N
Science. 2018 Dec 13. pii: science.aau0629. doi: 10.1126/science.aau0629. PubMed Article

Plasmids from Article

ID	Plasmid	Purpose
115790	pCMV-sadCas9-VP64	An AAV vector expressing S. aureus dCas9 fused to VP64.
115794	pCMV-SpdCas9-VP64	Expresses SpdCas9-Vp64 fusion protein when packaged into AAV
217015	pAAV-U6-sasgRNACMV- mCherry-WPREpA	S. aureus sgRNAs backbone along with mCherry expression