Most mutations that cause spinocerebellar ataxia autosomal recessive type 16 (SCAR16) destabilize the protein quality-control E3 ligase CHIP.

Kanack AJ, Newsom OJ, Scaglione KM
J Biol Chem. 2018 Feb 23;293(8):2735-2743. doi: 10.1074/jbc.RA117.000477. Epub 2018 Jan 9. PubMed Article

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