Mutational processes shape the landscape of TP53 mutations in human cancer.
Giacomelli AO, Yang X, Lintner RE, McFarland JM, Duby M, Kim J, Howard TP, Takeda DY, Ly SH, Kim E, Gannon HS, Hurhula B, Sharpe T, Goodale A, Fritchman B, Steelman S, Vazquez F, Tsherniak A, Aguirre AJ, Doench JG, Piccioni F, Roberts CWM, Meyerson M, Getz G, Johannessen CM, Root DE, Hahn WC
Nat Genet. 2018 Oct;50(10):1381-1387. doi: 10.1038/s41588-018-0204-y. PubMed Article
Giacomelli AO, Yang X, Lintner RE, McFarland JM, Duby M, Kim J, Howard TP, Takeda DY, Ly SH, Kim E, Gannon HS, Hurhula B, Sharpe T, Goodale A, Fritchman B, Steelman S, Vazquez F, Tsherniak A, Aguirre AJ, Doench JG, Piccioni F, Roberts CWM, Meyerson M, Getz G, Johannessen CM, Root DE, Hahn WC
Nat Genet. 2018 Oct;50(10):1381-1387. doi: 10.1038/s41588-018-0204-y. PubMed Article
Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 113569 | TP53 MITE Library | Pooled lentiviral plasmid library containing ~8,000 single amino acid substitution and nonsense mutant variants of p53 |
| 118014 | pLX313-TP53-WT | Constitutive expression of wild-type human Tumor Protein p53 (TP53) |
| 118015 | pLX313-TP53-P278A | Constitutive expression of mutant human Tumor Protein p53 (TP53) |
| 118016 | pLX313-Renilla luciferase | Constitutive expression of Renilla luciferase |
| 118017 | pLX313-Firefly luciferase | Constitutive expression of Firefly luciferase |
| 118018 | pLX311-Cas9 | Constitutive expression of Cas9 |
| 118019 | pXPR003-sgTP53-1 | Constitutive expression of sgRNA targeting human TP53 |
| 118020 | pXPR003-sgTP53-2 | Constitutive expression of sgRNA targeting human TP53 |
| 118021 | pXPR003-sgTP53-3 | Constitutive expression of sgRNA targeting human TP53 |
| 118022 | pXPR003-sgTP53-4 | Constitutive expression of sgRNA targeting human TP53 |
| 118023 | pXPR003-sgTP53-5 | Constitutive expression of sgRNA targeting human TP53 |