A single N-terminal phosphomimic disrupts TDP-43 polymerization, phase separation, and RNA splicing.
Wang A, Conicella AE, Schmidt HB, Martin EW, Rhoads SN, Reeb AN, Nourse A, Ramirez Montero D, Ryan VH, Rohatgi R, Shewmaker F, Naik MT, Mittag T, Ayala YM, Fawzi NL
EMBO J. 2018 Mar 1;37(5). pii: embj.201797452. doi: 10.15252/embj.201797452. Epub 2018 Feb 9.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 104478 | TDP-43_NTD1-80_Y4R | bacterial expression of TDP-43 NTD Y4R |
| 104479 | TDP-43_NTD1-80_E17R | bacterial expression of TDP-43 NTD E17R |
| 104480 | pJ4M/TDP-43 | bacterial expression of TDP-43 |
| 104481 | pJ4M/TDP-43 S48E | bacterial expression of TDP-43 S48E |