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Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR.

Walton ZE, Patel CH, Brooks RC, Yu Y, Ibrahim-Hashim A, Riddle M, Porcu A, Jiang T, Ecker BL, Tameire F, Koumenis C, Weeraratna AT, Welsh DK, Gillies R, Alwine JC, Zhang L, Powell JD, Dang CV
Cell. 2018 Jun 28;174(1):72-87.e32. doi: 10.1016/j.cell.2018.05.009. Epub 2018 May 31. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
128095pGL4.22-PGK1-HRE::dLUCHypoxia response element real-time luciferase reporter
128096pGL4.22-VEGF-HRE::dLUCHypoxia response element real-time luciferase reporter
128097PX458-sgEIF4EBP1CRISPR gRNA against human EIF4EBP1 (4EBP1) with Cas9 from S. pyogenes and 2A-EGFP
128098PX458-sgTSC2CRISPR gRNA against human TSC2 with Cas9 from S. pyogenes and 2A-EGFP
128099pcDNA3.1+ Flag-RAP2AExpresses RAP2A in mammalian cells in a G418-selectable plasmid
128101pcDNA3.1+ Flag-RAGB99LExpresses constitutively GTP-bound RAGB in mammalian cells in a G418-selectable plasmid

Antibodies from Article